| Project/Area Number |
15K15138
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Virology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Arii Jun 東京大学, 医科学研究所, 助教 (30704928)
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| Co-Investigator(Renkei-kenkyūsha) |
KAWAGUCHI Yasushi 東京大学, 医科学研究所, 教授 (60292984)
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| Research Collaborator |
KATO Akihisa 東京大学, 医科学研究所, 助教
KOYANAGI Naoto 東京大学, 医科学研究所, 特任研究員
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | HSV / glycoprotein / 膜タンパク質 / 細胞間感染 / ウイルス / レセプター / 細胞間伝播 / ヘルペスウイルス / 糖タンパク質 |
|---|
| Outline of Final Research Achievements |
We investigated the mechanism of HSV cell-to-cell infection and identified new cellular factor which promotes cell-to-cell infection of HSV. This protein was interacted with viral gE, which is kwon to be important for cell-to-cell infection. Moreover, this protein was required for gE-dependent cell-to-cell infection. Thus, understanding of molecular mechanism of cell-to-cell infection of HSV may indicate new prophylactic and therapeutic approaches for the development of antiherpetic drugs.
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