| Project/Area Number |
15K15130
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Bacteriology (including mycology)
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
野澤 孝志 京都大学, 医学研究科, 助教 (10598858)
相川 知宏 京都大学, 医学研究科, 助教 (70725499)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | A群レンサ球菌 / オートファジー / イメージング / Rabタンパク質 / ゼノファジー / 膜形成 |
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| Outline of Final Research Achievements |
In this study, we selected a probe for visualization of infection step using group A Streptococcus as a model, and introduced a multidimensional fluorescence imaging system. We found that Rab 17, Rab 30 and Rab35 could colocalized to bacteria-induced autophagosome specifically. In particular, it was revealed that Rab 35 was involved in the formation of bacteria-induced autophagosomes by direct binding to NDP 52, which is an adapter protein. These results indicate that some specific Rab proteins are important for bacteria-induced autophagy.
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