Reset of the epigenetic abnormality by dietary factors for cancer prevention
Project/Area Number |
15K15235
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Hygiene and public health
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Research Institution | Mie University |
Principal Investigator |
Murata Mariko 三重大学, 医学系研究科, 教授 (10171141)
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Co-Investigator(Kenkyū-buntansha) |
翠川 薫 三重大学, 医学系研究科, リサーチアソシエイト (20393366)
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Project Period (FY) |
2015-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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Keywords | 癌 / 食餌性因子 / DNA損傷 / エピゲノム異常 / DNAメチル化 |
Outline of Final Research Achievements |
Environmental factors including infection and inflammation induce the alteration of genome and epigenome, which may lead to carcinogenesis. Several reports suggest that dietary factors may change the status. First, we examined methods for quantification of DNA methylation, and we could get DNA methylation rates of candidate genes by Bisulfite Amplicon Sequencing (BAS) with high accuracy. In the endemic area of Epstein-Barr virus-associated nasopharyngeal carcinoma, there is an area having low incidence, and their custom of drinking tea attract attention. So, we are checking the effects of tea polyphenol, epigallocatechin gallate (EGCG) on DNA methylation rates and gene expression levels in human nasopharyngeal carcinoma cell lines.
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Report
(3 results)
Research Products
(65 results)
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[Journal Article] APOE Genotype in the Ethnic Majority and Minority Groups of Laos and the Implications for Non-Communicable Diseases.2016
Author(s)
Midorikawa K, Soukaloun D, Akkhavong K, Southivong B, Rattanavong O, Sengkhygnavong V, Pyaluanglath A, Sayasithsena S, Nakamura S, Midorikawa Y, Murata M.
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Journal Title
PLoS One
Volume: 11
Issue: 5
Pages: 1-15
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Epigenetic inactivation of follistatin-like 1 mediates tumor immune evasion in nasopharyngeal carcinoma.2016
Author(s)
Zhou X, Xiao X, Huang T, Du C, Wang S, Mo Y, Ma N, Murata M, Li B, Wen W, Huang G, Zeng X, Zhang Z
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Journal Title
Oncotarget
Volume: 7
Issue: 13
Pages: 16433-16444
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Glutaredoxin 3 promotes nasopharyngeal carcinoma growth and metastasis via EGFR/Akt pathway and independent of ROS.2016
Author(s)
He F, Wei L, Luo W, Liao Z, Li B, Zhou X, Xiao X, You J, Chen Y, Zheng S, Li P, Murata M, Huang G, Zhang Z
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Journal Title
Oncotarget.
Volume: 7
Issue: 24
Pages: 37000-37012
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Epigenetic downregulation of the ISG15-conjugating enzyme UbcH8 impairs lipolysis and correlates with poor prognosis in nasopharyngeal carcinoma.2015
Author(s)
Zhou X, Wei J, Chen F, Xiao X, Huang T, He Q, Wang S, Du C, Mo Y, Lin L, Xie Y, Wei L, Lan Y, Murata M, Huang G, Ernberg I, Matskova L, Zhang Z.
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Journal Title
Oncotarget.
Volume: 6(38)
Issue: 38
Pages: 41077-1091
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] Tumor suppressing roles of let-7c in head and neck cancer.2016
Author(s)
Bo Hou, Hajime Ishinaga, Kaoru Midorikawa, Ning Ma, Weilin Zhao, Shinji Oikawa, Yusuke Hiraku, Kazuhiko Takeuchi, Mariko Murata
Organizer
he 7th EMBO meeting 2016
Place of Presentation
Congress Center Rosengarten Mannheim(Mannheim, Germany)
Year and Date
2016-09-10
Related Report
Int'l Joint Research
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[Presentation] Inflammation-related DNA damage in relation to the expression of cancer stemness markers in human nasopharyngeal carcinoma.2015
Author(s)
Wang S, Ma N, Kawanishi S, Zhao W, Midorikawa K, Hiraku Y, Oikawa S, Zhang Z, Huang G, Murata M.
Organizer
SFRR-E/SNFS Meeting Stuttgart 2015: Redox Biology Meets Nutrition
Place of Presentation
ホ-エンハイム大学,シュトゥットガルト(ドイツ)
Year and Date
2015-09-01
Related Report
Int'l Joint Research
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