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Establishment of in vitro infection system of hepatitis B virus and infection prevention

Research Project

Project/Area Number 15K15140
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Virology
Research InstitutionKanazawa University

Principal Investigator

KUROKI Kazuyuki  金沢大学, がん進展制御研究所, 准教授 (20178122)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
KeywordsB型肝炎ウイルス / HBV / iPS細胞 / 肝細胞 / ウイルス / 感染 / B型肝炎ウイルス
Outline of Final Research Achievements

Understanding the Life cycle of human hepatitis B virus (HBV), the causal virus of hepatitis and liver cancer, is important in exploring new ways to prevent the infection and proliferation of HBV. In this study, as a foothold to elucidate the molecular mechanism of hepatocyte-specific infection of HBV which is not well understood yet, and as a basis for anti-HBV drug discovery, we established HBV in vitro infection system with more efficient and reproducible effect on differentiated hepatocytes from newly prepared iPS cells.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (3 results)

All 2017 2015

All Presentation (3 results)

  • [Presentation] DMSOはiPS細胞より分化誘導した肝細胞へのHBV感染を高める2017

    • Author(s)
      黒木和之、志村瞳
    • Organizer
      第65回日本ウイルス学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] iPS細胞より分化誘導した肝細胞を用いたHBV in vitro 感染系2017

    • Author(s)
      黒木和之、志村瞳
    • Organizer
      第40回日本分子生物学会年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] iPS細胞より分化誘導した肝細胞とHBV感染2015

    • Author(s)
      黒木和之、志村瞳
    • Organizer
      第63回日本ウイルス学会学術集会
    • Place of Presentation
      福岡国際会議場(福岡市博多区)
    • Year and Date
      2015-11-22
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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