| Project/Area Number |
15K15231
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Hygiene and public health
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| Research Institution | Hirosaki University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
中路 重之 弘前大学, 医学研究科, 特任教授 (10192220)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | Helicobacter pylori / 生活習慣病 / 胃炎 / 骨減少症 / 脂質代謝 / 鉄代謝 / 腸内細菌叢 / ヘリコバクター・ピロリ / 血清脂質濃度 / ペプシノーゲン / 動脈硬化 / 脂質濃度 |
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| Outline of Final Research Achievements |
The association between Helicobacter pylori infection and life-style diseases are analyzed based on the data obtained in Iwaki Health Promotion Project. Serum level of estradiol and calcium intake, but not H. pylori infection, are associated with osteopenia in Japanese females. Lower serum level of ferritin was observed in Japanese patients with H. pylori infection. Eradication of H. pylori increased serum level of ferritin without corresponding increase of the intake of iron and vitamin C. Daly intake of lipid and cholesterol was not changed in both subjects with and without eradication. Eradication of H. pylori increased BMI and decreased serum level of LDL without corresponding changes in the intake of lipids. the rates of Lactobacillus in human gut microbiota would be influenced by H. pylori infection and significant increase was more appear in subjects with severe atrophic gastritis.
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