Evaluation of fetal environmental risk by Mendel randomization analysis and gene-environment interactions
Project/Area Number |
15K15220
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Epidemiology and preventive medicine
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Research Institution | Chuo University (2016-2017) Tokyo Medical and Dental University (2015) |
Principal Investigator |
Sata Fumihiro 中央大学, 保健センター, 医療管理者(常勤嘱託医師) (90187154)
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Co-Investigator(Kenkyū-buntansha) |
岸 玲子 北海道大学, 環境健康科学研究教育センター, センター特別招へい教授 (80112449)
荒木 敦子 北海道大学, 環境健康科学研究教育センター, 准教授 (00619885)
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Co-Investigator(Renkei-kenkyūsha) |
NONOMURA Katsuya 北海道大学, 名誉教授 (60113750)
MITSUI Takahiko 山梨大学, 総合研究部, 准教授 (90421966)
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Research Collaborator |
KOBAYASHI Sumitaka 北海道大学, 環境健康科学研究教育センター, 特任講師 (10733371)
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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Keywords | DOHaD / 出生時体重 / 発育 / 喫煙 / PCB / ダイオキシン類 / 遺伝‐環境交互作用 / メンデル無作為化解析 / 環境疫学 / DOHaD学説 / 胎児期リスク評価 / 遺伝・環境交互作用 |
Outline of Final Research Achievements |
I have published original articles in academic journals and presented at academic meetings on the topic of effects of gene-environment interactions on birth weight, head circumference, and Kaup indices with respect to maternal active and passive smoking, caffeine intake, exposure to polychlorinated biphenyls and dioxins during pregnancy, and genetic polymorphisms of genes encoding metabolic and DNA repair enzymes and receptors. I have also reviewed a series of epidemiological studies related to the concept of the developmental origins of health and disease (DOHaD), especially recent large-scale genome-based birth cohort studies such as genome-wide association studies and epigenome-wide association studies, including Mendelian randomization studies. In addition, I have started a research group called DOHaD Seminar of Epidemiology to emphasize on educational activities based on the DOHaD concept.
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Report
(4 results)
Research Products
(96 results)
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[Journal Article] Effects of prenatal perfluoroalkyl acid exposure on cord blood IGF2/H19 methylation and ponderal index: The Hokkaido Study.2017
Author(s)
Kobayashi S, Azumi K, Goudarzi H, Araki A, Miyashita C, Kobayashi S, Itoh S, Sasaki S, Ishizuka M, Nakazawa H, Ikeno T, Kishi R.
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Journal Title
J Expo Sci Environ Epidemiol
Volume: 27
Issue: 3
Pages: 251-259
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Prenatal di(2-ethylhexyl) phthalate exposure and disruption of adrenal androgens and glucocorticoids levels in cord blood: The Hokkaido Study2017
Author(s)
Araki A., Mitsui T., Goudarzi H., Nakajima T., Miyashita C., Itoh S., Sasaki S., Cho K., Moriya K., Shinohara N., Nonomura K., Kishi R.
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Journal Title
Science of the Total Environment
Volume: 581-582
Pages: 297-304
DOI
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Evaluation of the Japanese Metabolic syndrome risk score (JAMRISK): a newly developed questionnaire used as a screening tool for diagnosing and insulin resistance in Japan2016
Author(s)
C.Tan, Y.Sasagawa, K.Kamo, T.Kukitsu, S.Noda, K.Ishikawa, N.Yamauchi, T.Saikawa, T.Noro, H.Nakamura, F.Takahashi, F.Sata, M.Tada, Y.Kokai
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Journal Title
Environmental Health and Preventive Medicine
Volume: 21 (6)
Issue: 6
Pages: 470-479
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Exposure to phthalates in house dust and associated allergies in children aged 6-12years2016
Author(s)
Ait Bamai, Y., Araki, A., Kawai, T., Tsuboi, T., Saito, I., Yoshioka, E., Cong, S., Kishi, R.
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Journal Title
Environ Int
Volume: 96
Pages: 16-23
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Combined effects of AHR, CYP1A1, and XRCC1 genotypes and prenatal maternal smoking on infant birth size: Biomarker assessment in the Hokkaido Study.2016
Author(s)
Kobayashi S, Sata F, Sasaki S, Braimoh TS, Araki A, Miyashita C, Goudarzi H, Kobayashi S, Kishi R.
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Journal Title
Reprod Toxicol
Volume: 65
Pages: 295-306
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Association of perfluoroalkyl substances exposure in utero with reproductive hormone levels in cord blood in the Hokkaido Study on Environment and Children's Health.2016
Author(s)
Itoh S, Araki A, Mitsui T, Miyashita C, Goudarzi H, Sasaki S, Cho K, Nakazawa H, Iwasaki Y, Shinohara N, Nonomura K, Kishi R.
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Journal Title
Environ Int
Volume: 94
Pages: 51-59
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Effects of adrenal androgens during the prenatal period on the second to fourth digit ratio in school-aged children2016
Author(s)
Mitsui T., Araki A., Goudarzi H., Miyashita C., Ito S., Sasaki S., Kitta T., Moriya K., Cho K., Morioka K., Kishi R., Shinohara N., Takeda M., Nonomura K.
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Journal Title
Steroids
Volume: 113
Pages: 46-51
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] The Association between Prenatal Yoga and the Administration of Ritodrine Hydrochloride during Pregnancy: An Adjunct Study of the Japan Environment and Children's Study.2016
Author(s)
Kawanishi Y, Saijo Y, Yoshioka E, Nakagi Y, Yoshida T, Miyamoto T, Sengoku K, Ito Y, Miyashita C, Araki A, Kishi R.
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Journal Title
PLoS One
Volume: 11
Issue: 6
Pages: e0158155-e0158155
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Predictors of folate status among pregnant Japanese women: the Hokkaido Study on Environment and Children's Health, 2002-2012.2016
Author(s)
Yila TA, Araki A, Sasaki S, Miyashita C, Itoh K, Ikeno T, Yoshioka E, Kobayashi S, Goudarzi H, Baba T, Braimoh T, Minakami H, Endo T, Sengoku K, Kishi R.
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Journal Title
Br J Nutr
Volume: 115
Issue: 12
Pages: 2227-2235
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] The Relationship between the Second-to-Fourth Digit Ratio and Behavioral Sexual Dimorphism in School-Aged Children.2016
Author(s)
Mitsui T, Araki A, Miyashita C, Ito S, Ikeno T, Sasaki S, Kitta T, Moriya K, Cho K, Morioka K, Kishi R, Shinohara N, Takeda M, Nonomura K.
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Journal Title
PLoS One.
Volume: 11(1)
Issue: 1
Pages: e0146849-e0146849
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Associations of Perfluoroalkyl Substances (PFASs) with Lower Birth Weight: An Evaluation of Potential Confounding by Glomerular Filtration Rate Using a Physiologically Based Pharmacokinetic Model (PBPK).2015
Author(s)
M. A. Verner, A. E. Loccisano, N. H. Morken, M. Yoon, H. Wu, R. McDougall, M. Maisonet, M. Marcus, R. Kishi, C. Miyashita, M. H. Chen, W. S. Hsieh, M. E. Andersen, H. J. Clewell, 3rd and M. P. Longnecker.
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Journal Title
Environ Health Perspect
Volume: 123
Issue: 12
Pages: 1317-1317
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Effects of in utero exposure to polychlorinated biphenyls, methylmercury, and polyunsaturated fatty acids on birth size.2015
Author(s)
C. Miyashita, S. Sasaki, T. Ikeno, A. Araki, S. Ito, J. Kajiwara, T. Todaka, N. Hachiya, A. Yasutake, K. Murata, T. Nakajima and R. Kishi.
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Journal Title
Sci Total Environ
Volume: 533
Pages: 256-265
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] The Association of Prenatal Exposure to Perfluorinated Chemicals with Maternal Fatty Acids during Pregnancy and the Birth Weight of their Offspring:The Hokkaido Study2015
Author(s)
Reiko Kishi, Tamie Nakajima, Houman Goudarzi, Sachiko Kobayashi, Seiko Sasaki, Emiko Okada, Chihiro Miyashita, Sachiko Itoh, Atsuko Araki, Tamiko Ikeno, Yusuke Iwasaki, and Hiroyuki Nakazawa
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Journal Title
Environmental Health Perspective
Volume: 印刷中
Issue: 10
Pages: 1038-1045
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Prenatal maternal blood triglyceride and fatty acid levels in relation to exposure to di(2-ethylhexyl)phthalate: a cross-sectional study.2015
Author(s)
Jia X, Harada Y, Tagawa M, Naito H, Hayashi Y, Yetti H, Kato M, Sasaki S, Araki A, Miyashita C, Ikeno T, Kishi R, Nakajima T.
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Journal Title
Environ Health Prev Med.
Volume: In press
Issue: 3
Pages: 168-178
DOI
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] .Prenatal exposure to organochlorine pesticides and steroid hormones profiles in fetal blood-the Hokkaido Study.2016
Author(s)
Atsuko Araki, Chihiro Miyashita, Takahiko Mitsui, Houman Goudarzi, Sachiko Itoh, Futoshi Mizutani, Youichi Chisaki, Seiko Sasaki, Kimihiko Moriya, Kazutoshi Cho, Nobuo Shinohara, Katsuya Nonomura, Reiko Kishi.
Organizer
pptoxV
Place of Presentation
Kitakyusyu, Japan
Year and Date
2016-11-13
Related Report
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[Presentation] Prenatal exposure to organochlorine pesticides and reproductive hormones in fetal blood: The Hokkaido Study. ISEE 2016. Roma, Italy. (2016.9.1-9.4)2016
Author(s)
Atsuko Araki, Chihiro Miyashita, Sachiko Itoh, Takahiko Mitsui, Futoshi Mizutani,Yoichi Chisaki, Seiko Sasaki, Kazutoshi Cho, Katsuya Nonomura, Reiko Kishi.
Organizer
28th Annual Conference International Society for Environmental Epidemiology (ISEE2016)
Place of Presentation
Roma, Italy
Year and Date
2016-09-01
Related Report
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[Presentation] Epigenome-wide analyses of prenatal perfluoroalkyl acids exposure on cord blood DNA methylation: the Hokkaido study.2016
Author(s)
Kobayashi, S., R. Miura, C. Miyashita, A. Araki, M. Ishizuka, H. Nakazawa, Y. Ito, T. Kubota, R. Kishi.
Organizer
28th Annual Conference International Society for Environmental Epidemiology (ISEE2016)
Place of Presentation
Roma, Italy
Year and Date
2016-09-01
Related Report
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[Presentation] Effects of prenatal exposure to perfluoroalkyl acids on risk of allergic and infections diseases in early life.2016
Author(s)
Goudarzi, H., C. Miyashita, E. Okada, I. Kashino, S. Kobayashi, C.-J. Chen, S. Ito, A. Araki, H. Matsuura, R. Kishi.,
Organizer
28th Annual Conference International Society for Environmental Epidemiology (ISEE2016)
Place of Presentation
Roma, Italy
Year and Date
2016-09-01
Related Report
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[Presentation] Hokkaido Study on Environment and Children’s Health: Endocrine Disruption Effect of Perfluoroalkyl Substances Exposure in Utero.2016
Author(s)
Itoh, S., A. Araki, C. Miyashita, H. Goudarzi, S. Kato, Y. Iwasaki, H. Nakazawa, N. Shinohara, R. Kishi.
Organizer
ISEE-ISES AC2016
Place of Presentation
Sapporo, Japan
Year and Date
2016-06-26
Related Report
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[Presentation] Prenatal environment and child behavioral and coordination development at preschool age in the Hokkaido Study.2016
Author(s)
Minatoya, M., N. Tamura, S. Itoh, S. Suyama, C. Miyashita, A. Araki, T. Saito, A. Nakai, R. Kishi.
Organizer
ISEE-ISES AC2016
Place of Presentation
Sapporo, Japan
Year and Date
2016-06-26
Related Report
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[Presentation] Combined Effects on AHR, CYP1A1 and XRCC1 Genetic Polymorphisms and Prenatal Maternal Smoking on Infant Birth Size: The Hokkaido Study on Environment and Children’s Health.2016
Author(s)
Kobayashi, S., F. Sata, S. Sasaki, T. S. Braimoh, A. Araki, C. Miyashita, H. Goudarzi, S. kobayashi, R. Kishi.
Organizer
ISEE-ISES AC2016
Place of Presentation
Sapporo, Japan
Year and Date
2016-06-26
Related Report
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[Presentation] Epigenome-wide Pathway Analyses of Prenatal Perfluoroalkyl Acids Exposure on Cord Blood DNA Methylation: The Hokkaido Study.2016
Author(s)
Kobayashi, S., R. Miura, C. Miyashita, A. Araki, M. Ishizuka, H. Nakazawa, Y. M. Ito, T. Kubota, R. Kishi.
Organizer
ISEE-ISES AC2016
Place of Presentation
Sapporo, Japan
Year and Date
2016-06-26
Related Report
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[Presentation] Effects of maternal AHR, CYP1A1 and GSTM1 polymorphisms and dioxins on infant birth weight: The Hokkaido Study.2015
Author(s)
Kobayashi S, Miyashita C, Sasaki S, Araki A, Sata F, Ban S, Kajiwara J, Todaka T and Kishi R.
Organizer
27th Annual International Society for Environmental Epidemiology Conference (ISEE 2015)
Place of Presentation
Reboucas Conference Center, Sao Paulo, Brazil
Year and Date
2015-08-30
Related Report
Int'l Joint Research
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[Presentation] 胎児期ビスフェノールA曝露影響に関する臍帯血DNA網羅的メチル化解析; 北海道スタディ.2015
Author(s)
小林祥子, 三浦りゅう, 川口章夫, 宮下ちひろ, 三宅邦夫, 松村徹, 山本潤, 石塚真由美, 荒木敦子, 久保田健夫 , 岸玲子.
Organizer
第4回日本DOHaD研究学術集会
Place of Presentation
昭和大学(東京都・品川区)
Year and Date
2015-08-01
Related Report
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