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Functional analysis of neurotransmitter-producing lymphocytes

Research Project

Project/Area Number 15K15153
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Immunology
Research InstitutionOsaka University

Principal Investigator

Suzuki Kazuhiro  大阪大学, 免疫学フロンティア研究センター, 特任准教授(常勤) (60611035)

Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords免疫学 / リンパ球 / 神経伝達物質
Outline of Final Research Achievements

We had previously revealed a mechanism by which noradrenaline, the principal neurotransmitter released from adrenergic nerves, controls lymphocyte exit from lymph nodes. Additionally, we had found that fractions of B cells and myeloid cells are capable of producing noradrenaline. This research project aimed to clarify the role of these noradrenaline-producing immune cells in the control of lymphocyte trafficking. To this end, we generated B cell- or myeloid cell-specific knockout mice lacking the gene encoding a noradrenaline-synthesizing enzyme. However, these mutant mice showed no alterations in lymphocyte exit from lymph nodes. These observations suggest that noradrenaline derived from these immune cells makes little contribution to this aspect of the immune system.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • Research Products

    (30 results)

All 2017 2016 2015 Other

All Int'l Joint Research (1 results) Journal Article (7 results) (of which Peer Reviewed: 3 results,  Open Access: 2 results,  Acknowledgement Compliant: 3 results) Presentation (15 results) (of which Int'l Joint Research: 6 results,  Invited: 15 results) Book (1 results) Remarks (6 results)

  • [Int'l Joint Research] I.G.B.M.C.(France)

    • Related Report
      2015 Research-status Report
  • [Journal Article] Control of lymphocyte trafficking and adaptive immunity by adrenergic nerves2017

    • Author(s)
      Suzuki, K. and Nakai, A.
    • Journal Title

      Clin. Exp. Neuroimmunol.

      Volume: 8 Issue: 1 Pages: 15-22

    • DOI

      10.1111/cen3.12376

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Adrenergic control of the adaptive immune response by diurnal lymphocyte recirculation through lymph nodes2016

    • Author(s)
      Suzuki, K., Hayano, Y., Nakai, A., Furuta, F. and Noda, M.
    • Journal Title

      J. Exp. Med.

      Volume: 213 Issue: 12 Pages: 2567-2574

    • DOI

      10.1084/jem.20160723

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Autonomic control of inflammation2016

    • Author(s)
      Suzuki, K. and Nakai, A.
    • Journal Title

      Clin. Exp. Neuroimmunol.

      Volume: 7 Issue: 1 Pages: 10-17

    • DOI

      10.1111/cen3.12292

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] 交感神経による免疫細胞動態の制御2016

    • Author(s)
      鈴木 一博
    • Journal Title

      最新医学

      Volume: 71 Pages: 17-21

    • NAID

      40022418462

    • Related Report
      2015 Research-status Report
  • [Journal Article] 交感神経を介した免疫細胞の動態制御2015

    • Author(s)
      鈴木 一博
    • Journal Title

      感染・炎症・免疫

      Volume: 45 Pages: 69-70

    • Related Report
      2015 Research-status Report
  • [Journal Article] Control of immune cell dynamics by the sympathetic nervous system2015

    • Author(s)
      鈴木 一博
    • Journal Title

      Leading Author's

      Volume: 4 Pages: e011

    • DOI

      10.7875/leading.author.4.e011

    • Related Report
      2015 Research-status Report
  • [Journal Article] 交感神経によるリンパ球の動態調節2015

    • Author(s)
      鈴木 一博
    • Journal Title

      炎症と免疫

      Volume: 23 Pages: 114-118

    • Related Report
      2015 Research-status Report
  • [Presentation] Control of lymphocyte trafficking and adaptive immune responses by adrenergic nerves2017

    • Author(s)
      Suzuki, K.
    • Organizer
      The 6th NIF Winter School on Advanced Immunology
    • Place of Presentation
      Grand Copthorne Waterfront Hotel, Singapore
    • Year and Date
      2017-01-22
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Control of lymphocyte trafficking by adrenergic nerves2016

    • Author(s)
      Suzuki, K.
    • Organizer
      The 45th Annual Meeting of the Japanese Society for Immunology
    • Place of Presentation
      Laguna Garden Hotel, Ginowan, Okinawa, Japan
    • Year and Date
      2016-12-05
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Overview talk: neuro-immune interactions2016

    • Author(s)
      Suzuki, K.
    • Organizer
      The 45th Annual Meeting of the Japanese Society for Immunology
    • Place of Presentation
      Laguna Garden Hotel, Ginowan, Okinawa, Japan
    • Year and Date
      2016-12-05
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 交感神経によるリンパ球動態と免疫応答の制御2016

    • Author(s)
      鈴木一博
    • Organizer
      第3回六甲医学研究会
    • Place of Presentation
      淡路夢舞台国際会議場,淡路市,兵庫県
    • Year and Date
      2016-10-28
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 交感神経によるリンパ球の動態制御とその免疫応答における意義2016

    • Author(s)
      鈴木一博
    • Organizer
      千里ライフサイエンスセミナー
    • Place of Presentation
      千里ライフサイエンスセンター,豊中市,大阪府
    • Year and Date
      2016-05-31
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 交感神経によるリンパ球の動態制御2016

    • Author(s)
      鈴木 一博
    • Organizer
      膜生物学・医学学術講演会
    • Place of Presentation
      神戸大学大学院医学系研究科・医学部,神戸市,兵庫県
    • Year and Date
      2016-03-03
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] Adrenergic control of lymphocyte recirculation through lymph nodes2016

    • Author(s)
      Suzuki, K.
    • Organizer
      The 7th IFReC Symposium “Immunology at the Forefront”
    • Place of Presentation
      Knowledge Theater at Grand Front Osaka, Osaka, Japan
    • Year and Date
      2016-01-21
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 交感神経系によるリンパ球動態の制御メカニズム2015

    • Author(s)
      鈴木 一博
    • Organizer
      第38回日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド,神戸市,兵庫県
    • Year and Date
      2015-12-01
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 交感神経によるリンパ球動態と炎症の制御2015

    • Author(s)
      鈴木 一博
    • Organizer
      第43回日本臨床免疫学会総会
    • Place of Presentation
      神戸国際会議場,神戸市,兵庫県
    • Year and Date
      2015-10-22
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] β2アドレナリン受容体を介したリンパ球動態の制御機構2015

    • Author(s)
      鈴木 一博
    • Organizer
      BioJapan 2015
    • Place of Presentation
      パシフィコ横浜,横浜市,神奈川県
    • Year and Date
      2015-10-14
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 神経系と免疫系:「病は気から」のメカニズム2015

    • Author(s)
      鈴木 一博
    • Organizer
      JST市民公開講座
    • Place of Presentation
      富山県民会館,富山市,富山県
    • Year and Date
      2015-10-03
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] Control of lymphocyte trafficking and inflammation through β2-adrenergic receptors2015

    • Author(s)
      Suzuki, K.
    • Organizer
      The 4th CSI/JSI/KAI Joint Symposium on Immunology
    • Place of Presentation
      Jinling Guanyuan International Hotel, Suzhou, China
    • Year and Date
      2015-09-20
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 交感神経系による免疫調節のメカニズム2015

    • Author(s)
      鈴木 一博
    • Organizer
      GSK皮膚免疫カンファレンス
    • Place of Presentation
      大津プリンスホテル,大津市,滋賀県
    • Year and Date
      2015-07-26
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 交感神経による免疫調節のメカニズム2015

    • Author(s)
      鈴木 一博
    • Organizer
      第17回免疫サマースクール
    • Place of Presentation
      淡路夢舞台国際会議場,淡路市,兵庫県
    • Year and Date
      2015-07-21
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] Control of lymphocyte dynamics by adrenergic nerves.2015

    • Author(s)
      Suzuki, K.
    • Organizer
      NCNP Neuroimmunology International Symposium
    • Place of Presentation
      National Center of Neurology and Psychiatry, Kodaira, Tokyo
    • Year and Date
      2015-06-10
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research / Invited
  • [Book] Chronic Inflammation: Mechanisms and Regulation2016

    • Author(s)
      Suzuki, K.
    • Total Pages
      695
    • Publisher
      Springer Japan
    • Related Report
      2016 Annual Research Report
  • [Remarks] 論文がJ. Exp. Med.に掲載されました。

    • URL

      http://kazuhirosuzuki.com/?p=1219

    • Related Report
      2016 Annual Research Report
  • [Remarks] 研究成果が各種メディアで取り上げられました。

    • URL

      http://kazuhirosuzuki.com/?p=1271

    • Related Report
      2016 Annual Research Report
  • [Remarks] 論文がScience Signalingで取り上げられました。

    • URL

      http://kazuhirosuzuki.com/?p=1344

    • Related Report
      2016 Annual Research Report
  • [Remarks] 論文がF1000で取り上げられました。

    • URL

      http://kazuhirosuzuki.com/?p=1367

    • Related Report
      2016 Annual Research Report
  • [Remarks] 交感神経による免疫応答の日内変動を発見

    • URL

      http://www.ifrec.osaka-u.ac.jp/jpn/research/20161101-1000.htm

    • Related Report
      2016 Annual Research Report
  • [Remarks] 鈴木研究室ホームページ

    • URL

      http://kazuhirosuzuki.com/

    • Related Report
      2015 Research-status Report

URL: 

Published: 2015-04-16   Modified: 2018-03-22  

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