The role of a transcription factor TFEB in the innate immune system

Research Project

Project/Area Number	15K15148
Research Category	Grant-in-Aid for Challenging Exploratory Research
Allocation Type	Multi-year Fund
Research Field	Immunology
Research Institution	The University of Tokyo
Principal Investigator	MIYAKE Kensuke 東京大学, 医科学研究所, 教授 (60229812)
Project Period (FY)	2015-04-01 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000) Fiscal Year 2015: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Keywords	自然免疫 / Toll様受容体
Outline of Final Research Achievements	The present study focused on the role of a transcription factor TFEB, a master regulator of lysosomes, in Toll-like receptor (TLR) responses. In preliminary studies, TFEB overexpression upregulated TLR responses. However, overexpression by another expression vector did not activate TLR responses. Further study was therefore difficult to pursue. Instead, we focused on the role of mTOR, a regulator of TFEB, in TLR responses, and found that mTORC2 play a role in TLR3 responses.

Report

(2 results)