| Project/Area Number |
15K15156
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Immunology
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| Research Institution | Kagoshima University |
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Principal Investigator |
Hara Hiromitsu 鹿児島大学, 医歯学域医学系, 教授 (20392079)
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| Co-Investigator(Kenkyū-buntansha) |
李 花 鹿児島大学, 学術研究院医歯学域医学系, 助教 (70597517)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | アレルギー / 免疫学 / 接触皮膚炎 / ITAM / 自然免疫 |
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| Outline of Final Research Achievements |
Since the activation of dendritic cells by allergic compounds (haptens) depends on the ITAM-Syk-CARD9 signal, we searched for myeloid ITAM-coupled receptors that recognize haptens. As a result, we found a plurality of ITAM coupled receptors showing binding properties to various haptens（TNCB、DNCB、oxazolon、FITC). Among them, focusing on two Ig superfamily receptors (called IgR2, IgR5) that associate with DAP12 and recognize multiple haptens, we investigated their ability of ITAM signal activation by using receptor-expressing NFAT-GFP reporter cells. As a result, both IgR2 and IgR5 activated the ITAM signal by hapten stimulation . Therefore, these two were identified as hapten receptors.
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