| Project/Area Number |
15K15094
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Tokyo Metropolitan Institute of Medical Science |
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Principal Investigator |
HIRABAYASHI Tetsuya 公益財団法人東京都医学総合研究所, 生体分子先端研究分野, 主席研究員 (90345025)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | リン脂質代謝 / ホスファチジルコリン / コリン / メチオニン / メチル化 / メタボロミクス / 肝臓 / 神経変性 / グリセロホスホコリン |
|---|
| Outline of Final Research Achievements |
We have found that the iPLA2gamma/iPLA2theta/GED axis functions as an intrinsic choline production pathway that mobilizes free choline from the membrane phospholipids in the liver and shown that this pathway is involved in the methionine regeneration and liver function. Moreover, iPLA2theta deficiency causes profound neuronal degeneration in the brain and browning of white adipose tissues, indicating that the novel choline production pathway that we have identified has also a crucial role in neuronal survival and energy metabolism.
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