A preliminary study on estimation of dietary acrylamide intake and assessment of its health effects

• Project/Area Number: 15K15222
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Epidemiology and preventive medicine
• Research Institution: Gifu University
• Principal Investigator: Nagata Chisato 岐阜大学, 大学院医学系研究科, 教授 (30283295)
• Co-Investigator(Kenkyū-buntansha): 安藤 京子 愛知文教女子短期大学, 生活文化学科, 教授 (10369572)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 栄養学 / ホルモン / 食品 / 社会医学 / 癌 / 環境

Outline of Final Research Achievements

Acrylamide is formed when foods high in carbohydrates and low in proteins are cooked at a high temperature. Rodents exposed to acrylamide have shown impaired development and reproductive toxicity. Using food content data for acrylamide, dietary acrylamide intake was estimated among 428 preschool children and 392 pregnant women. The study also assessed the associations between acrylamide intake and sex hormone levels among these subjects. The estimates were 21.0μg/d in preschool children and 19.6μg/d in pregnant women. Acrylamide intake was significantly positively associated with urinary levels of testosterone and androst-5-ene-3-beta, 17 beta diol in boys. A higher intake of acrylamide was significantly positively associated with higher levels of testosterone at the 10th week in women with female fetuses and umbilical cord estradiol at the delivery of female babies.

Research Products

• [Journal Article] Acrylamide Intake with Urinary Sex Hormone Levels among Preschool Japanese Children (2017)
  • Author(s): Chisato Nagata, Kie Konishi, Keiko Wada, Takashi Tamura, Yuko Goto, Sachi Koda, Fumi Mizuta, Sakiko Nishizawa, Etsuko Sukigara, Kaori Watanabe, Kyoko Ando.
  • Journal Title: Am J Epidemiol Volume: 印刷中
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Presentation] Cancer Research in the Post-Genome Era: Perspectives from Epidemiology：exposure assessment: consideration and future issue (2015)
  • Author(s): 永田知里
  • Organizer: 第74回日本癌学会
  • Place of Presentation: 名古屋
  • Year and Date: 2015-10-08
• [Remarks] 岐阜大学大学院医学系研究科 疫学・予防医学分野HP Research
  • URL: http://www1.gifu-u.ac.jp/~ph/research.html