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HPV self sampling: A novel method to increase cervical screening uptake

Research Project

Project/Area Number 15K15230
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Hygiene and public health
Research InstitutionHokkaido University

Principal Investigator

Sakuragi Noriaki  北海道大学, 医学研究科, 特任教授 (70153963)

Co-Investigator(Kenkyū-buntansha) Hanley Sharon  北海道大学, 医学研究科, 特任講師 (80529412)
Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywords子宮頸がん / 検診 / 自己採取HPV検査 / 検診受診率向上 / 検診システムの構築 / 自己採取HPV検査
Outline of Final Research Achievements

We investigated barriers to cervical screening and whether HPV self-sampling(SS) might improve screening uptake in non-responders. In adjusted analyses: not in relationship (OR 3.40, 95% CI 1.52-7.59), lower education (OR 1.88, 95% CI 1.04-3.39), smoking (OR 4.06, 95% CI 1.61-10.26), and no perceived risk (OR 3.79, 95% CI 1.43-10.07) were predictors of screening status in under-screened women. For never-screened, it was smoking (OR 5.15, 95% CI 1.93-13.76) and no perceived risk (OR 3.17, 95% CI 1.10-9.14). Common barriers such as 'embarrassment’ and ‘too busy with work/childcare’ were also endorsed by women up-to-date for screening and not predictive of screening status. SS acceptability was high with >90% saying they would use it again and recommend it to friends/family. In the RCT compared to the control, screening uptake in the SS group was significantly higher (RR 8.31, 95% CI:6.68-10.34). SS might be an effective means of improving screening uptake in Japanese women.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • Research Products

    (11 results)

All 2017 2016 2015

All Presentation (11 results) (of which Int'l Joint Research: 5 results,  Invited: 5 results)

  • [Presentation] Smoking and perceived risk and not embarrassment or work/childcare contraints are predictors of being overdue for screening in Japanese women2017

    • Author(s)
      Sharon J. B. Hanley
    • Organizer
      31st International Papillomavirus Conference
    • Place of Presentation
      Cape Town, South Africa
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Smoking status is a predcitor of cervical cancer screening attendance in Japanese women2017

    • Author(s)
      Sharon J. B. Hanley
    • Organizer
      第27回疫学会
    • Place of Presentation
      ベルクラシック甲府市(山梨件甲府市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] 子宮頸がん予防のグローバル戦略:一次予防と 二次予防 -自己採取HPV検査を含めて2016

    • Author(s)
      ハンリー シャロン
    • Organizer
      国際シンポジウム「子宮頸がん予防の戦略:検診とワクチン
    • Place of Presentation
      北海道大学学術交流会館、北海道、札幌市
    • Year and Date
      2016-03-16
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 日本における子宮頸がん罹患・死亡の現況と予防策2016

    • Author(s)
      櫻木範明
    • Organizer
      国際シンポジウム「子宮頸がん予防の戦略:検診とワクチン
    • Place of Presentation
      北海道大学学術交流会館、北海道、札幌市
    • Year and Date
      2016-03-16
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] Global Trends in Primary and Secondary Cervical Cancer Prevention:2016

    • Author(s)
      ハンリー シャロン
    • Organizer
      国際シンポジウム「子宮頸がん予防の戦略:検診とワクチン
    • Place of Presentation
      北海道大学フラテホール、北海道、札幌市
    • Year and Date
      2016-03-15
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 子宮頸がんの発生・進展とヒトパピローマウイルス(HPV)2016

    • Author(s)
      櫻木範明
    • Organizer
      北海道大学環境健康センターセミナー
    • Place of Presentation
      北海道大学環境健康科学研究教育センター、北海道、札幌市
    • Year and Date
      2016-02-19
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] HPV Self-Sampling-A Promising Alternative for Under-screened Women2016

    • Author(s)
      櫻木 範明
    • Organizer
      The 6th Hokkaido University-Fudan University Bilateral Symposium on Gynecologic Cancer and Endometriosis
    • Place of Presentation
      北海道大学(札幌市)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Sociodemographic, practical and attitudinal barriers to cervical screening in underscreened, never screened Japanese womem2016

    • Author(s)
      Sharon J. B. Hanley
    • Organizer
      Eurogin 2016
    • Place of Presentation
      Salzburg, Austria
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] HPV self-sampling is effective for engaging non-responders in cervical scree ning and identifying cervical abnormalities2016

    • Author(s)
      Sharon J. B. Hanley
    • Organizer
      第68回産科婦人科学会
    • Place of Presentation
      東京国際フォーラム(東京都千代田区)
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] HPV Self-Sampling as an Intervention to Increase Cervical Screening Uptake in Under-screened Japanese Women: A Randomized Control trial2015

    • Author(s)
      ハンリー シャロン
    • Organizer
      国際パピローマウイルス学会
    • Place of Presentation
      Lisbon, Portugal
    • Year and Date
      2015-09-17
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 新たな子宮頸がん検診システムの構築:受診率向上を目指した自己採取HPV検査の検討2015

    • Author(s)
      ハンリー シャロン
    • Organizer
      第24回日本婦人科がん検診学会
    • Place of Presentation
      ホテルさっぽろ芸文館、北海道、札幌市
    • Year and Date
      2015-08-21
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2018-03-22  

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