Creation of human novel totipotent stem cells (Superstem cell) and construction of pathological characteristics analysis database

• Project/Area Number: 15K15103
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Human pathology
• Research Institution: National Center for Child Health and Development
• Principal Investigator: NAKAZAWA ATSUKO 国立研究開発法人国立成育医療研究センター, 病理診断部, (非)研究員 (90227736)
• Co-Investigator(Kenkyū-buntansha): 梅澤 明弘 国立研究開発法人国立成育医療研究センター, 再生医療センター, 副所長/再生医療センター長 (70213486)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
• Keywords: 移植病理 / 奇形腫（テラトーマ） / 再生医療 / 特性解析 / テラトーマ

Outline of Final Research Achievements

In this study evaluating teratoma formation, it was possible to show cell safety and effectiveness by evaluation of biomarker biomarkers. In addition, this study was able to transmit the superstemcest pathologic histology test system from Japan to the world in a form such as correlation between in vivo phenotype and various genotypes. This research is a pioneer of suitable new pluripotent stem cell research in the future and was the world leading research for clinical application of regenerative medicine.