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A new approach for the understand of neural mechanisms underlying the intractable pruritus

Research Project

Project/Area Number 15K15202
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Pain science
Research InstitutionOkayama University

Principal Investigator

SAKAMOTO Hirotaka  岡山大学, 自然科学研究科, 准教授 (20363971)

Co-Investigator(Kenkyū-buntansha) 高浪 景子  岡山大学, 自然科学研究科, 特別研究員(RPD) (70578830)
歌 大介  富山大学, 大学院医学薬学研究部(薬学), 助教 (70598416)
Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywordsガストリン放出ペプチド (GRP) / GRP受容体 / 痒み / 難治性掻痒症 / 霊長類 / 遺伝子改変ラット / 脊髄 / 三叉神経系 / GRP受容体 / ガストリン放出ペプチド(GRP)
Outline of Final Research Achievements

Itch or pruritus has been defined as an unpleasant sensation of the skin that provokes the urge to scratch in order to relieve the stress of itch. Itch followed by scratching worsens skin inflammation, inducing an itch-scratch cycle. Important findings have recently demonstrated that spinal itch transmission is independent of pain transmission and relies on gastrin-releasing peptide (GRP)/GRP receptor signalling in the dorsal horn of the spinal cord, as well as in the trigeminal sensory system in the medulla oblongata. We have recently generated a transgenic rat expressing the red fluorescent protein under control of the GRPR promoter. In this study, we used this transgenic rat model to examine the GRPR system in vivo in rodents. On the other hand, macaque monkeys appear to be an excellent model because they are close primate relatives to humans. Therefore, in this study, we also worked to identify this GRP system in primates using the Japanese macaque monkey (Macaca fuscata).

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • Research Products

    (76 results)

All 2017 2016 2015 Other

All Journal Article (19 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 19 results,  Open Access: 14 results,  Acknowledgement Compliant: 10 results) Presentation (51 results) (of which Int'l Joint Research: 7 results,  Invited: 16 results) Book (3 results) Remarks (3 results)

  • [Journal Article] Identification of the sexually dimorphic gastrin-releasing peptide system in the lumbosacral spinal cord that controls male reproductive function in the mouse and Asian house musk shrew (Suncus murinus).2017

    • Author(s)
      Tamura K, Kobayashi Y, Hirooka A, Takanami K, Oti T, Jogahara T, Oda SI, Sakamoto T, Sakamoto H
    • Journal Title

      J Comp Neurol

      Volume: 525 Issue: 7 Pages: 1586-1598

    • DOI

      10.1002/cne.24138

    • NAID

      120006463733

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Decrease in neuronal spine density in the postpartum period in the amygdala and bed nucleus of the stria terminalis in rat2017

    • Author(s)
      S Matsuo, KI Matsuda, K Takanami, T Mori, M Tanaka, M Kawata, J Kitawaki
    • Journal Title

      Neuroscience Letters

      Volume: 641 Pages: 21-25

    • DOI

      10.1016/j.neulet.2017.01.040

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comparative Anatomy of Gastrin-releasing Peptide Pathways in the Trigeminal Sensory System of Mouse and the Asian House Musk Shrew <i>Suncus murinus</i>2016

    • Author(s)
      K Takanami, K Inoue, H Mukai, K Tamura, T Jogahara, S Oda, M Kawata, T Sakamoto, and H Sakamoto
    • Journal Title

      ACTA HISTOCHEMICA ET CYTOCHEMICA

      Volume: 49 Issue: 6 Pages: 181-190

    • DOI

      10.1267/ahc.16030

    • NAID

      130006856396

    • ISSN
      0044-5991, 1347-5800
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Principal function of mineralocorticoid signaling suggested by constitutive knockout of the mineralocorticoid receptor in medaka fish.2016

    • Author(s)
      Sakamoto, T., Yoshiki, M., Takahashi, H., Yoshida, M., Ogino, Y., Ikeuchi, T., Nakamachi, T., Konno, N., Matsuda, K. and Sakamoto, H.
    • Journal Title

      Scientific Reports

      Volume: - Issue: 1 Pages: 37991-37991

    • DOI

      10.1038/srep37991

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Postnatal development of the gastrin-releasing peptide system in the lumbosacral spinal cord controlling male reproductive function in rats2016

    • Author(s)
      Katayama et al.
    • Journal Title

      Proceedings of the Japan Academy, Ser. B, Physical and Biological Sciences

      Volume: 92 Issue: 1 Pages: 69-75

    • DOI

      10.1186/s13293-016-0058-x

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Expression of Sex Steroid Hormone Receptors in Vagal Motor Neurons Innervating the Trachea and Esophagus in Mouse2016

    • Author(s)
      Mukudai et al.
    • Journal Title

      ACTA HISTOCHEMICA ET CYTOCHEMICA

      Volume: 49 Issue: 1 Pages: 37-46

    • DOI

      10.1267/ahc.15037

    • NAID

      130005128328

    • ISSN
      0044-5991, 1347-5800
    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Activation of supraoptic oxytocin neurons by secretin facilitates social recognition.2015

    • Author(s)
      Takayanagi Y, Yoshida M, Takashima A, Takanami K, Yoshida S, Nishimori K, Nishijima I, Sakamoto H, Yamagata T, Onaka T
    • Journal Title

      Biological Psychiatry

      Volume: in press Issue: 3 Pages: 243-251

    • DOI

      10.1016/j.biopsych.2015.11.021

    • Related Report
      2016 Annual Research Report 2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Osmotic/ionic status of body fluids in the euryhaline cephalopod suggest parallel evolution of osmoregulation2015

    • Author(s)
      Sakamoto et al.
    • Journal Title

      Scientific Reports

      Volume: 5 Issue: 1 Pages: 1-11

    • DOI

      10.1038/srep14469

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] In vivo imaging of mitochondrial axonal transport in the diseased and aged mammalian CNS2015

    • Author(s)
      Takihara et al.
    • Journal Title

      Proceedings of the National Academy of Sciences of the U.S.A.

      Volume: 112 Issue: 33 Pages: 10515-10520

    • DOI

      10.1073/pnas.1509879112

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Three-dimensional visualization of multiple synapses in thick sections using high-voltage electron microscopy in the rat spinal cord2015

    • Author(s)
      Satoh et al.
    • Journal Title

      Data in Brief

      Volume: 4 Pages: 566-570

    • DOI

      10.1016/j.dib.2015.07.005

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Neurohypophysial hormones regulate the amphibious behavior in the mudskipper goby2015

    • Author(s)
      Sakamoto et al.
    • Journal Title

      PLoS ONE

      Volume: 10 Issue: 7 Pages: 1-16

    • DOI

      10.1371/journal.pone.0134605

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effective synaptome analysis of itch-mediating neurons in the spinal cord: a novel immunohistochemical methodology using high-voltage electron microscopy2015

    • Author(s)
      Satoh et al.
    • Journal Title

      Neuroscience Letters

      Volume: 599 Pages: 86-91

    • DOI

      10.1016/j.neulet.2015.05.031

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] In vivo processing and release into the circulation of GFP-fusion protein in arginine vasopressin-enhanced GFP transgenic rats: response to osmotic stimulation2015

    • Author(s)
      Satoh et al.
    • Journal Title

      The FEBS Journal

      Volume: 282 Issue: 13 Pages: 2488-2499

    • DOI

      10.1111/febs.13291

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Oxytocin and the gastrin-releasing peptide system in the spinal cord: Implications for male sexual problems2015

    • Author(s)
      Sakamoto and Oti
    • Journal Title

      Interdisciplinary Information Sciences

      Volume: 21 Pages: 235-242

    • NAID

      110009966532

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Critical role of androgen receptor in the postnatal period in male sexual behavior in rats.2015

    • Author(s)
      Yamada S, Ooya M, Takanami K, Matsuda KI, Kawata M.
    • Journal Title

      Neuroscience Letters

      Volume: 609 Pages: 189-93

    • DOI

      10.1016/j.neulet.2015.10.040

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Structure-function correlations of rat trigeminal primary neurons: Emphasis on club-like endings, a vibrissal mechanoreceptor2015

    • Author(s)
      Tonomura et al.
    • Journal Title

      Proceedings of the Japan Academy, Series B

      Volume: 91 Issue: 10 Pages: 560-576

    • DOI

      10.2183/pjab.91.560

    • NAID

      130005113824

    • ISSN
      0386-2208, 1349-2896
    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Action of TRPA1 agonists on dorsal root-evoked synaptic transmission to substantia gelatinosa neurons in adult rat spinal cord2015

    • Author(s)
      Uta et al.
    • Journal Title

      The Journal of Functional Diagnosis of the Spinal Cord

      Volume: 36 Pages: 5-11

    • NAID

      40020753914

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Inhibitory synaptic transmission from the substantia nigra pars reticulata to the ventral medial thalamus in mice.2015

    • Author(s)
      Kase D, Uta D, Ishihara H and Imoto K.
    • Journal Title

      Neurosci Res.

      Volume: 97 Pages: 26-35

    • DOI

      10.1016/j.neures.2015.03.007

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Pain-enhancing mechanism through interaction between TRPV1 and anoctamin 1 in sensory neurons2015

    • Author(s)
      Takayama Y, Uta D, Furue H, Tominaga M
    • Journal Title

      Proceedings of the National Academy of Sciences of the U S A.

      Volume: 112(16) Issue: 16 Pages: 5213-8

    • DOI

      10.1073/pnas.1421507112

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] ホルモンによる知覚調節-ライフサイクルやストレス応答に着目して-2017

    • Author(s)
      高浪景子
    • Organizer
      奈良女子大学 こころとからだの健康シンポジウム
    • Place of Presentation
      奈良女子大学、奈良
    • Year and Date
      2017-02-22
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 免疫電顕を用いて神経ペプチドの開口分泌を三次元的に捉える試み2016

    • Author(s)
      佐藤慧太、高浪景子、宮崎直幸、宋 致ほん、村田和義、坂本竜哉、坂本浩隆
    • Organizer
      生体ボリュームイメージング研究部会・生理研研究会 合同ワークショップ
    • Place of Presentation
      生理学研究所、岡崎
    • Year and Date
      2016-11-16
    • Related Report
      2016 Annual Research Report
  • [Presentation] Evolution and biological significance of itch2016

    • Author(s)
      Takanami K
    • Organizer
      Joint meeting of the 22nd International Congress of Zoology and the 87th meeting of Zoological Society of Japan
    • Place of Presentation
      Okinawa Convention Center, Ginowan, Okinawa, Japan
    • Year and Date
      2016-11-15
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] GnRH-like peptide in the platyhelminth (flatworm, Stylochoplana pusilla): A possible evolutional origin2016

    • Author(s)
      Hirano M, Yoshida M, Tsutsui N, Kobayashi Y, Hamada M, Sakamoto T, Sakamoto H
    • Organizer
      Joint meeting of the 22nd International Congress of Zoology and the 87th meeting of Zoological Society of Japan
    • Place of Presentation
      Okinawa Convention Center, Ginowan, Okinawa, Japan
    • Year and Date
      2016-11-14
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 免疫電子顕微鏡法による痒みの神経回路網解析2016

    • Author(s)
      高浪景子、佐藤慧太、河田光博、坂本竜哉、坂本浩隆
    • Organizer
      日本解剖学会第71回中国・四国支部学術集会
    • Place of Presentation
      岡山大学鹿田キャンパス、岡山
    • Year and Date
      2016-10-22
    • Related Report
      2016 Annual Research Report
  • [Presentation] 行動を司る時・空間的神経内分泌制御メカニズム2016

    • Author(s)
      坂本浩隆
    • Organizer
      第43回日本神経内分泌学会学術集会
    • Place of Presentation
      アクトシティ浜松、浜松
    • Year and Date
      2016-10-14
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 雄の性機能を司る神経内分泌系の解析2016

    • Author(s)
      坂本浩隆
    • Organizer
      第43回日本神経内分泌学会学術集会
    • Place of Presentation
      アクトシティ浜松、浜松
    • Year and Date
      2016-10-14
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 雄の性機能を司る脊髄神経回路系の機能解析:Grp-promoter-Venusトランスジェニックラットの作出と利用2016

    • Author(s)
      越智拓海、高浪景子、松田賢一、河田光博、坂本竜哉、坂本浩隆
    • Organizer
      第43回日本神経内分泌学会学術集会
    • Place of Presentation
      アクトシティ浜松、浜松
    • Year and Date
      2016-10-14
    • Related Report
      2016 Annual Research Report
  • [Presentation] オキシトシンによるシナプスを介さない雄の性機能制御機構2016

    • Author(s)
      佐藤慧太、越智拓海、高浪景子、坂本竜哉、坂本浩隆
    • Organizer
      第43回日本神経内分泌学会学術集会
    • Place of Presentation
      アクトシティ浜松、浜松
    • Year and Date
      2016-10-14
    • Related Report
      2016 Annual Research Report
  • [Presentation] 系統進化学的アプローチによる痒み感覚の獲得およびその生理機能の統合解明に関する研究2016

    • Author(s)
      高浪景子
    • Organizer
      H28年度RPD研究交流会
    • Place of Presentation
      明治記念館、東京
    • Year and Date
      2016-09-26
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] トランスジェニックラットにおける蛍光タンパク質の生体内動態解析2016

    • Author(s)
      佐藤慧太、越智拓海、上田陽一、John F. Morris、坂本竜哉、坂本浩隆
    • Organizer
      第25回日本行動神経内分泌研究会
    • Place of Presentation
      ホテルサンミ倶楽部、熱海
    • Year and Date
      2016-09-13
    • Related Report
      2016 Annual Research Report
  • [Presentation] ガストリン放出ペプチド受容体を中心とした雄の性行動を司る脳-脊髄神経ネットワークの解析2016

    • Author(s)
      高橋俊次、越智拓海、高浪景子、坂本竜哉、坂本浩隆
    • Organizer
      第25回日本行動神経内分泌研究会
    • Place of Presentation
      ホテルサンミ倶楽部、熱海
    • Year and Date
      2016-09-13
    • Related Report
      2016 Annual Research Report
  • [Presentation] 形態学から迫る”かゆみ”の伝達と進化2016

    • Author(s)
      高浪景子
    • Organizer
      H28年度第1回理工学研究部テニュアトラックセミナー
    • Place of Presentation
      富山大学五福キャンパス理学部、富山
    • Year and Date
      2016-09-07
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 分子・神経内分泌動態の組織細胞化学的可視化2016

    • Author(s)
      坂本浩隆、佐藤慧太、高浪景子
    • Organizer
      第57回日本組織細胞化学会総会・学術集会
    • Place of Presentation
      杏林大学井の頭キャンパス、東京
    • Year and Date
      2016-09-03
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] ラットにおける神経ペプチドホルモンの放出動態を組織化学的に捉える試み2016

    • Author(s)
      佐藤慧太、越智拓海、高浪景子、坂本竜哉、坂本浩隆
    • Organizer
      第57回日本組織細胞化学会 総会・学術集会
    • Place of Presentation
      杏林大学井の頭キャンパス、東京
    • Year and Date
      2016-09-03
    • Related Report
      2016 Annual Research Report
  • [Presentation] ニホンザル脊髄における痒み特異的伝達分子gastrin-releasing peptide受容体の発現2016

    • Author(s)
      伊藤隆志、高浪景子、越智拓海、小林靖尚、佐藤慧太、高橋俊次、上田康雅、坂本竜哉、坂本浩隆
    • Organizer
      第57回日本組織細胞化学会 総会・学術集会
    • Place of Presentation
      杏林大学井の頭キャンパス、東京
    • Year and Date
      2016-09-03
    • Related Report
      2016 Annual Research Report
  • [Presentation] 「基礎系」オキシトシンと性機能2016

    • Author(s)
      坂本浩隆
    • Organizer
      日本性機能学会第27回学術総会/The 11th Japan-ASEAN Conference on Men's Health & Aging合同大会
    • Place of Presentation
      あべのハルカス、大阪
    • Year and Date
      2016-08-25
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Expression and subcellular localization of CD38 in the hypothalamo-neurohypophysial system in rats2016

    • Author(s)
      Sakamoto H, Satoh K, Oti T, Takanami K, Hirakawa H, Sakamoto T
    • Organizer
      The 39th Annual Meeting of the Japan Neuroscience Society(第39回日本神経科学大会)
    • Place of Presentation
      パシフィコ横浜、横浜
    • Year and Date
      2016-07-20
    • Related Report
      2016 Annual Research Report
  • [Presentation] Expression of gastrin-releasing peptide in the trigeminal sensory system in the musk shrew, Suncus murinus2016

    • Author(s)
      Takanami K, Sakamoto H
    • Organizer
      The 39th Annual Meeting of the Japan Neuroscience Society(第39回日本神経科学大会)
    • Place of Presentation
      パシフィコ横浜、横浜
    • Year and Date
      2016-07-20
    • Related Report
      2016 Annual Research Report
  • [Presentation] 形態学解析から考える痒みの伝達機構2016

    • Author(s)
      高浪景子
    • Organizer
      第121回日本解剖学会総会・全国学術集会
    • Place of Presentation
      ビックパレットふくしま、福島
    • Year and Date
      2016-03-28
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] スンクスにおける神経ペプチド・ホルモン分子の進化と機能2016

    • Author(s)
      高浪景子
    • Organizer
      第10回スンクス研究会
    • Place of Presentation
      ビックパレットふくしま、福島
    • Year and Date
      2016-03-27
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] In vivo patch-clamp recording analysis of a pruritogen serotonin-induced itching on synaptic transmission in spinal dorsal horn neurons2016

    • Author(s)
      Daisuke Uta
    • Organizer
      The 89th Annual Meeting of the Japan Pharmacological Society
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-03-09
    • Related Report
      2015 Research-status Report
  • [Presentation] Spinal interleukin-18 contributes to herpetic allodynia through T cell infiltration in mice2016

    • Author(s)
      A. Takatsuki
    • Organizer
      The 89th Annual Meeting of the Japan Pharmacological Society
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-03-09
    • Related Report
      2015 Research-status Report
  • [Presentation] Reactive oxygen species and transient receptor potential ankyrin 1 are involved in dysesthesia induced by a sudden increase of peripheral blood flow in oxaliplatin-treated mice2016

    • Author(s)
      A. Sakai
    • Organizer
      The 89th Annual Meeting of the Japan Pharmacological Society
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-03-09
    • Related Report
      2015 Research-status Report
  • [Presentation] 成熟ラット脊髄膠様質におけるTRPA1及びTRPV1作動薬の作用比較-電気生理学的及び形態学的解析を用いて-2016

    • Author(s)
      歌 大介
    • Organizer
      第37回脊髄機能診断研究会
    • Place of Presentation
      イイノホール&カンファレンスセンター、東京
    • Year and Date
      2016-02-06
    • Related Report
      2015 Research-status Report
  • [Presentation] In vivoパッチクランプ法を用いた脊髄後角における痒み情報伝達機構の解析2015

    • Author(s)
      歌 大介
    • Organizer
      痛み研究会2015「痛みの理解を目指した先端的アプローチ」平成27年度生理研研究会
    • Place of Presentation
      岡崎コンファレンスセンター、愛知
    • Year and Date
      2015-12-17
    • Related Report
      2015 Research-status Report
  • [Presentation] 神経ペプチド・ホルモン分子の進化と機能 行動制御モデルとしてのスンクス2015

    • Author(s)
      坂本浩隆
    • Organizer
      第4回実験動物科学シンポジウム
    • Place of Presentation
      岡山理科大学、岡山
    • Year and Date
      2015-12-11
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] スンクスを用いた脳下垂体神経葉ホルモン・受容体系の解析2015

    • Author(s)
      佐藤慧太
    • Organizer
      第70回岡山実験動物研究会例会
    • Place of Presentation
      岡山理科大学、岡山
    • Year and Date
      2015-12-11
    • Related Report
      2015 Research-status Report
  • [Presentation] 三次元電顕技法を用いて開口分泌を捉える試み2015

    • Author(s)
      佐藤慧太
    • Organizer
      SSSEM研究部会&生理研研究会合同ワークショップ
    • Place of Presentation
      岡崎コンファレンスセンター、愛知
    • Year and Date
      2015-11-18
    • Related Report
      2015 Research-status Report
  • [Presentation] 3-Dimensional visualization of multiple synapses in thick sections using high-voltage electron microscopy in the rat sensory neurons2015

    • Author(s)
      高浪景子
    • Organizer
      SSSEM研究部会&生理研研究会合同ワークショップ
    • Place of Presentation
      岡崎コンファレンスセンター、愛知
    • Year and Date
      2015-11-18
    • Related Report
      2015 Research-status Report
  • [Presentation] 抗がん薬oxaliplatin投与による血流低下状態のマウスにおいて急激な局所血流増加はしびれよう異常感覚を誘発する2015

    • Author(s)
      酒井晶帆
    • Organizer
      日本薬学会北陸支部第127回例会
    • Place of Presentation
      富山大学杉谷キャンパス
    • Year and Date
      2015-11-15
    • Related Report
      2015 Research-status Report
  • [Presentation] 医学・生物学分野における超高圧電子顕微鏡・トモグラフィー法の再考: A revisiting study for 3D-EM2015

    • Author(s)
      坂本浩隆
    • Organizer
      第56回日本組織細胞化学会 総会・学術集会
    • Place of Presentation
      関西医科大学、枚方
    • Year and Date
      2015-10-03
    • Related Report
      2015 Research-status Report
  • [Presentation] ほ乳類三叉神経知覚系の比較組織学解析2015

    • Author(s)
      高浪景子
    • Organizer
      第56回日本組織細胞化学会 総会・学術集会
    • Place of Presentation
      関西医科大学、枚方
    • Year and Date
      2015-10-03
    • Related Report
      2015 Research-status Report
  • [Presentation] AVP-eGFP TgラットにおけるインビボGFP動態2015

    • Author(s)
      佐藤慧太
    • Organizer
      第56回日本組織細胞化学会 総会・学術集会
    • Place of Presentation
      関西医科大学、枚方
    • Year and Date
      2015-10-03
    • Related Report
      2015 Research-status Report
  • [Presentation] 霊長類ニホンザルの脊髄におけるgastrin-releasing peptide系の存在2015

    • Author(s)
      伊藤隆志
    • Organizer
      第56回日本組織細胞化学会 総会・学術集会
    • Place of Presentation
      関西医科大学、枚方
    • Year and Date
      2015-10-03
    • Related Report
      2015 Research-status Report
  • [Presentation] Effective ultrastructure neuroimaging of itch2015

    • Author(s)
      Keiko Takanami
    • Organizer
      The 8th World Congress on Itch
    • Place of Presentation
      Nara Kasugano International Forum IRAKA, Nara, Japan
    • Year and Date
      2015-09-27
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Evaluation of itch by in vivo patch clamp method2015

    • Author(s)
      Daisuke Uta
    • Organizer
      The 8th World Congress on Itch
    • Place of Presentation
      Nara Kasugano International Forum IRAKA, Nara, Japan
    • Year and Date
      2015-09-27
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] In vivo spinal synaptic responses and scratching behaviors evoked by cutaneous 5-HT application2015

    • Author(s)
      Daisuke Uta
    • Organizer
      8th World Congress on Itch
    • Place of Presentation
      Nara Kasugano International Forum IRAKA, Nara, Japan
    • Year and Date
      2015-09-27
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 神経内分泌機構による痒み感覚調節2015

    • Author(s)
      高浪景子
    • Organizer
      第42回日本神経内分泌学会・第23回日本行動神経内分泌学会合同学術集会
    • Place of Presentation
      仙台市戦災復興記念館、仙台
    • Year and Date
      2015-09-18
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 超高圧電子顕微鏡・トモグラフィー法を用いた脊髄内痒み神経ネットワークの解析2015

    • Author(s)
      坂本浩隆
    • Organizer
      第42回日本神経内分泌学会 第23回日本行動神経内分泌学会合同学術集会
    • Place of Presentation
      仙台市戦災復興記念館、仙台
    • Year and Date
      2015-09-18
    • Related Report
      2015 Research-status Report
  • [Presentation] オキシトシンによる雄の性機能制御メカニズムの行動レベルでの解析2015

    • Author(s)
      越智拓海
    • Organizer
      第42回日本神経内分泌学会 第23回日本行動神経内分泌学会合同学術集会
    • Place of Presentation
      仙台市戦災復興記念館、仙台
    • Year and Date
      2015-09-18
    • Related Report
      2015 Research-status Report
  • [Presentation] ガストリン放出ペプチド受容体に着目した雄の性行動を司る脳-脊髄神経ネットワークの解析2015

    • Author(s)
      高橋俊次
    • Organizer
      第42回日本神経内分泌学会 第23回日本行動神経内分泌学会合同学術集会
    • Place of Presentation
      仙台市戦災復興記念館、仙台
    • Year and Date
      2015-09-18
    • Related Report
      2015 Research-status Report
  • [Presentation] ‘Volume transmission’ role for oxytocin projections in the lumbar spinal cord controlling male sexual function2015

    • Author(s)
      Hirotaka Sakamoto
    • Organizer
      Parvo- and Magnocellular Symposium in Sendai 2015
    • Place of Presentation
      Gonryo Kaikan, Sendai, Japan
    • Year and Date
      2015-09-17
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] メダカ脳・生殖腺におけるアンドロゲン受容体α/βそれぞれの発現と分布2015

    • Author(s)
      沖田誠司
    • Organizer
      第86回日本動物学会
    • Place of Presentation
      新潟大学、新潟
    • Year and Date
      2015-09-17
    • Related Report
      2015 Research-status Report
  • [Presentation] 原始左右相称動物・扁形動物ヒラムシにおけるGnRHの同定2015

    • Author(s)
      平野 誠
    • Organizer
      第86回日本動物学会
    • Place of Presentation
      新潟大学、新潟
    • Year and Date
      2015-09-17
    • Related Report
      2015 Research-status Report
  • [Presentation] 魚類および両生類・神経系におけるガストリン放出ペプチド系の同定2015

    • Author(s)
      廣岡あすか
    • Organizer
      第86回日本動物学会
    • Place of Presentation
      新潟大学、新潟
    • Year and Date
      2015-09-17
    • Related Report
      2015 Research-status Report
  • [Presentation] 真骨魚類AR遺伝子の分子進化と雄性形質発現に果たす役割2015

    • Author(s)
      荻野由紀子
    • Organizer
      第86回日本動物学会
    • Place of Presentation
      新潟大学、新潟
    • Year and Date
      2015-09-17
    • Related Report
      2015 Research-status Report
  • [Presentation] Visualization of GRP-containing neurons expressing Venus fluorescence under the control of the GRP promoter: a new rodent model for the analyses of the male sexual function and itch sensation at the spinal cord level2015

    • Author(s)
      越智拓海
    • Organizer
      第38回日本神経科学大会
    • Place of Presentation
      神戸国際会議場、神戸
    • Year and Date
      2015-07-28
    • Related Report
      2015 Research-status Report
  • [Presentation] Firing pattern of substantia gelatinosa neurons receiving TRPA1-expressing afferents in rat spinal cord; in vitro and in vivo patch clamp analysis2015

    • Author(s)
      Daisuke Uta
    • Organizer
      第37回日本疼痛学会
    • Place of Presentation
      市民会館崇城大学ホール、熊本
    • Year and Date
      2015-07-03
    • Related Report
      2015 Research-status Report
  • [Presentation] In vivoパッチクランプ法を用いた痛覚シナプス伝達の解析2015

    • Author(s)
      歌 大介
    • Organizer
      国立長寿医療研究センターCAMDセミナー
    • Place of Presentation
      国立長寿医療研究センター
    • Year and Date
      2015-06-23
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 男性性機能を制御する神経ネットワークと神経ホルモンとの機能連関2015

    • Author(s)
      坂本浩隆
    • Organizer
      第25回日本性機能学会 中部総会
    • Place of Presentation
      ハービスOSAKA、大阪
    • Year and Date
      2015-06-20
    • Related Report
      2015 Research-status Report
  • [Book] 基礎生物科学 第11章「動物における生体制御の仕組み」、第13章「脳と行動の仕組み2016

    • Author(s)
      坂本 浩隆(高橋純夫編)
    • Total Pages
      268
    • Publisher
      培風館
    • Related Report
      2016 Annual Research Report
  • [Book] 基礎生物科学2016

    • Author(s)
      坂本浩隆
    • Publisher
      培風館
    • Related Report
      2015 Research-status Report
  • [Book] Handbook of Hormones: Comparative and General Endocrinology2015

    • Author(s)
      Hirotaka Sakamoto
    • Total Pages
      645
    • Publisher
      Elsevier
    • Related Report
      2015 Research-status Report
  • [Remarks] 岡山大学理学部附属臨海実験所/文部科学省共同利用拠点(UMI)

    • URL

      http://www.science.okayama-u.ac.jp/~rinkai/ushi.htm

    • Related Report
      2016 Annual Research Report
  • [Remarks] 岡山大学 理学部附属牛窓臨海実験所

    • URL

      http://www.science.okayama-u.ac.jp/~rinkai/ushi.htm

    • Related Report
      2015 Research-status Report
  • [Remarks] 富山大学 医学薬学研究部応用薬理学研究室

    • URL

      http://www.pha.u-toyama.ac.jp/phapha2/Japanese/frame.htm

    • Related Report
      2015 Research-status Report

URL: 

Published: 2015-04-16   Modified: 2018-03-22  

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