Identification of receptor for cell-to-cell infection of HSV
| Project/Area Number |
15K15138
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Virology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Arii Jun 東京大学, 医科学研究所, 助教 (30704928)
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| Co-Investigator(Renkei-kenkyūsha) |
KAWAGUCHI Yasushi 東京大学, 医科学研究所, 教授 (60292984)
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| Research Collaborator |
KATO Akihisa 東京大学, 医科学研究所, 助教
KOYANAGI Naoto 東京大学, 医科学研究所, 特任研究員
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | HSV / glycoprotein / 膜タンパク質 / 細胞間感染 / ウイルス / レセプター / 細胞間伝播 / ヘルペスウイルス / 糖タンパク質 |
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| Outline of Final Research Achievements |
We investigated the mechanism of HSV cell-to-cell infection and identified new cellular factor which promotes cell-to-cell infection of HSV. This protein was interacted with viral gE, which is kwon to be important for cell-to-cell infection. Moreover, this protein was required for gE-dependent cell-to-cell infection. Thus, understanding of molecular mechanism of cell-to-cell infection of HSV may indicate new prophylactic and therapeutic approaches for the development of antiherpetic drugs.
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Report
(4 results)
Research Products
(82 results)
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[Journal Article] Herpes Simplex Virus 1 VP22 Inhibits AIM2-Dependent Inflammasome Activation to Enable Efficient Viral Replication.2018
Author(s)
Maruzuru, Y., T. Ichinohe, R. Sato, K. Miyake, T. Okano, T. Suzuki. T. Koshiba, N. Koyanagi, S. Tsuda, M. Watanabe, J. Arii, A. Kato, and Y. Kawaguchi.
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Journal Title
Cell Host Microbe
Volume: 23
Issue: 2
Pages: 254-265
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Y. Herpes simplex virus-1 evasion of CD8+ T cell accumulation contributes to viral encephalitis.2017
Author(s)
Koyanagi N, Imai T, Shindo K, Sato A, Fujii W, Ichinohe T, Takemura N, Kakuta S, Uematsu S, Kiyono H, Maruzuru Y, Arii J, Kato A, Kawaguchi Y.
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Journal Title
Journal of Clinical Investigation
Volume: 127
Pages: 3784-3795
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Interactome analysis of herpes simplex virus 1 envelope glycoprotein H. Hirohata Y, Kato A, Oyama M, Kozuka-Hata H, Koyanagi N, Arii J, Kawaguchi Y.2015
Author(s)
Y. Hirohata, A. Kato, M. Oyama, H. Kozuka-Hata, N. Koyanagi, J. Arii and Y. Kawaguchi.
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Journal Title
Microbiol. Immunol.
Volume: 印刷中
Pages: 331-337
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] ESCRT-III mediates HSV-1 Nuclear Egress2016
Author(s)
Jun Arii, Fumio Maeda, Akihisa Kato, Yasushi Kawaguchi
Organizer
41st Annual International Herpesvirus Workshop
Place of Presentation
Monona Terrace Community and Convention Center (Madison, Wisconsin, USA)
Year and Date
2016-07-23
Related Report
Int'l Joint Research
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