| Project/Area Number |
15K15186
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Applied pharmacology
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| Research Institution | Kyoto Prefectural University |
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Principal Investigator |
Miyazaki Kohji 京都府立大学, 生命環境科学研究科, 准教授 (60254322)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 創傷被覆材 / 化膿創傷 / 治癒効果 / 黄色ブドウ球菌 / 毒素産生 |
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| Outline of Final Research Achievements |
Wound healing is hastened by the wound dressing of wet type. But this type cannot be applied to suppurative wound. Although a wound dressing containing antimicrobial agent is developed, wound healing is delayed because of its cytotoxicity. We found an inhibitor, which depresses toxin production by pathogenic bacteria without bactericidal activity. This compound does not exhibit cytotoxicity. Therefore, the wound dressing contained this inhibitor was prepared by soaking in 3 mM solution of the inhibitor and air drying. This dressing was plastered to the suppurative wound of immunodeficient hairless mouse, and its healing effect was examined. As the result, after 3 days from plaster, healing of suppurative wound was notably improved. Then both of enhancement of wound healing and depression of infection are achieved.
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