| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
The involvement of autophagy in various diseases is being clarified, and autophagy has attracted attention from the viewpoint of disease control. In this study, we focusing on inflammatory bowel disease (IBD) which has been increasing in recent years, the possibility of autophagy disease control was examined. We confirmed that autophagy is important for intestinal stem cell homeostasis and intestinal epithelium regeneration. Furthermore, inflammation exacerbations of intestinal epithelium lacking autophagy were confirmed in mouse enteritis model using 5-FU. This study revealed that autophagy is important for regeneration of the intestinal epithelium, suggesting the usefulness of autophagy in the clarification and control of IBD pathogenesis.
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