| Project/Area Number |
15K15123
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Parasitology (including sanitary zoology)
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| Research Institution | Kagawa University |
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Principal Investigator |
ARAI Meiji 香川大学, 医学部, 准教授 (30294432)
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| Co-Investigator(Kenkyū-buntansha) |
平井 誠 順天堂大学, 医学部, 准教授 (50326849)
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| Co-Investigator(Renkei-kenkyūsha) |
TOKUDA Masaaki 香川大学, 医学部, 教授 (10163974)
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| Research Collaborator |
TERANAKA Masato 香川大学, 医学部, 教務職員 (20294770)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | マラリア / ハマダラカ / 伝播阻止 / 希少糖 / D-アロース / ヘキソース・トランスポーター / Ｄ－アロース / マラリア伝播阻止 |
|---|
| Outline of Final Research Achievements |
We demonstrated that D-allose, a kind of rare sugars, has strong transmission-blocking effect against rodent malaria parasite, Plasmodium berghei, in the vector mosquito Anopheles stephensi. Furthermore, rare sugar-containing syrup widely available at stores has been shown to possess transmission-blocking effect which is comparable in efficacy to D-allose. These results will have a striking positive impact for developing a new transmission-blocking method using rare sugars in malaria-endemic countries.
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