| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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| Outline of Final Research Achievements |
To obtain monoclonal antibodies that recognize cancer-associated core fucosylation in glycoproteins, we examined application of our established immunity inducing method using artificial glycosphingolipid as immunogen. Particularly in this project, we have prepared two species of core fucosylated artificial glycosphingolipids and developed a screening method for obtaining the anti-core fucosylated glycoprotein antibody. On the other hand, we have obtained a monoclonal anti-glycosphingolipid IgG and found new activity of specific inhibitors for cellular β-hexosaminidases in this project.
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