| Project/Area Number |
15K15195
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Laboratory medicine
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| Research Institution | Kumamoto University |
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Principal Investigator |
ANDO Yukio 熊本大学, 大学院生命科学研究部(医), 教授 (20253742)
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| Co-Investigator(Kenkyū-buntansha) |
田崎 雅義 熊本大学, 大学院生命科学研究部(保), 助教 (50613402)
植田 光晴 熊本大学, 医学部附属病院, 講師 (60452885)
三隅 洋平 熊本大学, 大学院生命科学研究部(医), 助教 (80625781)
山下 太郎 熊本大学, 医学部附属病院, 特任教授 (90381003)
大林 光念 熊本大学, 大学院生命科学研究部(保), 教授 (90361899)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 家族性アミロイドポリニューロパチー / トランスサイレチン / 炎症 / サイトカイン / マクロファージ / アミロイド沈着機構 / インターロイキン / 免疫細胞 / 臨床化学 |
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| Outline of Final Research Achievements |
To elucidate the role of inflammation on the pathogensis of familial amyloid polyneuropathy (FAP), we measured the concentrations of various kinds of cytokines, and counted the T, B and monocytes in the peripheral blood in FAP patients and controls. Those analyses revealed activated inflammatosome, such as inflammatory related cytokines, and monocytes secreted IL-1β and IL-6. NO significant results were obtained in the compliment association in those analyses. Immunohistochemical analyses revealed that, M2 macrophages might play an important role in the amyloidogenesis of this disease in compared to immunohistochemical findings in controls, those in FAP patients.
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