A new approach for the understand of neural mechanisms underlying the intractable pruritus
| Project/Area Number |
15K15202
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pain science
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| Research Institution | Okayama University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
高浪 景子 岡山大学, 自然科学研究科, 特別研究員(RPD) (70578830)
歌 大介 富山大学, 大学院医学薬学研究部(薬学), 助教 (70598416)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | ガストリン放出ペプチド (GRP) / GRP受容体 / 痒み / 難治性掻痒症 / 霊長類 / 遺伝子改変ラット / 脊髄 / 三叉神経系 / GRＰ受容体 / ガストリン放出ペプチド（GRP） |
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| Outline of Final Research Achievements |
Itch or pruritus has been defined as an unpleasant sensation of the skin that provokes the urge to scratch in order to relieve the stress of itch. Itch followed by scratching worsens skin inflammation, inducing an itch-scratch cycle. Important findings have recently demonstrated that spinal itch transmission is independent of pain transmission and relies on gastrin-releasing peptide (GRP)/GRP receptor signalling in the dorsal horn of the spinal cord, as well as in the trigeminal sensory system in the medulla oblongata. We have recently generated a transgenic rat expressing the red fluorescent protein under control of the GRPR promoter. In this study, we used this transgenic rat model to examine the GRPR system in vivo in rodents. On the other hand, macaque monkeys appear to be an excellent model because they are close primate relatives to humans. Therefore, in this study, we also worked to identify this GRP system in primates using the Japanese macaque monkey (Macaca fuscata).
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Report
(3 results)
Research Products
(76 results)
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[Journal Article] Principal function of mineralocorticoid signaling suggested by constitutive knockout of the mineralocorticoid receptor in medaka fish.2016
Author(s)
Sakamoto, T., Yoshiki, M., Takahashi, H., Yoshida, M., Ogino, Y., Ikeuchi, T., Nakamachi, T., Konno, N., Matsuda, K. and Sakamoto, H.
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Journal Title
Scientific Reports
Volume: -
Issue: 1
Pages: 37991-37991
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] Evolution and biological significance of itch2016
Author(s)
Takanami K
Organizer
Joint meeting of the 22nd International Congress of Zoology and the 87th meeting of Zoological Society of Japan
Place of Presentation
Okinawa Convention Center, Ginowan, Okinawa, Japan
Year and Date
2016-11-15
Related Report
Int'l Joint Research / Invited
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[Presentation] GnRH-like peptide in the platyhelminth (flatworm, Stylochoplana pusilla): A possible evolutional origin2016
Author(s)
Hirano M, Yoshida M, Tsutsui N, Kobayashi Y, Hamada M, Sakamoto T, Sakamoto H
Organizer
Joint meeting of the 22nd International Congress of Zoology and the 87th meeting of Zoological Society of Japan
Place of Presentation
Okinawa Convention Center, Ginowan, Okinawa, Japan
Year and Date
2016-11-14
Related Report
Int'l Joint Research
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