Control of amyloid neuropathy from the aspect of inflammation
Project/Area Number |
15K15195
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Laboratory medicine
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Research Institution | Kumamoto University |
Principal Investigator |
ANDO Yukio 熊本大学, 大学院生命科学研究部(医), 教授 (20253742)
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Co-Investigator(Kenkyū-buntansha) |
田崎 雅義 熊本大学, 大学院生命科学研究部(保), 助教 (50613402)
植田 光晴 熊本大学, 医学部附属病院, 講師 (60452885)
三隅 洋平 熊本大学, 大学院生命科学研究部(医), 助教 (80625781)
山下 太郎 熊本大学, 医学部附属病院, 特任教授 (90381003)
大林 光念 熊本大学, 大学院生命科学研究部(保), 教授 (90361899)
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Project Period (FY) |
2015-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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Keywords | 家族性アミロイドポリニューロパチー / トランスサイレチン / 炎症 / サイトカイン / マクロファージ / アミロイド沈着機構 / インターロイキン / 免疫細胞 / 臨床化学 |
Outline of Final Research Achievements |
To elucidate the role of inflammation on the pathogensis of familial amyloid polyneuropathy (FAP), we measured the concentrations of various kinds of cytokines, and counted the T, B and monocytes in the peripheral blood in FAP patients and controls. Those analyses revealed activated inflammatosome, such as inflammatory related cytokines, and monocytes secreted IL-1β and IL-6. NO significant results were obtained in the compliment association in those analyses. Immunohistochemical analyses revealed that, M2 macrophages might play an important role in the amyloidogenesis of this disease in compared to immunohistochemical findings in controls, those in FAP patients.
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Report
(3 results)
Research Products
(74 results)
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[Journal Article] Clinicopathological and biochemical findings of thyroid amyloid in hereditary transthyretin amyloidosis with and without liver transplantation.2017
Author(s)
Huang G, Ueda M, Tasaki M, Yamashita T, Misumi Y, Masuda T, Suenaga G, Inoue Y, Kinoshita Y, Matsumoto S, Mizukami M, Tsuda Y, Nomura T, Obayashi K, Ando Y
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Journal Title
Amyloid
Volume: 印刷中
Issue: 1
Pages: 1-6
DOI
Related Report
Peer Reviewed
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[Journal Article] Light Chain Deposition Disease Diagnosed with Laser Micro-dissection, Liquid Chromatography, and Tandem Mass Spectrometry of Nodular Glomerular Lesions2017
Author(s)
Kasagi T, Nobata H, Suzuki K, Miura N, Banno S, Takami A, Yamashita T, Ando Y, Imai H
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Journal Title
Internal Medicine
Volume: 56
Issue: 1
Pages: 61-66
DOI
NAID
ISSN
0918-2918, 1349-7235
Related Report
Peer Reviewed / Open Access
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[Journal Article] Knee osteoarthritis associated with different kinds of amyloid deposits and the impact of aging on type of amyloid.2016
Author(s)
Yanagisawa A, Ueda M, Sueyoshi T, Nakamura E, Tasaki M, Suenaga G, Motokawa H, Toyoshima R, Kinoshita Y, Misumi Y, Yamashita T, Sakaguchi M, Westermark P, Mizuta H, Ando Y.
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Journal Title
Amyloid
Volume: 23
Issue: 1
Pages: 26-32
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Labial salivary gland biopsy for diagnosing immunoglobulin light chain amyloidosis: a retrospective analysis.2016
Author(s)
Suzuki T, Kusumoto S, Yamashita T, Masuda A, Kinoshita S, Yoshida T, Takami-Mori F, Takino H, Ito A, Ri M, Ishida T, Komatsu H, Ueda M, Ando Y, Inagaki H, Iida S.
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Journal Title
Annals of Hematology
Volume: 95 (2)
Issue: 2
Pages: 279-285
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Long-term outcome of patients with hereditary transthyretin V30M amyloidosis with polyneuropathy after liver transplantation.2016
Author(s)
Okumura K, Yamashita T, Masuda T, Misumi Y, Ueda A, Ueda M, Obayashi K, Jono H, Yamashita S, Inomata Y, Ando Y.
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Journal Title
Amyloid
Volume: 23
Issue: 1
Pages: 39-45
DOI
Related Report
Peer Reviewed
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[Journal Article] Phase 1 study of bortezomib in combination with melphalan and dexamethasone in Japanese patients with relapsed AL amyloidosis.2016
Author(s)
Shimazaki C, Fuchida S, Suzuki K, Ishida T, Imai H, Sawamura M, Takamatsu H, Abe M, Miyamoto T, Hata H, Yamada M, Ando Y
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Journal Title
Int J Hematol
Volume: 103
Issue: 1
Pages: 79-85
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Effects of tafamidis treatment on transthyretin (TTR) stabilization, efficacy, and safety in Japanese patients with familial amyloid polyneuropathy (TTR-FAP) with Val30Met and non-Varl30Met: A phase III, open-label study.2016
Author(s)
Ando Y, Sekijima Y, Obayashi K, Yamashita T, Ueda M, Misumi Y, Morita H, Machii K, Ohta M, Takata A, Ikeda S.
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Journal Title
J Neurol Sci
Volume: 362
Pages: 266-271
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Endoscopic Findings of Small-Bowel Lesions in Familial Amyloid Polyneuropathy: A Case Report.2016
Author(s)
Asakura K, Yanai S, Nakamura S, Kawaski K, Eizuka M, Ishida K, Sugai T, Ueda M, Yamashita T, Ando Y, Matsumoto T.
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Journal Title
Medicine (Baltimore)
Volume: 95(11)
Issue: 11
Pages: e2896-e2896
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Sources of variation of transthyretin in healthy subjects in East and Southeast Asia: Clinical and experimental evidence for the effect of alcohol on transthyretin metabolism.2016
Author(s)
Jono H, Su Y, Obayashi K, Tanaka Y, Ishiguro A, Nishimura H, Shinriki S, Ueda M, Ikeda K, Yamagata K, Ichihara K, Ando Y; Scientific Committee for the Asia-Pacific Federation of Clinical Biochemistry.
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Journal Title
Clin Chim Acta
Volume: 458
Pages: 240-5
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Hereditary amyloidosis with cardiomyopathy caused by the novel variant transthyretin A36D.2016
Author(s)
Yamashita T, Ueda M, Saga N, Nanto K, Tasaki M, Masuda T, Misumi Y, Oda S, Fujimoto A, Amano T, Takamatsu K, Yamashita S, Obayashi K, Matsui H, Ando Y.
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Journal Title
Amyloid
Volume: in press
Issue: 3
Pages: 207-208
DOI
Related Report
Peer Reviewed
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[Journal Article] Involvement of macrophages in the pathogenesis of familial amyloid polyneuropathy and efficacy of human iPS cell-derived macrophages in its treatment.2016
Author(s)
Suenaga G, Ikeda T, Komohara Y, Takamatsu K, Kakuma T, Tasaki M, Misumi Y, Ueda M, Ito T, Senju S, Ando Y
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Journal Title
PLoS One
Volume: 11
Issue: 10
Pages: e0163944-e0163944
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Novel antibody for the treatment of transthyretin amyloidosis.2016
Author(s)
Hosoi A, Su Y, Torikai M, Jono H, Ishikawa D, Soejima K, Higuchi H, Guo J, Ueda M, Suenaga G, Motokawa H, Ikeda T, Senju S, Nakashima T, Ando Y
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Journal Title
J Biol Chem
Volume: 25
Issue: 48
Pages: 25096-25105
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Rapid detection of wild-type and mutated transthyretins.2015
Author(s)
Tasaki M, Ueda M, Obayashi K, Motokawa H, Kinoshita Y, Suenaga G, Yanagisawa A, Toyoshima R, Misumi Y, Masuda T, Yamashita T, Ando Y
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Journal Title
Annals of Clinical Biochemistry
Volume: epub
Issue: 4
Pages: 508-510
DOI
Related Report
Peer Reviewed
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[Journal Article] Two brothers homozygous for the TTR V30M both presenting with a phenotype dominated by central nervous complications.2015
Author(s)
Uchida Y, Takada K, Tsugu Y, Ueda M, Yamashita T, Ando Y, Kobayashi S, Koike H, Watanabe T, Matsumoto T, Toyoda T, Yamada G, Matsukawa N.
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Journal Title
Amyloid
Volume: 22
Issue: 4
Pages: 261-262
DOI
Related Report
Peer Reviewed
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[Presentation] Role of C-terminal portion of transthyretin on amyloid formation2016
Author(s)
Ueda M, Mizuguchi M, Misumi Y, Tasaki M, Suenaga G, Matsumoto S, Mizukami M, Masuda T, Yamashita T, Kluve-Beckerman B, Liepnieks JJ, Benson MD, Ando Y
Organizer
XVth International Symposium on amyloidosis, Uppsala
Place of Presentation
Uppsala, Sweden
Year and Date
2016-07-03
Related Report
Int'l Joint Research
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[Presentation] Occurrence factors and clinical picture of iatrogenic transthyretin amyloidosis after domino liver transplantation,2016
Author(s)
Misumi Y, Oshima T, Ueda M, Yamashita T, Tasaki M, Masuda T, Obayashi K, Ando Y
Organizer
XVth International Symposium on amyloidosis, Uppsala
Place of Presentation
Uppsala, Sweden
Year and Date
2016-07-03
Related Report
Int'l Joint Research
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[Presentation] Multiple nodular pulmonary and subcutaneous amyloidosis associated with Sjögren syndrome.2016
Author(s)
Kinoshita Y, Misumi Y, Ueda M, Tasaki M, Masuda T, Suenaga G, Inoue Y, Obayashi K, Yamashita T, Ando Y
Organizer
XVth International Symposium on amyloidosis, Uppsala
Place of Presentation
Uppsala, Sweden
Year and Date
2016-07-03
Related Report
Int'l Joint Research
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[Presentation] Amyloid formation of C-terminal portion of transthyretin.2016
Author(s)
Ueda M, Mizuguchi M, Misumi Y, Masuda T, Tasaki M, Suenaga G, Inoue Y, Tsuda Y, Nomura T, Kinoshita Y, Matsumoto S, Mizukami M, Yamashita T, Ando Y
Organizer
第57回日本神経学会学術大会
Place of Presentation
神戸
Year and Date
2016-05-18
Related Report
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[Presentation] Acquired systemic transthyretin amyloid deposits in a case with domino liver transplantation: an autopsy study.2015
Author(s)
Guannan Huang, Mitsuharu Ueda, Masayoshi Tasaki, Yohei Misumi, Teruaki Masuda, Yasuteru Inoue, Genki Suenaga, Hiroaki Motokawa, Risa Toyoshima, Yumiko Kinoshita, Konen Obayashi, Taro Yamashita, Yukio Ando
Organizer
第3回日本アミロイドーシス研究会学術集会
Place of Presentation
東京
Year and Date
2015-08-21
Related Report
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