Development of early clinical reagents for Alzheimer's disease using citrullinated proteins as index
| Project/Area Number |
15K15104
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Human pathology
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| Research Institution | Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology |
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Principal Investigator |
Ishigami Akihito 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究部長 (50270658)
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| Project Period (FY) |
2015-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 神経変性疾患 / 脳神経疾患 |
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| Outline of Final Research Achievements |
We have identified for the first time citrullinated Alzheimer's disease-related proteins in the brains of Alzheimer's disease patients. We also succeeded in developing clinical laboratory diagnostic reagents that quantify it’s citrullinated proteins. It has potential to be useful as a clinical diagnostic agent for quantifying citrullinated Alzheimer's disease-related proteins. In the future, we will verify the usefulness as an early clinical diagnostic agent for Alzheimer's disease.
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| Academic Significance and Societal Importance of the Research Achievements |
アルツハイマー病の早期臨床検査試薬は未だ開発されていない。本研究成果は、アルツハイマー病を診断する臨床診断薬に繋がる可能性がある。
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Report
(5 results)
Research Products
(27 results)
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[Journal Article] Carbamylated albumin is one of the target antigens of anti-carbamylated protein antibodies.2017
Author(s)
Nakabo S, Hashimoto M, Ito S, Furu M, Ito H, Fujii T, Yoshifuji H, Imura Y, Nakashima R, Murakami K, Kuramoto N, Tanaka M, Satoh J, Ishigami A, Morita S, Mimori T, Ohmura K.
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Journal Title
Rheumatology (Oxford)
Volume: in press
Issue: 7
Pages: 1217-1226
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Prevalence of soluble peptidylarginine deiminase 4 (PAD4) and anti-PAD4 antibodies in autoimmune diseases.2016
Author(s)
Umeda N, Matsumoto I, Kawaguchi H, Kurashima Y, Kondo Y, Tsuboi H, Ogishima H, Suzuki T, Kagami Y, Sakyu T, Ishigami A, Maruyama N, Sumida T.
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Journal Title
Clin Rheumatol.
Volume: 35
Issue: 5
Pages: 1181-1188
DOI
Related Report
Peer Reviewed
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[Journal Article] Mass spectrometric identification of citrullination sites and immunohistochemical detection of citrullinated glial fibrillary acidic protein in Alzheimer's disease brains.2015
Author(s)
Ishigami, A., Masutomi, H., Handa, S., Nakamura, M., Nakaya, S., Uchida, Y., Saito, Y., Murayama, S., Jang, B., Jeon, Y.C., Choi, E.K., Kim, Y.S., Kasahara, Y., Maruyama, N., Toda, T.
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Journal Title
J. Neurosci. Res.
Volume: 93
Issue: 11
Pages: 1664-1674
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Presentation] Detection of citrullinated proteins in the postmortem brain from wild-type and PAD2-knockout mice using newly developed anti-modified citrulline monoclonal antibodies.2015
Author(s)
Kagami, Y. Masutomi, H., Choi, E.K., Kim, Y.S., Maruyama, N., Ishigami, A.
Organizer
The 10th IAGG Asia/Oceania Regional Congress (IAGG 2015)
Place of Presentation
The International Convention and Exhibition Centre, Chiang Mai, Thailand
Year and Date
2015-10-19
Related Report
Int'l Joint Research
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