Effect of vitamin D insufficiency on major causes of disability: 10-year follow-up of a population-based cohort

• Project/Area Number: 15K15219
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Epidemiology and preventive medicine
• Research Institution: The University of Tokyo
• Principal Investigator: Yoshimura Noriko 東京大学, 医学部附属病院, 特任教授 (60240355)
• Co-Investigator(Kenkyū-buntansha): 村木 重之 東京大学, 医学部附属病院, 登録研究員 (40401070) ; 岡 敬之 東京大学, 医学部附属病院, 特任准教授 (60401064)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 医療・福祉 / 血清25-hydroxyvitamin D値 / 要介護 / コホート研究 / メタボリックシンドローム / サルコペニア / 骨粗鬆症 / ロコモティブシンドローム / 血清25(OH)D値

Outline of Final Research Achievements

The prospective cohort study entitled ROAD, initiated in 2005-7, aims to clarify epidemiological indices and risk factors for musculoskeletal disorders and to determine their effect on activities of daily living and quality of life in Japanese men and women. The ROAD study collects information on metabolic syndrome components and cognitive assessments. Residents in the same communities were assessed at 3-, 7-, and 10-year follow-up. Serum 25-hydroxyvitamin D (25D) levels averaged 25.1 ng/mL at the 10-year follow-up survey, and were significantly higher than at baseline (p<0.0001). The higher serum 25D levels significantly decreased the risk of osteoporosis at the femoral neck (p<0.05). However, serum 25D levels were not significantly associated with the risk of knee osteoarthritis, sarcopenia, metabolic syndrome components (obesity, hypertension, impaired glucose tolerance, dyslipidaemia), or the presence of mild cognitive impairment.

Research Products

• [Journal Article] Radiographic Knee Osteoarthritis and Knee Pain: Cross-sectional study from Five Different Racial/Ethnic Populations. (2018)
  • Author(s): Wang K, Kim HA, Felson DT, Xu L, Kim DH, Nevitt MC, Yoshimura N, Kawaguchi H, Lin J, Kang X, Zhang Y
  • Journal Title: Sci Rep Volume: 8 Issue: 1 Pages: 1364-1364
  • DOI: 10.1038/s41598-018-19470-3
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Diffuse idiopathic skeletal hyperostosis is associated with lumbar spinal stenosis requiring surgery. (2018)
  • Author(s): Yamada K, Satoh S, Hashizume H, Yoshimura N, Ryohei Kagotani R, Yuyu Ishimoto Y, Abe Y, Toyoda H, Terai H, Masuda T, Muraki S, Nakamura H, Yoshida M
  • Journal Title: J Bone Miner Metab Volume: in press Issue: 1 Pages: 118-124
  • DOI: 10.1007/s00774-017-0901-0
  • NAID: 120006783763
  • Peer Reviewed
• [Journal Article] Harmonising measures of osteoarthritis in population-based cohort studies: an international study. (2018)
  • Author(s): Leyland KM, Gates LS, Nevitt M, Felson D, Bierma-Zeinstra SM, Conaghan PG, Engebretsen L, Hochberg M, Hunter D, Jones G, Jordan JM, Judge A, Lohmander S, Roos EM, Sanchez-Santos MT , Yoshimura N, van Meurs JBJ, Batt ME, Newton J, Cooper C, Arden NK
  • Journal Title: Osteoarthritis Cartilage Volume: in press Issue: 7 Pages: 872-879
  • DOI: 10.1016/j.joca.2018.01.024
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Is osteoporosis a predictor for future sarcopenia, or vice-versa? Four-year observations between the second and third ROAD study surveys. (2017)
  • Author(s): Yoshimura N, Muraki S, Oka H, Iidaka T, Kodama R, Kawaguchi H, Nakamura K, Tanaka S, Akune T:
  • Journal Title: Osteoporos Int Volume: 28 Issue: 1 Pages: 1-7
  • DOI: 10.1007/s00198-016-3823-0
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Association of Lumbar Spondylolisthesis with Low Back Pain and Symptomatic Lumbar Spinal Stenosis in a Population-based Cohort: The Wakayama Spine Study. (2017)
  • Author(s): Ishimoto Y, Yoshimura N, Muraki S, Yamada H, Nagata K, Hashizume H, Takiguchi N, Minamide A, Oka H, Tanaka S, Kawaguchi H, Nakamura K, Akune T, Yoshida M.
  • Journal Title: Spine Volume: 印刷中 Issue: 11 Pages: E666-E671
  • DOI: 10.1097/brs.0000000000001960
  • Peer Reviewed
• [Journal Article] Progression, incidence, and risk factors for intervertebral disc degeneration in a longitudinal population-based cohort: the Wakayama Spine Study. (2017)
  • Author(s): Teraguchi M, Yoshimura N, Hashizume H, Yamada H, Oka H, Minamide A, Nagata K, Ishimoto Y, Kagotani R, Kawaguchi H, Tanaka S, Akune T, Nakamura K, Muraki S, Yoshida M.
  • Journal Title: Osteoarthritis Cartilage Volume: 印刷中 Issue: 7 Pages: 1122-1131
  • DOI: 10.1016/j.joca.2017.01.001
  • NAID: 40021443587
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Quadriceps muscle strength reference value as index for functional deterioration of locomotive organs: Data from 3617 men and women in Japan. (2017)
  • Author(s): Narumi K, Funaki Y, Yoshimura N, Muraki S, Omori G, Nawata A, Seki R
  • Journal Title: J Orthop Sci Volume: 22 Issue: 4 Pages: 765-770
  • DOI: 10.1016/j.jos.2017.03.012
  • Peer Reviewed
• [Journal Article] Sagittal spino-pelvic alignment in adults (2017)
  • Author(s): Asai Y, Tsutsui S, Oka H, Yoshimura N, Hashizume H, Yamada H, Akune T, Muraki S, Matsudaira K, Kawaguchi H, Nakamura K, Tanaka S, Yoshida M.
  • Journal Title: PLoS One Volume: Jun 6;12(6) Issue: 6 Pages: e0178697-e0178697
  • DOI: 10.1371/journal.pone.0178697
  • Peer Reviewed / Open Access
• [Journal Article] MRI-defined paraspinal muscle morphology in Japanese population: The Wakayama Spine Study. (2017)
  • Author(s): Sasaki T, Yoshimura N, Hashizume H, Yamada H, Oka H, Matsudaira K, Iwahashi H, Shinto K, Ishimoto Y, Nagata K, Teraguchi M, Kagotani R, Muraki S, Akune T, Tanaka S, Kawaguchi H, Nakamura K, Minamide A, Nakagawa Y, Yoshida M.
  • Journal Title: PLoS One Volume: 12 Issue: 11 Pages: e0187765-e0187765
  • DOI: 10.1371/journal.pone.0187765
  • Peer Reviewed / Open Access
• [Journal Article] Epidemiological differences between localised and non-localised low back pain. (2017)
  • Author(s): Coggon D, Ntani G, Walker-Bone K, Yoshimura N, et al
  • Journal Title: Spine (Phila Pa 1976), 740-747, 2017 Volume: 42 Issue: 10 Pages: 740-747
  • DOI: 10.1097/brs.0000000000001956
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] The prevalence of tandem spinal stenosis and its characteristics in a population-based MRI study: The Wakayama Spine Study (2017)
  • Author(s): Nagata K, Yoshimura N, Hashizume H, Ishimoto Y, Muraki S, Yamada H, Oka H, Kawaguchi H, Akune T, Tanaka S, Nakamura K, Yoshida M
  • Journal Title: Eur Spine J Volume: in press Issue: 10 Pages: 2529-2535
  • DOI: 10.1007/s00586-017-5072-0
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Radiographic measurements of the hip joint and their associations with hip pain in Japanese men and women: the Research on Osteoarthritis/osteoporosis Against Disability (ROAD) study. (2017)
  • Author(s): Iidaka T, Muraki S, Oka H, Kodama R, Tanaka S, Kawacughi H, Nakamura K, Akune T, Yoshimura N
  • Journal Title: Osteoarthritis Cartilage Volume: 25 Issue: 12 Pages: 2072-2079
  • DOI: 10.1016/j.joca.2017.08.008
  • Peer Reviewed / Open Access
• [Journal Article] Artificial neural networks to predict future bone mineral density and bone loss rate in Japanese menopausal women. (2017)
  • Author(s): Shioji M, Yamamoto T, Ibata T, Tsuda T, Adachi K, Yoshimura N
  • Journal Title: BMC Research Notes Volume: 10 Issue: 1 Pages: 590-590
  • DOI: 10.1186/s13104-017-2910-4
  • Peer Reviewed
• [Journal Article] Serum Levels of Matrix Metalloproteinase-3 and Autoantibodies Related to 2 Rheumatoid Arthritis in the General Japanese Population and their Association with Osteoporosis and Osteoarthritis: The ROAD Study (2017)
  • Author(s): Kodama R, Muraki S, Iidaka T, Oka H, Teraguhi M, Kagotani R, Asai Y, Hashizume H, Yoshida M, Kawaguchi H, Nakamura K, Akune T, Tanaka S, Yoshimura N.
  • Journal Title: J Bone Miner Metab Volume: in press Issue: 2 Pages: 246-253
  • DOI: 10.1007/s00774-017-0834-7
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Epidemiology of the locomotive syndrome: The research on osteoarthritis/osteoporosis against disability study 2005-2015 (2017)
  • Author(s): Yoshimura N, Muraki S, Nakamura K, Tanaka S
  • Journal Title: Mod Rheumatol Volume: 27 Pages: 1-7
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Progression, incidence, and risk factors for intervertebral disc degeneration in a longitudinal population-based cohort: the Wakayama Spine Study (2017)
  • Author(s): Teraguchi M, Yoshimura N, Hashizume H, Yamada H, Oka H, Minamide A, Nagata K, Ishimoto Y, Kagotani R, Kawaguchi H, Tanaka S, Akune T, Nakamura K, Muraki S, Yoshida M
  • Journal Title: Osteoarthritis Cartilage Volume: in press
  • Peer Reviewed / Open Access
• [Journal Article] Metabolic Syndrome Components Are Associated with Intervertebral Disc Degeneration: The Wakayama Spine Study. (2016)
  • Author(s): Teraguchi M, Yoshimura N, Hashizume H, Muraki S, Yamada H, Oka H, Minamide A, Ishimoto Y, Nagata K, Kagotani R, Tanaka S, Kawaguchi H, Nakamura K, Akune T, Yoshida M.
  • Journal Title: PLoS One Volume: 11 Issue: 2 Pages: e0147565-e0147565
  • DOI: 10.1371/journal.pone.0147565
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Prevalence of radiographic hip osteoarthritis and its association with hip pain in Japanese men and women: The ROAD study. (2016)
  • Author(s): Iidaka T, Muraki S, Akune T, Oka H, Kodama R, Tanaka S, Kawaguchi H, Nakamura K, Yoshimura N
  • Journal Title: Osteoarthritis Cartilage Volume: 24 Issue: 1 Pages: 117-123
  • DOI: 10.1016/j.joca.2015.07.017
  • Peer Reviewed
• [Journal Article] Serum levels of 25-hydroxyvitamin D and occurrence of musculoskeletal diseases, such as osteoporosis, knee osteoarthritis and lumbar spondylosis: A three-year follow-up of the road study. (2015)
  • Author(s): Yoshimura N, Muraki S, Oka H, Nakamura K, Kawaguchi H, Tanaka S, Akune T
  • Journal Title: Osteoporos Int Volume: 26 Issue: 1 Pages: 151-161
  • DOI: 10.1007/s00198-014-2844-9
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Association between new indices in the locomotive syndrome risk test and decline in mobility: third survey of the ROAD study. (2015)
  • Author(s): Yoshimura N, Musaki S, Oka H, Tanaka S, Ogata T, Kawaguchi H, Akune T, Nakamura K
  • Journal Title: J Orthop Sci Volume: 20 Issue: 5 Pages: 896-905
  • DOI: 10.1007/s00776-015-0741-5
  • Peer Reviewed / Open Access
• [Journal Article] Urinary 8-iso-prostaglandin F2a as a marker of metabolic risks in the general Japanese population: The ROAD study. (2015)
  • Author(s): Mure K, Yoshimura N, Hashimoto M, Muraki S, Oka H, Tanaka S, Kawaguchi H, Nakamura K, Akune T, Takeshita T
  • Journal Title: Obesity 23:1517-1524, 2015. Volume: 23 Issue: 7 Pages: 1517-1524
  • DOI: 10.1002/oby.21130
  • Peer Reviewed
• [Journal Article] Joint space narrowing, body mass index and knee pain: The ROAD study. (2015)
  • Author(s): Muraki S, Akune T, En-yo Y, Yoshida M, Suzuki T, Yoshida H, Ishibashi H, Tokimura F, Yamamoto S, Tanaka S, Nakamura K, Kawaguchi H, Oka H, Yoshimura N
  • Journal Title: Osteoarthritis Cartilage Volume: 23 Issue: 6 Pages: 874-881
  • DOI: 10.1016/j.joca.2015.01.011
  • Peer Reviewed
• [Presentation] Mutual associations among frailty, sarcopenia and osteoporosis: Four-year observations between the second and third ROAD study surveys. (2018)
  • Author(s): Yoshimura N, Muraki M, Oka H, Iidaka T, Kodama R, Horii C, Kawaguchi H, Nakamura K, Akune T, Tanaka S
  • Organizer: International Conference on Farality & Sarcopenia Research (ICFSR 2018), Miami Beach, USA
  • Int'l Joint Research
• [Presentation] Frailty, sarcopenia, and osteoporosis. The ROAD study (2017)
  • Author(s): Yoshimura N, Muraki S, Oka H, Iidaka T, Kodama R, Kawaguchi H, Nakamura K, Akune T, Tanaka S
  • Organizer: WCO-IOF-ESCEO 2017
  • Place of Presentation: Florence, Italy
  • Year and Date: 2017-03-23
  • Int'l Joint Research
• [Presentation] Mutual associations among frailty, sarcopenia, and osteoporosis. (2017)
  • Author(s): Yoshimura N, Tanaka S, Nakamura K
  • Organizer: World Congress of Epidemiology (WCE) 2017, Saitama
  • Int'l Joint Research / Invited
• [Presentation] Does sarcopenia and osteoporosis increase the risk of occurrence of fraility? Four-year observations between the second and third ROAD study surveys. (2017)
  • Author(s): Yoshimura N, Muraki S, Oka H, Iidaka T, Kodama R, Kawaguchi H, Nakamura K, Akune T, Tanaka S
  • Organizer: Annual Meeting of the American Society for Bone and Mineral Research (ASBMR) 2017, Denver, Colorado, USA
  • Int'l Joint Research
• [Presentation] Epidemiology of the locomotive syndrome: 2017 update (2017)
  • Author(s): Yoshimura N, Nakamura K, Tanaka S
  • Organizer: JCR 2017 Scientific meeting, Fukuoka
  • Int'l Joint Research / Invited
• [Presentation] Epidemiology of the locomotive syndrome: The research on osteoarthritis/osteoporosis against disability (ROAD) study. (2017)
  • Author(s): Yoshimura N, Tanaka S
  • Organizer: 19th Asia Pacific League of Associations for Rheumatology Congress (APLAR 2017), Dubai, UAE
  • Int'l Joint Research / Invited
• [Presentation] 一般住民におけるRA関連血清マーカーの陽性率および骨粗鬆症、変形性関節症との関連―The ROAD study― (2017)
  • Author(s): 児玉理恵、村木重之、飯高世子、田中栄、岡敬之、川口浩、中村耕三、阿久根徹、吉村典子
  • Organizer: 第90回日本整形外科学会学術総会 仙台市
• [Presentation] ロコモティブシンドローム予防の立場から (2017)
  • Author(s): 吉村典子
  • Organizer: 第30回日本老年学会総会 名古屋市
  • Invited
• [Presentation] 寛骨臼形成不全の疫学：有病率と股関節痛との関連 (2017)
  • Author(s): 飯高世子、村木重之、岡敬之、児玉理恵、田中栄、川口浩、中村耕三、阿久根徹、吉村典子
  • Organizer: 第35回日本骨代謝学会学術集会 福岡
• [Presentation] 運動器疾患の性差：地域住民コホートROADより (2017)
  • Author(s): 吉村典子、村木重之、飯高世子、田中栄
  • Organizer: 第17回日本Men’s Health医学会 東京
• [Presentation] 変形性股関節症と職業活動との関連 (2017)
  • Author(s): 飯高世子、村木重之、岡敬之、堀井千彬、田中栄、川口浩、中村耕三、阿久根徹、吉村典子
  • Organizer: 第19回日本骨粗鬆症学会 大阪市
• [Presentation] 25水酸化ビタミンD (2017)
  • Author(s): 吉村典子
  • Organizer: 第19回日本骨粗鬆症学会 大阪市
  • Invited
• [Presentation] ロコモ度テストを用いたロコモティブシンドロームの有病率: The ROAD study (2017)
  • Author(s): 吉村典子、堀井千彬、飯高世子
  • Organizer: 第76回日本公衆衛生学会総会 鹿児島市
• [Presentation] 変形性股関節症の疫学：有病率と痛みとの関連 -The ROAD study- (2017)
  • Author(s): 飯高世子、堀井千彬、吉村典子
  • Organizer: 第76回日本公衆衛生学会総会 鹿児島市
• [Presentation] サルコペニア、フレイルと骨粗鬆症の相互関係 (2016)
  • Author(s): 吉村典子
  • Organizer: 第3回日本サルコペニアレイル学会(シンポジウム）
  • Place of Presentation: 名古屋市
  • Year and Date: 2016-11-06
  • Invited
• [Presentation] サルコペニアと骨粗鬆症：有病率、発生率、相互関係 (2016)
  • Author(s): 吉村典子、村木重之
  • Organizer: 第18回日本骨粗鬆症学会(シンポジウム）
  • Place of Presentation: 仙台市
  • Year and Date: 2016-10-17
  • Invited
• [Presentation] Osteoporosis, not osteoarthritis, could predict the occurrence of sarcopenia in the near future: A 4-year follow-up of the ROAD study (2016)
  • Author(s): Yoshimura N, Muraki S, Oka H, Tanaka S, Kawaguchi, Nakamura K, Akune T
  • Organizer: The European League Against Rheumatism
  • Place of Presentation: London, UK
  • Year and Date: 2016-06-08
  • Int'l Joint Research
• [Presentation] Threshold of joint space width for knee pain: The ROAD study (2016)
  • Author(s): Muraki S, Akune T, Oka H, Tanaka S, Kawaguchi H, Nakamura K, Yoshimura N
  • Organizer: The European League Against Rheumatism
  • Place of Presentation: London, UK
  • Year and Date: 2016-06-08
  • Int'l Joint Research
• [Presentation] Sarcopenia &#8211; prevalence, incidence, and association with osteoporosis: A four-year follow-up of the ROAD study. (2015)
  • Author(s): Yoshimura N, Muraki S, Oka H, Tanaka S, Kawaguchi H, Nakamura K, Akune T
  • Organizer: 37th Annual Meeting of the American Society for Bone and Mineral Research (ASBMR)
  • Place of Presentation: Seattle, USA
  • Year and Date: 2015-10-09
  • Int'l Joint Research
• [Presentation] Sarcopenia is independently associated with knee pain: The ROAD study (2015)
  • Author(s): Muraki S, Akune T, Oka H, Tanaka S, Kawaguchi H, Nakamura K, Yoshimura N
  • Organizer: 37th Annual Meeting of the American Society for Bone and Mineral Research (ASBMR)
  • Place of Presentation: Seattle, USA
  • Year and Date: 2015-10-09
  • Int'l Joint Research
• [Presentation] 25水酸化ビタミンDと骨粗鬆症：ROAD studyから． (2015)
  • Author(s): 吉村典子、村木重之、岡敬之、田中栄、川口浩、中村耕三、阿久根徹
  • Organizer: 第17回日本骨粗鬆症学会
  • Place of Presentation: 広島国際会議場(広島県・広島市)
  • Year and Date: 2015-09-17
  • Invited
• [Presentation] Prognosis of vitamin D insufficiency: A 3-year follow-up of the ROAD study (2015)
  • Author(s): Yoshimura N, Muraki S, Oka H, Tanaka S, Kawaguchi H, Nakamura K, Akune T
  • Organizer: The European League Against Rheumatism (EULAR)
  • Place of Presentation: Rome, Italy
  • Year and Date: 2015-06-10
  • Int'l Joint Research
• [Presentation] Knee symptoms are more strongly associated with quadriceps muscle strength than grip strength or muscle mass. (2015)
  • Author(s): Muraki S, Akune T, Oka H, Tanaka S, Kawaguchi H, Nakamura K, Yoshimura N
  • Organizer: The European League Against Rheumatism (EULAR)
  • Place of Presentation: Rome, Italy
  • Year and Date: 2015-06-10
  • Int'l Joint Research
• [Book] 最新医学別冊診断と治療のABC 変形性関節症 変形性関節症の疫学 (2017)
  • Author(s): 田中栄、吉村典子他
  • Total Pages: 240
  • Publisher: 最新医学社
• [Book] コホート研究から観た運動器障害．ロコモティブシンドローム (2017)
  • Author(s): 吉村典子
  • Publisher: メディカルレビュー社
• [Book] 変形性関節症．総論、疫学．リウマチ病学テキスト改訂第2版 (2016)
  • Author(s): 吉村典子、中村耕三
  • Total Pages: 4
  • Publisher: 診断と治療社
• [Book] 骨粗鬆症の疫学．リウマチ病学テキスト改訂第2版 (2016)
  • Author(s): 吉村典子
  • Total Pages: 3
  • Publisher: 診断と治療社
• [Book] インフォームドコンセントのための図説シリーズ 骨粗鬆症改訂3版（杉本利嗣編） (2015)
  • Author(s): 吉村典子
  • Total Pages: 83
  • Publisher: 医薬ジャーナル社
• [Book] 骨ペディア. 骨疾患・骨代謝キーワード事典(日本骨代謝学会) (2015)
  • Author(s): 吉村典子
  • Total Pages: 328
  • Publisher: 羊土社
• [Book] 骨粗鬆症の予防と治療ガイドライン2015年版（骨粗鬆症の予防と治療ガイドライン作成委員会（代表 折茂肇）編） (2015)
  • Author(s): 吉村典子
  • Total Pages: 208
  • Publisher: ライフサイエンス出版