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Identification of receptor for cell-to-cell infection of HSV

Research Project

Project/Area Number 15K15138
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Virology
Research InstitutionThe University of Tokyo

Principal Investigator

Arii Jun  東京大学, 医科学研究所, 助教 (30704928)

Co-Investigator(Renkei-kenkyūsha) KAWAGUCHI Yasushi  東京大学, 医科学研究所, 教授 (60292984)
Research Collaborator KATO Akihisa  東京大学, 医科学研究所, 助教
KOYANAGI Naoto  東京大学, 医科学研究所, 特任研究員
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
KeywordsHSV / glycoprotein / 膜タンパク質 / 細胞間感染 / ウイルス / レセプター / 細胞間伝播 / ヘルペスウイルス / 糖タンパク質
Outline of Final Research Achievements

We investigated the mechanism of HSV cell-to-cell infection and identified new cellular factor which promotes cell-to-cell infection of HSV. This protein was interacted with viral gE, which is kwon to be important for cell-to-cell infection. Moreover, this protein was required for gE-dependent cell-to-cell infection. Thus, understanding of molecular mechanism of cell-to-cell infection of HSV may indicate new prophylactic and therapeutic approaches for the development of antiherpetic drugs.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (82 results)

All 2018 2017 2016 2015 Other

All Journal Article (16 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 16 results,  Open Access: 15 results,  Acknowledgement Compliant: 10 results) Presentation (62 results) (of which Int'l Joint Research: 24 results,  Invited: 1 results) Book (1 results) Remarks (3 results)

  • [Journal Article] Herpes Simplex Virus 1 VP22 Inhibits AIM2-Dependent Inflammasome Activation to Enable Efficient Viral Replication.2018

    • Author(s)
      Maruzuru Y, Ichinohe T, Sato R, Miyake K, Okano T, Suzuki T, Koshiba T, Koyanagi N, Tsuda S, Watanabe M, Arii J, Kato A, Kawaguchi Y.
    • Journal Title

      Cell Host Microbe.

      Volume: 23 Issue: 2 Pages: 254-265

    • DOI

      10.1016/j.chom.2017.12.014

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Herpes simplex virus-1 evasion of CD8+ T cell accumulation contributes to viral encephalitis.2017

    • Author(s)
      Koyanagi N, Imai T, Shindo K, Sato A, Fujii W, Ichinohe T, Takemura N, Kakuta S, Uematsu S, Kiyono H, Maruzuru Y, Arii J, Kato A, Kawaguchi Y.
    • Journal Title

      J Clin Invest.

      Volume: 127 Issue: 10 Pages: 3784-3795

    • DOI

      10.1172/jci92931

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Herpes Simplex Virus 1 Small Capsomere-Interacting Protein VP26 Regulates Nucleocapsid Maturation.2017

    • Author(s)
      Kobayashi R, Kato A, Sagara H, Watanabe M, Maruzuru Y, Koyanagi N, Arii J, Kawaguchi Y.
    • Journal Title

      J Virol.

      Volume: 91 Issue: 18

    • DOI

      10.1128/jvi.01068-17

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Herpes Simplex Virus 1 UL34 Protein Regulates the Global Architecture of the Endoplasmic Reticulum in Infected Cells.2017

    • Author(s)
      F. Maeda, J. Arii, Y. Hirohata, Y. Maruzuru, N. Koyanagi, A. Kato and Y. Kawaguchi.
    • Journal Title

      J. Virol.

      Volume: 印刷中 Issue: 12

    • DOI

      10.1128/jvi.00271-17

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Roles of Us8A and its phosphorylation mediated by Us3 in herpes simplex virus 1 pathogenesis.2016

    • Author(s)
      A. Kato, T. Ando, S. Oda, M. Watanabe, N. Koyanagi, J. Arii and Y. Kawaguchi.
    • Journal Title

      Journal of Virology

      Volume: 印刷中 Issue: 12 Pages: 5622-5635

    • DOI

      10.1128/jvi.00446-16

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] p53 is a Host Cell Regulator during Herpes Simplex Encephalitis.2016

    • Author(s)
      Maruzuru Y, Koyanagi N, Takemura N, Uematsu S, Matsubara D, Suzuki Y, Arii J, Kato A, Kawaguchi Y.
    • Journal Title

      J Virol.

      Volume: 90(15) Issue: 15 Pages: 6738-6745

    • DOI

      10.1128/jvi.00846-16

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Interaction between Herpes Simplex Virus 1 Tegument Proteins UL51 and UL14 and Its Role in Virion Morphogenesis.2016

    • Author(s)
      S. Oda, J. Arii, N. Koyanagi, A. Kato, and Y. Kawaguchi.
    • Journal Title

      Journal of Virology

      Volume: 90 Issue: 19 Pages: 8754-8767

    • DOI

      10.1128/jvi.01258-16

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Multiple Roles of the Cytoplasmic Domain of Herpes Simplex Virus 1 Envelope Glycoprotein D in Infected Cells.2016

    • Author(s)
      Arii J, Shindo K, Koyanagi N, Kato A, Kawaguchi Y.
    • Journal Title

      J Virol.

      Volume: 90 Pages: 10170-10181

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Roles of Us8A and its phosphorylation mediated by Us3 in herpes simplex virus 1 pathogenesis.2016

    • Author(s)
      Kato A, Tomoko A, Oda S, Watanabe M, Koyanagi N, Arii J, Kawaguchi Y.
    • Journal Title

      J Virol.

      Volume: JVI Pages: 00446-16

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Ubiquitin-Specific Protease 9X in Host Cells Interacts with Herpes Simplex Virus 1 ICP0.2016

    • Author(s)
      Y. Sato, A. Kato, J. Arii, N. Koyanagi, H. Kozuka-Hata, M. Oyama and Y. Kawaguchi.
    • Journal Title

      The Journal of Veterinary Medical Science

      Volume: 2016 Issue: 6 Pages: 405-10

    • DOI

      10.1128/jvi.03043-15

    • NAID

      130005140885

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Ubiquitin-specific protease 9X in host cells interacts with herpes simplex virus 1 ICP02016

    • Author(s)
      Sato Y, Kato A, Arii J, Koyanagi N, Kozuka-Hata H, Oyama M, Kawaguchi Y.
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 78 Issue: 3 Pages: 405-410

    • DOI

      10.1292/jvms.15-0598

    • NAID

      130005140885

    • ISSN
      0916-7250, 1347-7439
    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Characterization of a Herpes Simplex Virus 1 (HSV-1) Chimera in Which the Us3 Protein Kinase Gene Is Replaced with the HSV-2 Us3 Gene.2015

    • Author(s)
      Shindo K, Kato A, Koyanagi N, Sagara H, Arii J, Kawaguchi Y.
    • Journal Title

      J Virol.

      Volume: 90 Issue: 1 Pages: 457-473

    • DOI

      10.1128/jvi.02376-15

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Role of Host Cell p32 in Herpes Simplex Virus 1 De-Envelopment during Viral Nuclear Egress.2015

    • Author(s)
      Liu Z, Kato A, Oyama M, Kozuka-Hata H, Arii J, Kawaguchi Y.
    • Journal Title

      J Virol

      Volume: 89 Issue: 17 Pages: 8982-8998

    • DOI

      10.1128/jvi.01220-15

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Herpes simplex virus 1 recruits CD98 heavy chain and β1 integrin to the nuclear membrane for viral de-envelopment.2015

    • Author(s)
      Y. Hirohata, J. Arii, Z. Liu, K. Shindo, M. Oyama, H. Kozuka-Hata, H. Sagara, A. Kato, and Y. Kawaguchi.
    • Journal Title

      Journal of Virology

      Volume: 89 Issue: 15 Pages: 7799-812

    • DOI

      10.1128/jvi.00741-15

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The Function of the Herpes Simplex Virus 1 Small Capsid Protein VP26 is Regulated by Phosphorylation at a Specific Site.2015

    • Author(s)
      R. Kobayashi, A. Kato, S. Oda, N. Koyanagi, M. Oyama, H. Kozuka-Hata, J. Arii, and Y. Kawaguchi.
    • Journal Title

      Journal of Virology

      Volume: 89 Issue: 11 Pages: 6141-7

    • DOI

      10.1128/jvi.00547-15

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Interactome Analysis of Herpes Simplex Virus 1 Envelope Glycoprotein H.2015

    • Author(s)
      Y. Hirohata, A. Kato, M. Oyama, H. Kozuka-Hata, N. Koyanagi, J. Arii and Y. Kawaguchi.
    • Journal Title

      Microbiology and Immunology

      Volume: 印刷中 Issue: 6 Pages: 331-7

    • DOI

      10.1111/1348-0421.12255

    • NAID

      40020510068

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] 単純ヘルペスウイルス(HSV)の細胞間伝播を促進する宿主細胞膜タンパク質の同定2017

    • Author(s)
      渡邉瑞季, 有井潤, 下島昌幸, 加藤哲久, 川口寧
    • Organizer
      第14回ウイルス学キャンプ in 湯河原
    • Related Report
      2017 Annual Research Report
  • [Presentation] 単純ヘルペスウイルスと宿主細胞膜との相互作用2017

    • Author(s)
      有井 潤
    • Organizer
      第14回ウイルス学キャンプ in 湯河原
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] HSV-1 UL51 リン酸化制御機構と細胞種依存的な新規機能の解明2017

    • Author(s)
      尾田真也, 加藤哲久, 丸鶴雄平, 小栁直人, 有井潤, 川口寧
    • Organizer
      第31回ヘルペスウイルス研究会
    • Related Report
      2017 Annual Research Report
  • [Presentation] HSV-2のウイルス増殖および病原性はUL13プロテインキナーゼのリン酸化によって制御される2017

    • Author(s)
      小栁直人, 加藤哲久, 丸鶴雄平, 有井潤, 川口寧
    • Organizer
      第31回ヘルペスウイルス研究会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ESCRT-IIIは小胞媒介性核外輸送における膜切断を仲介し、核内膜の恒常性維持に寄与する2017

    • Author(s)
      有井潤, 渡邉瑞季, 前田史雄, 加藤哲久, 川口寧
    • Organizer
      第31回ヘルペスウイルス研究会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Inhibition of AIM2 inflammasome activation by an HSV-1 virion component enables efficient viral replication in vivo2017

    • Author(s)
      Yuhei Maruzuru, Takeshi Ichinohe, Naoto Koyanagi, Jun Arii, Akihisa Kato and Yasushi Kawaguchi
    • Organizer
      第31回ヘルペスウイルス研究会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 単純ヘルペスウイルス1型UL34は小胞体の形態制御を行い、ヌクレオカプシドの核出芽輸送制御因子の核膜への集積に関与する2017

    • Author(s)
      前田史雄, 廣畑吉崇, 有井潤, 加藤哲久, 川口寧
    • Organizer
      第31回ヘルペスウイルス研究会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 単純ヘルペスウイルス(HSV)の細胞間感染を促進する宿主タンパク質の同定2017

    • Author(s)
      渡邉瑞季, 有井潤, 下島昌幸, 加藤哲久, 川口寧
    • Organizer
      第31回ヘルペスウイルス研究会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ヘルペスウイルスカプシドの核外輸送は宿主機構のハイジャックによって達成される2017

    • Author(s)
      有井潤, 渡邉瑞季, 川口寧
    • Organizer
      第160回日本獣医学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 単純ヘルペスウイルスgEと相互作用して細胞間感染を促進する宿主因子の同定2017

    • Author(s)
      渡邉瑞季, 有井潤, 下島昌幸, 川口寧
    • Organizer
      第160回日本獣医学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ESCRT-III mediates vesicle-mediated nuclear export to regulate nuclear egress of HSV-1 capsids and integrity of the inner nuclear membrane2017

    • Author(s)
      Jun Arii, Mizuki Watanabe, Fumio Maeda, Yuhei Maruzuru, Naoto Koyanagi, Akihisa Kato, Yasushi Kawaguchi
    • Organizer
      第65回日本ウイルス学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Cell type-specific regulation of the nuclear egress of herpes simplex virus type1 by phosphorylation of UL51 Ser-1842017

    • Author(s)
      Shinya Oda, Akihisa Kato, Yuhei Maruzuru, Naoto Koyanagi, Jun Arii, Yasushi Kawaguchi
    • Organizer
      第65回日本ウイルス学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Evasion of AIM2-Dependent Inflamasome Activation by Herpes Simplex Virus 1 Virion Protein Enables Efficient Viral Replication In Vivo2017

    • Author(s)
      Yuhei Maruzuru, Takeshi Ichinohe, Naoto Koyanagi, Zhuoming Liu, Tomoko Ando, Jun Arii, Akihisa Kato, Yasushi Kawaguchi
    • Organizer
      第65回日本ウイルス学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] A host cell membrane protein interacts with HSV-1 gE and promotes viral cell-to-cell spread2017

    • Author(s)
      Mizuki Watanabe, Jun Arii, Masayuki Shimojima, Akihisa Kato, Yasushi Kawaguchi
    • Organizer
      第65回日本ウイルス学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Naoto Koyanagi, Akihisa Kato, Yuhei Maruzuru, Jun Arii, Yasushi Kawaguchi Function of the herpes simplex virus 2 protein kinase UL13 in vitro and in vivo is regulated by phosphorylation2017

    • Author(s)
      Naoto Koyanagi, Akihisa Kato, Yuhei Maruzuru, Jun Arii, Yasushi Kawaguchi
    • Organizer
      第65回日本ウイルス学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Molecular mechanism of HSV-1 nuclear egress2017

    • Author(s)
      Jun Arii
    • Organizer
      CAS-IMSUT Workshop on Infectious Diseases
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Inhibition of AIM2 inflammasome activation by an HSV-1 virion component enables efficient viral replication in vivo2017

    • Author(s)
      Yuhei Maruzuru, Takeshi Ichinohe, Naoto Koyanagi, Jun Arii, Akihisa Kato and Yasushi Kawaguchi
    • Organizer
      42nd Annual International Herpesvirus Workshop
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Identification of a host cell membrane protein that interacts with HSV-1 gE and promotes viral cell-to-cell spread2017

    • Author(s)
      Mizuki Watanabe, Jun Arii, Masayuki Shimojima, Naoto Koyanagi, Yuhei Maruzuru, Akihisa Kato and Yasushi Kawaguchi
    • Organizer
      42nd Annual International Herpesvirus Workshop
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Herpes simplex virus type 1 UL51 Protein Regulates Virion Morphogenesis in the Nucleus in a Cell type and Phosphorylation-Dependent Manner2017

    • Author(s)
      Shinya Oda, Akihisa Kato, Naoto Koyanagi, Yuhei Maruzuru, Jun Arii and Yasushi Kawaguchi
    • Organizer
      42nd Annual International Herpesvirus Workshop
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ESCRT-III mediates vesicle-mediated nuclear export and regulates the integrity of the inner nuclear membrane2017

    • Author(s)
      Jun Arii, Mizuki Watanabe, Fumio Maeda, Yuhei Maruzuru, Naoto Koyanagi, Akihisa Kato and Yasushi Kawaguchi
    • Organizer
      42nd Annual International Herpesvirus Workshop
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Regulation of herpes simplex virus-2 UL13 protein kinase by phosphorylation is important for viral replication, pathogenic manifestations, and virulence in vivo2017

    • Author(s)
      Naoto Koyanagi, Akihisa Kato, Yuhei Maruzuru, Jun Arii and Yasushi Kawaguchi
    • Organizer
      42nd Annual International Herpesvirus Workshop
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Herpes simplex 1 UL34 Protein Regurates the Global Architecture of the Endoplasmic Reticulum in Infected Cells2017

    • Author(s)
      Fumio Maeda, Jun Arii, Yuhei Maruzuru, Naoto Koyanagi, Akihisa Kato and Yasushi Kawaguchi
    • Organizer
      42nd Annual International Herpesvirus Workshop
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Investigation of a novel interaction between the endosomal sorting protein SNX3 and HSV-1 membrane proteins2016

    • Author(s)
      Akihisa Kato, Hayato Harima, Jun Arii, Yasushi Kawaguchi
    • Organizer
      第64回日本ウイルス学会学術集会
    • Place of Presentation
      札幌コンベンションセンター(北海道札幌市)
    • Year and Date
      2016-10-23
    • Related Report
      2016 Research-status Report
  • [Presentation] Identification of host factors that mediate HSV-1 nuclear egress2016

    • Author(s)
      Jun Arii, Fumio Maeda, Akihisa Kato, Yasushi Kawaguchi
    • Organizer
      第64回日本ウイルス学会学術集会
    • Place of Presentation
      札幌コンベンションセンター(北海道札幌市)
    • Year and Date
      2016-10-23
    • Related Report
      2016 Research-status Report
  • [Presentation] HSV-1 nucleocapsid maturation is regulated by small capsid protein VP262016

    • Author(s)
      Ryosuke Kobayashi, Akihisa Kato, Jun Arii, Yasushi Kawaguchi
    • Organizer
      第64回日本ウイルス学会学術集会
    • Place of Presentation
      札幌コンベンションセンター(北海道札幌市)
    • Year and Date
      2016-10-23
    • Related Report
      2016 Research-status Report
  • [Presentation] HSV-1 UL34 is required for proper targeting of viral and cellular regulators for viral de-envelopment at the nuclear membrane2016

    • Author(s)
      Fumio Maeda, Yoshitaka Hirohata, Jun Arii, Akihisa Kato, Yasushi Kawaguchi
    • Organizer
      第64回日本ウイルス学会学術集会
    • Place of Presentation
      札幌コンベンションセンター(北海道札幌市)
    • Year and Date
      2016-10-23
    • Related Report
      2016 Research-status Report
  • [Presentation] Enzymatic activity of HSV-1 UNG and viral pathogenesis are regulated by its phosphorylation at a specific site2016

    • Author(s)
      Hayato Harima, Akihisa Kato, Mizuki Watanabe, Jun Arii, Yasushi Kawaguchi
    • Organizer
      第64回日本ウイルス学会学術集会
    • Place of Presentation
      札幌コンベンションセンター(北海道札幌市)
    • Year and Date
      2016-10-23
    • Related Report
      2016 Research-status Report
  • [Presentation] ヘルペスウイルスnuclear egress complexは、宿主因子を介して核内膜の切断を引き起こす2016

    • Author(s)
      有井潤, 前田文雄, 加藤哲久, 川口寧
    • Organizer
      第159回日本獣医学会学術集会
    • Place of Presentation
      日本大学生物資源科学部(神奈川県藤沢市)
    • Year and Date
      2016-09-06
    • Related Report
      2016 Research-status Report
  • [Presentation] Herpes simplex virus 1 VP26 is a regulator of nucleocapsid maturation2016

    • Author(s)
      Ryosuke Kobayashi, Akihisa Kato, Jun Arii, Yasushi Kawaguchi
    • Organizer
      The 15th Awaji International Forum on Infection and Immunity
    • Place of Presentation
      淡路夢舞台国際会議場(兵庫県淡路市)
    • Year and Date
      2016-09-06
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] HSV UNG phosphorylation at a specific site regulates its enzymatic activity and viral pathogenesis2016

    • Author(s)
      Hayato Harima, Akihisa Kato, Mizuki Watanabe, Jun Arii, Yasushi Kawaguchi
    • Organizer
      第5回感染症若手フォーラム
    • Place of Presentation
      淡路夢舞台国際会議場(兵庫県淡路市)
    • Year and Date
      2016-09-04
    • Related Report
      2016 Research-status Report
  • [Presentation] 単純ヘルペスウイルス1型による小胞体の形態制御2016

    • Author(s)
      前田史雄,廣畑吉崇,有井潤,加藤哲久,川口寧
    • Organizer
      第13回ウイルス学キャンプ in 湯河原
    • Place of Presentation
      ニューウェルシティ湯河原(静岡県熱海市)
    • Year and Date
      2016-08-30
    • Related Report
      2016 Research-status Report
  • [Presentation] Roles of Us8A and its Phosphorylation Mediated by Us3 in Herpes Simplex Virus 1 Pathogenesis2016

    • Author(s)
      Akihisa Kato, Tomoko Ando, Jun Arii, Yasushi Kawaguchi
    • Organizer
      41st Annual International Herpesvirus Workshop
    • Place of Presentation
      Monona Terrace Community and Convention Center (Madison, Wisconsin, USA)
    • Year and Date
      2016-07-23
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] ESCRT-III mediates HSV-1 Nuclear Egress2016

    • Author(s)
      Jun Arii, Fumio Maeda, Akihisa Kato, Yasushi Kawaguchi
    • Organizer
      41st Annual International Herpesvirus Workshop
    • Place of Presentation
      Monona Terrace Community and Convention Center (Madison, Wisconsin, USA)
    • Year and Date
      2016-07-23
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] HSV-1 VP26 is a Regulator of Nucleocapsid Maturation2016

    • Author(s)
      Ryosuke Kobayashi, Akihisa Kato, Jun Arii, Yasushi Kawagushi
    • Organizer
      41st Annual International Herpesvirus Workshop
    • Place of Presentation
      Monona Terrace Community and Convention Center (Madison, Wisconsin, USA)
    • Year and Date
      2016-07-23
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Endosomal sorting protein SNX3とHSV膜蛋白質の相互作用に関する解析2016

    • Author(s)
      加藤哲久, 播磨勇人, 有井潤, 川口寧
    • Organizer
      第30回ヘルペスウイルス研究会
    • Place of Presentation
      セミナーハウス クロス・ウェーブ府中(東京都府中市)
    • Year and Date
      2016-06-16
    • Related Report
      2016 Research-status Report
  • [Presentation] HSV-1 nuclear egress complex は、宿主因子を介して核内膜の切断を引き起こす2016

    • Author(s)
      有井潤, 前田史雄, 加藤哲久, 川口寧
    • Organizer
      第30回ヘルペスウイルス研究会
    • Place of Presentation
      セミナーハウス クロス・ウェーブ府中(東京都府中市)
    • Year and Date
      2016-06-16
    • Related Report
      2016 Research-status Report
  • [Presentation] HSV-1 UL34による小胞媒介性核外輸送関連タンパク質の局在制御2016

    • Author(s)
      前田史雄, 廣畑吉崇, 加藤哲久, 有井潤, 川口寧
    • Organizer
      第30回ヘルペスウイルス研究会
    • Place of Presentation
      セミナーハウス クロス・ウェーブ府中(東京都府中市)
    • Year and Date
      2016-06-16
    • Related Report
      2016 Research-status Report
  • [Presentation] HSV-1 UNGリン酸化の生物学的意義2016

    • Author(s)
      播磨勇人, 加藤哲久, 渡邉瑞希, 有井潤, 川口寧
    • Organizer
      第30回ヘルペスウイルス研究会
    • Place of Presentation
      セミナーハウス クロス・ウェーブ府中(東京都府中市)
    • Year and Date
      2016-06-16
    • Related Report
      2016 Research-status Report
  • [Presentation] HSV-1キャプシドタンパク質VP26はキャプシドの成熟を制御する2016

    • Author(s)
      小林亮介, 加藤哲久, 有井潤, 川口寧
    • Organizer
      第30回ヘルペスウイルス研究会
    • Place of Presentation
      セミナーハウス クロス・ウェーブ府中(東京都府中市)
    • Year and Date
      2016-06-16
    • Related Report
      2016 Research-status Report
  • [Presentation] p53はHSV-1の神経病原性に関与する2016

    • Author(s)
      丸鶴雄平, 小栁直人, 有井潤, 加藤哲久, 川口寧
    • Organizer
      第30回ヘルペスウイルス研究会
    • Place of Presentation
      セミナーハウス クロス・ウェーブ府中(東京都府中市)
    • Year and Date
      2016-06-16
    • Related Report
      2016 Research-status Report
  • [Presentation] Jun Arii, Akihisa Kato, Yasushi Kawaguchi2015

    • Author(s)
      Membrane deformation for HSV-1 secondary envelopment is mediated by its glycoproteins.
    • Organizer
      第63回日本ウイルス学会学術集会
    • Place of Presentation
      福岡国際会議場(福岡・福岡)
    • Year and Date
      2015-10-22
    • Related Report
      2015 Research-status Report
  • [Presentation] Akhisa Kato, Shinya Oda, Jun Arii, Yasushi Kawaguchi2015

    • Author(s)
      Phosphorylation of an HSV-1 Us8A promotes viral pathogenecity by regulating the ability of the virus to invade the CNS from peripheral sites.
    • Organizer
      第63回日本ウイルス学会学術集会
    • Place of Presentation
      福岡国際会議場(福岡・福岡)
    • Year and Date
      2015-10-22
    • Related Report
      2015 Research-status Report
  • [Presentation] RanBP10 acts like HSV-1 ICP0 in regulation of viral gene expression in infected cells.2015

    • Author(s)
      Yuka Sato, Akihisa Kato, Yuhei Maruzuru, Hirohata Yoshitaka, Shumpei Tsuda, Jun Arii, Yasushi Kawaguchi
    • Organizer
      第63回日本ウイルス学会学術集会
    • Place of Presentation
      福岡国際会議場(福岡・福岡)
    • Year and Date
      2015-10-22
    • Related Report
      2015 Research-status Report
  • [Presentation] p53 is a critical host regulator of Herpes simplex encephalitis.2015

    • Author(s)
      Yumei Maruzuru, Naoto Koyanagi, Jun Arii, Akihisa Kato, Yasushi Kawaguchi
    • Organizer
      第63回日本ウイルス学会学術集会
    • Place of Presentation
      福岡国際会議場(福岡・福岡)
    • Year and Date
      2015-10-22
    • Related Report
      2015 Research-status Report
  • [Presentation] Herpes simplex virus ICP22 interacts with viral nuclear egress factors UL31, UL34 and Us3, and regulates viral nuclear egress.2015

    • Author(s)
      Yuhei Maruzuru, Keiko Shindo, Zhuoming Liu, Masaaki Oyama, Hiroko Kozuka-Hata, Jun Arii, Akihisa Kato, Yasushi Kawaguchi
    • Organizer
      第14回あわじしま感染症・免疫フォーラム
    • Place of Presentation
      淡路夢舞台(兵庫・淡路)
    • Year and Date
      2015-09-08
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Function of hte herpes simplex virus 1 small capsid protein VP26 is regulated by phosphorylation at a specific site.2015

    • Author(s)
      Ryosuke Kobayashi, Akihisa Kato, Jun Arii, Yasuhi Kawaguchi
    • Organizer
      第14回あわじしま感染症・免疫フォーラム
    • Place of Presentation
      淡路夢舞台(兵庫・淡路)
    • Year and Date
      2015-09-08
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Multiple glycoproteins of herpes simplex virus 1 deform membrane for secondary envelopment2015

    • Author(s)
      Jun Arii, Akihisa Kato, Yasushi Kawaguchi
    • Organizer
      第14回あわじしま感染症・免疫フォーラム
    • Place of Presentation
      淡路夢舞台(兵庫・淡路)
    • Year and Date
      2015-09-08
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Phosphorylation of SNX3 induced the protection of HSV-1 protein from the lysosomal degradation for efficient neurovirulence.2015

    • Author(s)
      Akihisa Kato, Jun Arii, Yasuhi Kawaguchi
    • Organizer
      第14回あわじしま感染症・免疫フォーラム
    • Place of Presentation
      淡路夢舞台(兵庫・淡路)
    • Year and Date
      2015-09-08
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] RanBP10, a novel host cellular protein that interacts with a herpes simplex virus 1 (HSV-1) regulatory protein ICP0, regulates viral gene expression by acting like ICP0 in HSV-1 infected cells.2015

    • Author(s)
      Yuka Sato, Akihisa Kato, Yuhei Maruzuru, Yoshitaka Hirohata, Shumpei Tsuda, Jun Arii, Yasushi Kawaguchi
    • Organizer
      第14回あわじしま感染症・免疫フォーラム
    • Place of Presentation
      淡路夢舞台(兵庫・淡路)
    • Year and Date
      2015-09-08
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Down-regulation of a cytokine expression by HSV-1 UL13 protein kinase is critical for herpes encephalitis.2015

    • Author(s)
      Naoto Koyanagi, Takahiko Imai, Keiko Shindo, Jun Arii, Akihisa Kato, Yasushi Kawaguchi
    • Organizer
      第14回あわじしま感染症・免疫フォーラム
    • Place of Presentation
      淡路夢舞台(兵庫・淡路)
    • Year and Date
      2015-09-08
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Role of an interaction between two conserved tegument proteins in herpes simplex virus 1 (HSV-1) replication.2015

    • Author(s)
      Shinya Oda, Akihisa Kato, Jun Arii, Yasushi Kawaguchi
    • Organizer
      第14回あわじしま感染症・免疫フォーラム
    • Place of Presentation
      淡路夢舞台(兵庫・淡路)
    • Year and Date
      2015-09-08
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Elucidation of the type-specific differences in herpes simplex virus Us3 genes.2015

    • Author(s)
      Keiko Shindo, Akihisa Kato, Koyanagi Naoto, Jun Arii, Yasuhi Kawaguchi
    • Organizer
      第14回あわじしま感染症・免疫フォーラム
    • Place of Presentation
      淡路夢舞台(兵庫・淡路)
    • Year and Date
      2015-09-08
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Herpes simplex virus 1 recruits CD98 heavy chain and b1 integrin to the nuclear membrane for viral de-envelopment.2015

    • Author(s)
      Yoshitaka Hirohata, Jun Arii, Zhuoming Liu, Keiko Shindo, Masaaki Oyama, Hiroko Kozuka-Hata, Hiroshi Sagara, Akihisa Kato, Yasushi Kawaguchi
    • Organizer
      第14回あわじしま感染症・免疫フォーラム
    • Place of Presentation
      淡路夢舞台(兵庫・淡路)
    • Year and Date
      2015-09-08
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Role of host cell protein p32 in herpes simplex virsu 1 de-envelopment during viral nuclear egress.2015

    • Author(s)
      Zhuoming Liu, Akihsa Kato, Masaaki Oyama, Hiroko Kozuka-Hata, Jun Arii, Yasushi Kawaguchi
    • Organizer
      第14回あわじしま感染症・免疫フォーラム
    • Place of Presentation
      淡路夢舞台(兵庫・淡路)
    • Year and Date
      2015-09-08
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Herpes simplex virus 1 glycoproteins induce membrane deformation for efficient viral secondary envelopment.2015

    • Author(s)
      Jun Arii, Akihisa Kato, Yasushi Kawaguchi
    • Organizer
      40th annual international herpesvirus workshop
    • Place of Presentation
      Boise (USA)
    • Year and Date
      2015-06-25
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Identification of a host cell protein , RanBP10, which acts like ICP0 in HSV-1 infected cells.2015

    • Author(s)
      Yuka Sato, Akihisa Kato, Yuhei Maruzuru, Yoshitaka Hirohata, Shumpei Tsuda, Jun Arii, Yasushi Kawaguchi
    • Organizer
      40th annual international herpesvirus workshop
    • Place of Presentation
      Boise (USA)
    • Year and Date
      2015-06-25
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Elucidation of a critical interaction between the two conserved tegument proteins for HSV-1 secondary envelopment.2015

    • Author(s)
      Shinya Oda, Akihisa Kato, Yuichi Furuhata, Jun Arii, Yasushi Kawaguchi
    • Organizer
      40th annual international herpesvirus workshop
    • Place of Presentation
      Boise (USA)
    • Year and Date
      2015-06-25
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] HSV-1のウイルス増殖および病態発現はキャプシドタンパク質VP26のリン酸化によって制御される2015

    • Author(s)
      小林 亮介、加藤 哲久、有井 潤、川口 寧
    • Organizer
      第29回ヘルペスウイルス研究会
    • Place of Presentation
      長崎にっしょうかん(長崎・長崎)
    • Year and Date
      2015-06-04
    • Related Report
      2015 Research-status Report
  • [Presentation] 2型膜タンパク質Us8Aリン酸化の生物学的意義の解明2015

    • Author(s)
      加藤 哲久、尾田 信也、有井 潤、川口 寧
    • Organizer
      第29回ヘルペスウイルス研究会
    • Place of Presentation
      長崎にっしょうかん(長崎・長崎)
    • Year and Date
      2015-06-04
    • Related Report
      2015 Research-status Report
  • [Presentation] テグメント蛋白質UL51とUL14は複合体としてHSV-1最終エンベロープ獲得に寄与する2015

    • Author(s)
      尾田 真也、有井 潤、加藤 哲久、川口 寧
    • Organizer
      第29回ヘルペスウイルス研究会
    • Place of Presentation
      長崎にっしょうかん(長崎・長崎)
    • Year and Date
      2015-06-04
    • Related Report
      2015 Research-status Report
  • [Presentation] HSV-1の糖タンパク質は、膜変性引き起こすことで効率的なsecondary envelopmentに貢献する2015

    • Author(s)
      有井 潤、加藤 哲久、川口 寧
    • Organizer
      第29回ヘルペスウイルス研究会
    • Place of Presentation
      長崎にっしょうかん(長崎・長崎)
    • Year and Date
      2015-06-04
    • Related Report
      2015 Research-status Report
  • [Presentation] HSV-1感染細胞においてICP0と類似の機能をもつ宿主蛋白質RanBP10の同定2015

    • Author(s)
      佐藤 由佳,加藤 哲久,丸鶴 雄平,廣畑 吉崇,津田 峻平,有井 潤,川口 寧
    • Organizer
      第29回ヘルペスウイルス研究会
    • Place of Presentation
      長崎にっしょうかん(長崎・長崎)
    • Year and Date
      2015-06-04
    • Related Report
      2015 Research-status Report
  • [Book] 月刊細胞 2017年12月号 特 集 多様化する感染症研究 ウイルスとヒトとの共生関係2017

    • Author(s)
      有井 潤、川口 寧
    • Total Pages
      3
    • Publisher
      ニューサイエンス社
    • Related Report
      2017 Annual Research Report
  • [Remarks] 研究室のホームページ

    • URL

      http://www.ims.u-tokyo.ac.jp/kawaguchi-lab/KawaguchiLabTop.html

    • Related Report
      2017 Annual Research Report
  • [Remarks] 研究成果のプレスリリース

    • URL

      http://www.ims.u-tokyo.ac.jp/imsut/jp/research/papers/post_98.php

    • Related Report
      2017 Annual Research Report
  • [Remarks] 所属研究室のホームページ

    • URL

      http://www.ims.u-tokyo.ac.jp/kawaguchi-lab/publications.html

    • Related Report
      2016 Research-status Report

URL: 

Published: 2015-04-16   Modified: 2019-03-29  

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