Development of diagnostic method for lifestyle-related disease risk targeting peripheral blood mononuclear cells
| Project/Area Number |
15K15192
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Laboratory medicine
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| Research Institution | Osaka University |
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Principal Investigator |
Kihara Shinji 大阪大学, 医学系研究科, 教授 (20332736)
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| Co-Investigator(Kenkyū-buntansha) |
山本 浩靖 大阪大学, 医学系研究科, 助教 (00631201)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 分析科学 / 蛋白質 / 医療・福祉 / 細胞・組織 / マイクロアレイ / 医療･福祉 / 細胞･組織 |
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| Outline of Final Research Achievements |
Based on the mRNA microarray analysis of peripheral blood mononuclear cells before and after meal load, we identified suppressor of cytokine signaling (SOCS) 1 and SOCS 3 and inflammation control secretory protein factor A (unpublished data) as a molecule group responsive to oxidative stress occurring after meal.
Measurement of these factors might be expected to become a new index to evaluate chronic inflammation leading to lifestyle-related diseases.
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Report
(3 results)
Research Products
(1 results)
