Identification of the pathologically-transited immature cells diagnosed by soluble LR11
| Project/Area Number |
15K15198
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Laboratory medicine
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| Research Institution | Toho University |
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Principal Investigator |
BUJO Hideaki 東邦大学, 医学部, 教授 (80291300)
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| Co-Investigator(Renkei-kenkyūsha) |
JIANG Meizi 東邦大学, 医学部, 非常勤研究生 (00624066)
SHIMIZU Naomi 東邦大学, 医学部, 講師 (30375802)
HIRUTA Nobuyuki 東邦大学, 医学部, 准教授 (50201736)
NAGAO Tateki 東邦大学, 医学部, 教授 (20167555)
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| Research Collaborator |
NAKASEKO Chiaki 千葉大学, 医学部, 准教授 (30323398)
IKEUCHI Takeshi 新潟大学, 医学部, 教授 (20372469)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 可溶性 / ＬＲ１１ / 病的細胞 / 検査マーカー / リンパ腫 / 肺高血圧症 / アルツハイマー病 / LR11 / 肺高血圧 / 黄斑前膜 / 褐色脂肪 / 基礎代謝 / 熱産生 |
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| Outline of Final Research Achievements |
This study was aimed to identify pathological transition of the immature cells diagnosed by soluble LR11 (sLR11). The role and significance of sLR11 was investigated in three types of diseases with increased circulating sLR11 levels. The malignant transition of hematological cells was detected in the diagnosis of patients with diffuse large B-cell lymphoma. sLR11 was also important as a marker of pathological smooth muscle cells in pulmonary hypertension. The significance of sLR11 for the early diagnosis of Alzheimer’s disease will be further investigated by analysis using the patients’ samples. Thus, sLR11 was identified as a key regulator and a biomarker for the transition to pathological cells in heterogeneous diseases.
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Report
(3 results)
Research Products
(5 results)
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[Journal Article] Prognostic impact of serum soluble LR11 in newly diagnosed diffuse large B-cell lymphoma: A multicenter prospective analysis.2016
Author(s)
Sugita Y, Ohwada C, Kawaguchi T, Muto T, Tsukamoto S, Takeda Y1, Mimura N, Takeuchi M , Sakaida E, Shimizu N, Tanaka H, Abe D, Fukazawa M, Sugawara T, Aotsuka N, Nishiwaki K, Shono K, Ebinuma H, Fujimura K, Bujo H, Yokote K, Nakaseko C.
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Journal Title
Clin Chim Acta.
Volume: 463
Pages: 47-52
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Deletion of LR11 attenuates hypoxia-induced pulmonary arterial smooth muscle cell proliferation with medial thickening in mice.2016
Author(s)
Jiang L, Konishi H, Nurwidya F, Satoh K, Takahashi F, Ebinuma H, Fujimura K, Takasu K, Jiang M, Shimokawa H, Bujo H, Daida H.
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Journal Title
Arterioscler Thromb Vasc Biol.
Volume: 36
Issue: 9
Pages: 1972-1979
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Prognostic impact of circulating soluble LR11 on long-term clinical outcomes in patients with coronary artery disease2016
Author(s)
Ogita M, Miyauchi K, Kasai T, Tsuboi S, Wada H, Naito R, Konishi H, Dohi T, Tamura H, Okazaki S, Yanagisawa N, Shimada K, Suwa S, Jiang M, Bujo H, Daida H
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Journal Title
Atherosclerosis
Volume: 244
Pages: 216-221
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Serum soluble LR11, a novel tumor derived biomarker associated with the outcome of patients with diffuse large B-cell lymphoma.2015
Author(s)
Ohwada C, Yamazaki A, Kawaguchi T, Sugita Y, Takeuchi M, Shimizu N, Sakaida E, Takeda Y, Tsukamoto S, Muto T, Jiang M, Higashi M, Yokote K, Tamaru JI, Bujo H, Nakaseko C.
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Journal Title
Leuk Lymphoma.
Volume: 印刷中
Issue: 10
Pages: 1-4
DOI
Related Report
Peer Reviewed / Open Access
