To reveal regulatory mechanisms and strategy for regulation of susceptibility to immune-related diseases and infectious diseases by IkBL molecule

• Project/Area Number: 15K15095
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Human genetics
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: kimura Akinori 東京医科歯科大学, 難治疾患研究所, 教授 (60161551)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 遺伝子 / ウイルス / 感染症 / 免疫学 / 生体分子

Outline of Final Research Achievements

Aim of this study was to investigate the functional involvement of HLA-linked IkBL gene (NFKBIL1) in the regulation of susceptibility to infectious disease and immune-related diseases, especially focusing on HIV infection. By analyzing polymorphisms in IkBL promoter region, it was found that susceptibility to HIV infection as associated with low expression allele of IkBL. By using T cell line and epithelial cell line overexpressing IkBL, it was suggested that IkBL inhibited replication of HIV. In addition, it was observed that spicing of many genes was regulated by IkBL. Furthermore, a novel HIV infection-related gene, of which splicing was regulated by IkBL, was identified to be involved in the regulation of HIV infection.

Research Products

• [Int'l Joint Research] All India Institute of Medical Sciences(インド)
• [Int'l Joint Research] All India Institute of Mecical Sciences(インド)
• [Journal Article] APOBEC3H polymorphisms and susceptibility to HIV-1 infection in an Indian population (2016)
  • Author(s): Naruse TK, Sakurai D, Ohtani H, Sharma G, Sharma SK, Vajpayee M, Narinder KM, Kaur G, Kimura A
  • Journal Title: J Hum Genet Volume: 61 Issue: 3 Pages: 263-265
  • DOI: 10.1038/jhg.2015.136
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] APOBEC3H polymorphisms associated with susceptibility to HIV-1 infection and AIDS progression in Japanese. (2015)
  • Author(s): Sakurai D, Iwatani Y, Ohtani H, Naruse TK, Terunuma H, Sugiura W, Kimura A.
  • Journal Title: Immunogenetics Volume: 67 Issue: 4 Pages: 253-257
  • DOI: 10.1007/s00251-015-0829-2
  • Peer Reviewed
• [Presentation] IkBL regulates susceptibility to HIV-1 infection (2016)
  • Author(s): Akinori Kimura, Taeko K. Naruse, Daisuke Sakurai, Jianbo An, Hiroshi Terunuma, Emi E. Nakayama, Tatsuo Shioda, Gaurav Sharma, Narinder Mehra, Gurvinder Kaur.
  • Organizer: The 13th International Congress of Human Genetics
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2016-04-04
  • Int'l Joint Research
• [Presentation] APOBEC3H polymorphisms are associated with susceptibility to HIV-1 infection and development of AIDS in Asian populations (2016)
  • Author(s): Taeko K. Naruse, Daisuke Sakurai, Hitoshi Ohtani, Hiroshi Terunuma, Yasumasa Iwatani,Wataru Sugiura, Gaurav Sharma, Narinder Mehra, Gurvinder Kaur, Akinori Kimura
  • Organizer: The 13th International Congress of Human Genetics
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2016-04-04
  • Int'l Joint Research
• [Presentation] IkBL によるHIV-1 感染感受性の制御 (2015)
  • Author(s): 成瀬妙子、中山英美、安健博、Gaurav Sharma、Narinder Mehra、塩田達雄、Gurvinder Kaur、木村彰方
  • Organizer: 日本人類遺伝学会第60 回大会
  • Place of Presentation: 京王プラザホテル（東京）
  • Year and Date: 2015-10-15
• [Presentation] IkBL はHIV-1 感染感受性を制御する (2015)
  • Author(s): 成瀬妙子、櫻井大祐、安健博、中山英美、塩田達雄、Gaurav Sharma、Narinder Mehra、Gurvinder Kaur、 木村彰方
  • Organizer: 第２４回日本組織適合性学会大会
  • Place of Presentation: ホテルレイクビュー水戸（水戸）
  • Year and Date: 2015-09-10