Identification of human DC and monocyte progenitors
| Project/Area Number |
15K15150
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Immunology
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
OHTEKI Toshiaki 東京医科歯科大学, 難治疾患研究所, 教授 (50233200)
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| Co-Investigator(Renkei-kenkyūsha) |
ONAI Nobuyuki 東京医科歯科大学, 難治疾患研究所, 講師 (50323605)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | ヒトcMop / 単球/マクロファージ / cGMP / rGMP / cMoP / GMP / プレ単球 / 単球 / マイクロアレイ / CDP / 樹状細胞 / マクロファージ |
|---|
| Outline of Final Research Achievements |
Dendritic cells and monocytes/macrophages are critically involved in host defense and tissue pathology under steady-state and inflammatory conditions. A common monocyte progenitor (cMoP) that is strictly committed to the monocyte lineage has been recently identified in mice. In this study, we identified human cMoPs as a CLEC12AhiCD64hi subpopulation of conventional granulocyte-monocyte progenitors (cGMPs) in umbilical cord blood and in bone marrow. Human cMoPs gave rise to monocyte subsets without showing any potential for differentiating into myeloid or lymphoid cells. Within the cGMP population, we also identified revised GMPs that completely lacked DC and lymphoid potential. Our findings expand and revise the current understanding of human myeloid cell differentiation pathways.
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Report
(3 results)
Research Products
(15 results)
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[Journal Article] Non-myeloablative preconditioning with ACK2 (anti-c-kit antibody) is efficient in bone marrow transplantation for murine models of mucopolysaccharidosis type II2016
Author(s)
Yokoi, T., Yokoi, K., Akiyama, K., Higuchi, T., Shimada, Y., Kobayashi, H., Sato, T., Ohteki, T., Otsu, M., Nakauchi, H., Ida, H. and Ohashi, T
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Journal Title
Mol Genet Meta
Volume: 119
Issue: 3
Pages: 232-238
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Cytosine-phosphorothionate- guanine oligodeoxynucleotides exacerbates hemophagocytosis by inducing tumor necrosis factor-α production in mice after bone marrow transplanation.2016
Author(s)
Liu J, Guo YM, Onai N, Ohyagi H, Hirokawa M, Takahashi N, Tagawa H, Ubukawa K, Kobayahi I, Tezuka H, Minamiya Y, Ohteki T, and Sawada K.
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Journal Title
Biol Blood Marrow Transplant 2015
Volume: 印刷中
Issue: 4
Pages: 627-636
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Bacterial c-di-GMP affects hematopoietic stem/progenitors and their niches through STING.2015
Author(s)
Kobayashi H, Kobayashi CI, Nakamura-Ishizu A, Karigane D, Haeno H, Yamamoto KN, Sato T, Ohteki T, Hayakawa Y, Barber GN, Kurokawa M, Suda T, and Takubo K.
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Journal Title
Cell Reports
Volume: 111
Issue: 1
Pages: 71-84
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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