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Development of a PET imaging agent and disease biomarker for Alzheimer's disease.

Research Project

Project/Area Number 15K15237
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Hygiene and public health
Research InstitutionMie University

Principal Investigator

OIKAWA Shinji  三重大学, 医学系研究科, 准教授 (10277006)

Co-Investigator(Kenkyū-buntansha) 矢田 健一郎  三重大学, 医学系研究科, 産学官連携研究員 (40467361)
福原 潔  昭和大学, 薬学部, 教授 (70189968)
冨本 秀和  三重大学, 医学系研究科, 教授 (80324648)
Project Period (FY) 2015-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywordsアルツハイマー病 / プロテオミクス解析 / バイオマーカー / 抗酸化剤 / 高齢化 / エクソソーム / 活性酸素 / 酸化ストレス / トランスジェニックマウス / 早期診断法
Outline of Final Research Achievements

Alzheimer’s disease (AD) is the most common cause of dementia in elderly persons, with a rapidly increasing prevalence worldwide. AD is an irrevocable deleterious neurodegenerative disorder characterized by aggregated amyloid-beta (A beta) peptides and hyperphosphorylated tau protein. Thus, early diagnosis of AD is important. In this study, to identify candidate biomarkers for the early diagnosis of AD, we performed protein profiling of blood in patients with early AD. We also performed protein profiling of brain in P301S tau-transgenic (Tg) mouse. We found one protein that were significantly changed in the both plasma of AD patients and Tg mouse brain. In addition, we demonstrated that morin, a potential inhibitor of A beta-peptide aggregation, causes oxidative DNA damage in the presence of Cu(II). Thus, further studies are needed to demonstrate the oxidative pathway of morin in view of biomedical applications of morin for AD.

Academic Significance and Societal Importance of the Research Achievements

アルツハイマー病は、緩徐にしかし確実に脳を変性させる難治性疾患である。アルツハイマー病は記憶障害や認知障害が進行して生活に支障をきたすようになってから初めて臨床診断がなされ治療が開始されるが、根治的治療法は確立されていない。最近、アルツハイマー病の臨床診断前に早期発見し介入や予防的治療を行うことで、病気の進行や発症時期を遅らせ、健康寿命を伸ばすことが現実的な対策と考えられている。そのため、本研究では、検診などに応用できる血液を用いて、アルツハイマー病の早期診断バイオマーカーの探索を行った。また、アルツハイマー病の治療や診断に有用な物質の安全性も検討し、アルツハイマー病予防の基礎研究を行った。

Report

(5 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (76 results)

All 2019 2018 2017 2016 2015 Other

All Journal Article (21 results) (of which Int'l Joint Research: 10 results,  Peer Reviewed: 20 results,  Open Access: 13 results,  Acknowledgement Compliant: 5 results) Presentation (52 results) (of which Int'l Joint Research: 3 results) Remarks (2 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Mechanisms of DNA damage induced by morin, an inhibitor of amyloid β-peptide aggregation2019

    • Author(s)
      Mori Yurie、Kato Shinya、Fujisawa Yutaka、Ohnishi Shiho、Hiraku Yusuke、Kawanishi Shosuke、Murata Mariko、Oikawa Shinji
    • Journal Title

      Free Radical Research

      Volume: 53 Issue: 1 Pages: 115-123

    • DOI

      10.1080/10715762.2018.1562179

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Overexpression of CD44 Variant 9: A Novel Cancer Stem Cell Marker in Human Cholangiocarcinoma in Relation to Inflammation2018

    • Author(s)
      Suwannakul Nattawan、Ma Ning、Thanan Raynoo、Pinlaor Somchai、Ungarreevittaya Piti、Midorikawa Kaoru、Hiraku Yusuke、Oikawa Shinji、Kawanishi Shosuke、Murata Mariko
    • Journal Title

      Mediators of Inflammation

      Volume: 2018 Pages: 1-8

    • DOI

      10.1155/2018/4867234

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Proteomic profiling of exosomal proteins for blood-based biomarkers in Parkinson's Disease.2018

    • Author(s)
      Kitamura Y, Kojima M, Kurosawa T, Sasaki R, Ichihara S, Hiraku Y, Tomimoto H, Murata M, Oikawa S.
    • Journal Title

      Neuroscience

      Volume: 392 Pages: 121-128

    • DOI

      10.1016/j.neuroscience.2018.09.017

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Taurine exhibits an apoptosis-inducing effect on human nasopharyngeal carcinoma cells through PTEN/Akt pathways in vitro2018

    • Author(s)
      He Feng、Ma Ning、Midorikawa Kaoru、Hiraku Yusuke、Oikawa Shinji、Zhang Zhe、Huang Guangwu、Takeuchi Kazuhiko、Murata Mariko
    • Journal Title

      Amino Acids

      Volume: 50 Issue: 12 Pages: 1749-1758

    • DOI

      10.1007/s00726-018-2651-2

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Mechanism of oxidative DNA damage induced by metabolites of carcinogenic naphthalene2018

    • Author(s)
      Ohnishi Shiho、Hiraku Yusuke、Hasegawa Keishi、Hirakawa Kazutaka、Oikawa Shinji、Murata Mariko、Kawanishi Shosuke
    • Journal Title

      Mutat Res.

      Volume: 827 Pages: 42-49

    • DOI

      10.1016/j.mrgentox.2018.01.005

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Let-7c inhibits migration and epithelial-mesenchymal transition in head and neck squamous cell carcinoma by targeting IGF1R and HMGA22018

    • Author(s)
      Hou Bo、Ishinaga Hajime、Midorikawa Kaoru、Nakamura Satoshi、Hiraku Yusuke、Oikawa Shinji、Ma Ning、Takeuchi Kazuhiko、Murata Mariko
    • Journal Title

      Oncotarget

      Volume: 9 Issue: 10 Pages: 8927-8940

    • DOI

      10.18632/oncotarget.23826

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Nitrative DNA damage in cultured macrophages exposed to indium oxide2018

    • Author(s)
      Afroz T, Hiraku Y, Ma N, Ahmed S, Oikawa S, Kawanishi S, Murata M
    • Journal Title

      Journal of Occupational Health

      Volume: 60 Issue: 2 Pages: 148-155

    • DOI

      10.1539/joh.17-0146-OA

    • NAID

      130006565471

    • ISSN
      1341-9145, 1348-9585
    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Proteomics analysis identified peroxiredoxin 2 involved in early-phase left ventricular impairment in hamsters with cardiomyopathy.2018

    • Author(s)
      Kuzuya K, Ichihara S, Suzuki Y, Inoue C, Ichihara G, Kurimoto S, Oikawa S.
    • Journal Title

      PLoS One.

      Volume: 13 Issue: 2 Pages: e0192624-e0192624

    • DOI

      10.1371/journal.pone.0192624

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Plasma protein profiling for potential biomarkers in the early diagnosis of Alzheimer's disease.2017

    • Author(s)
      Kitamura Y, Usami R, Ichihara S, Kida H, Satoh M, Tomimoto H, Murata M, Oikawa S.
    • Journal Title

      Neurol Res.

      Volume: 39 Issue: 3 Pages: 231-238

    • DOI

      10.1080/01616412.2017.1281195

    • Related Report
      2017 Research-status Report 2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Complement Activation in Capillary Cerebral Amyloid Angiopathy2017

    • Author(s)
      Matsuo Ko、Shindo Akihiro、Niwa Atsushi、Tabei Ken-ichi、Akatsu Hiroyasu、Hashizume Yoshio、Akiyama Haruhiko、Ayaki Takashi、Maki Takakuni、Sawamoto Nobukatsu、Takahashi Ryosuke、Oikawa Shinji、Tomimoto Hidekazu
    • Journal Title

      Dement Geriatr Cogn Disord

      Volume: 44 Issue: 5-6 Pages: 343-353

    • DOI

      10.1159/000486091

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] RERG suppresses cell proliferation, migration and angiogenesis through ERK/NF-κB signaling pathway in nasopharyngeal carcinoma2017

    • Author(s)
      Zhao Weilin、Ma Ning、Wang Shumin、Mo Yingxi、Zhang Zhe、Huang Guangwu、Midorikawa Kaoru、Hiraku Yusuke、Oikawa Shinji、Murata Mariko、Takeuchi Kazuhiko
    • Journal Title

      Journal of Experimental & Clinical Cancer Research

      Volume: 36 Issue: 1 Pages: 88-88

    • DOI

      10.1186/s13046-017-0554-9

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Quantitation of DNA methylation in Epstein-Barr virus?associated nasopharyngeal carcinoma by bisulfite amplicon sequencing2017

    • Author(s)
      Zhao Weilin、Mo Yingxi、Wang Shumin、Midorikawa Kaoru、Ma Ning、Hiraku Yusuke、Oikawa Shinji、Huang Guangwu、Zhang Zhe、Murata Mariko、Takeuchi Kazuhiko
    • Journal Title

      BMC Cancer

      Volume: 17 Issue: 1 Pages: 489-489

    • DOI

      10.1186/s12885-017-3482-3

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Involvement of oxidative modification of proteins related to ATP synthesis in the left ventricles of hamsters with cardiomyopathy.2017

    • Author(s)
      Ichihara S, Suzuki Y, Chang J, Kuzuya K, Inoue C, Kitamura Y, Oikawa S.
    • Journal Title

      Sci Rep.

      Volume: 7 Issue: 1 Pages: 9243-9243

    • DOI

      10.1038/s41598-017-08546-1

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Nitrative and oxidative DNA damage in infection-related carcinogenesis in relation to cancer stem cells.2017

    • Author(s)
      Kawanishi S, Ohnishi S, Ma N, Hiraku Y, Oikawa S, Murata M.
    • Journal Title

      Genes Environ.

      Volume: 38 Issue: 1 Pages: 26-26

    • DOI

      10.1186/s41021-016-0055-7

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Inflammation-related DNA damage and cancer stem cell markers in nasopharyngeal carcinoma.2016

    • Author(s)
      Wang S, Ma N, Zhao W, Midorikawa K, Kawanishi S, Hiraku Y, Oikawa S, Zhang Z, Huang GW, Murata M.
    • Journal Title

      Mediators Inflamm.

      Volume: 2016 Pages: 9343460-9343460

    • DOI

      10.1155/2016/9343460

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] The potent tumor suppressor miR-497 inhibits cancer phenotypes in nasopharyngeal carcinoma by targeting ANLN and HSPA4L.2015

    • Author(s)
      Wang S, Mo Y, Midorikawa K, Zhang Z, Huang G, Ma N, Zhao W, Hiraku Y, Oikawa S, Murata M.
    • Journal Title

      Oncotarget

      Volume: 6 Issue: 34 Pages: 35893-35907

    • DOI

      10.18632/oncotarget.5651

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Oxidative DNA damage induced by metabolites of chloramphenicol, an antibiotic drug.2015

    • Author(s)
      Ohnishi S, Murata M, Ida N, Oikawa S, Kawanishi S.
    • Journal Title

      Free Radic Res.

      Volume: 49 Issue: 9 Pages: 1165-1172

    • DOI

      10.3109/10715762.2015.1050963

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Circulating microRNAs as novel prognosis biomarkers for head and neck squamous cell carcinoma.2015

    • Author(s)
      Hou B, Ishinaga H, Midorikawa K, Shah SA, Nakamura S, Hiraku Y, Oikawa S, Murata M, Takeuchi K. Circulating microRNAs as novel prognosis biomarkers for head and neck squamous cell carcinoma.
    • Journal Title

      Cancer Biol. Ther.

      Volume: 16 Issue: 7 Pages: 1042-1046

    • DOI

      10.1080/15384047.2015.1045692

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Melatonin induces apoptosis in cholangiocarcinoma cell lines by activating the reactive oxygen species-mediated mitochondrial pathway2015

    • Author(s)
      Laothong U, Hiraku Y, Oikawa S, Intuyod K, Murata M, Pinlaor S.
    • Journal Title

      Oncol Rep

      Volume: 33 Issue: 3 Pages: 1443-1449

    • DOI

      10.3892/or.2015.3738

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Hippocampal phosphoproteomics of F344 rats exposed to 1-bromopropane.2015

    • Author(s)
      Huang Z, Ichihara S, Oikawa S, Chang J, Zhang L, Hu S, Huang H, Ichihara G.
    • Journal Title

      Toxicol Appl Pharmacol

      Volume: 282 Issue: 2 Pages: 151-160

    • DOI

      10.1016/j.taap.2014.10.016

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Inflammation-related DNA damage in relation to the expression of cancer stemness markers in human nasopharyngeal carcinoma.2015

    • Author(s)
      Wang S, Ma N, Kawanishi S, Zhao W, Midorikawa K, Hiraku Y, Oikawa S, Zhang Z, Huang G, Murata M.
    • Journal Title

      Free Radic Biol Med.

      Volume: 86

    • Related Report
      2015 Research-status Report
    • Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] 軽度認知障害とアルツハイマー型認知症の血漿プロテオミクス解析2019

    • Author(s)
      森有利絵、本城貴志、山嶋哲盛、村田真理子、及川伸二
    • Organizer
      第89回日本衛生学会学術総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] RERG hypermethylation in circulating cell-free DNA of nasopharyngeal carcinoma: a potential hematological marker for screening2019

    • Author(s)
      Yifei Xu, Ning Ma, Kaoru Midorikawa, Yusuke Hiraku, Shinji Oikawa, Mariko Murata
    • Organizer
      第89回日本衛生学会学術総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Predominant expression levels of CD44 variants in cholangiocarcinoma cell line2019

    • Author(s)
      Nattawan Suwannakul, Ning Ma, Kaoru Midorikawa, Shinji Oikawa, Shosuke Kawanishi, Mariko Murata
    • Organizer
      第89回日本衛生学会総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Taurine exhibits an anti-proliferation effect on human nasopharyngeal carcinoma cells in vivo2019

    • Author(s)
      Feng He, Ning Ma, Kaoru Midorikawa, Yusuke Hiraku, Shinji Oikawa, Kazuhiko Takeuchi, Mariko Murata
    • Organizer
      第89回日本衛生学会学術総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] アルツハイマー病患者血漿エクソソーム中のタンパク質解析2019

    • Author(s)
      森咲子、森有利絵、山路隆斗、舩山華奈子、小嶋みどり、佐藤正之、市原佐保子、埜村智之、石川雅一、村田真理子、冨本秀和、及川伸二
    • Organizer
      日本酸化ストレス学会東海支部第7回学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 軽度認知障害患者血漿における酸化損傷タンパク質の解析2019

    • Author(s)
      宇野菜摘、森有利絵、宇野優市、山嶋哲盛、村田真理子、及川伸二
    • Organizer
      日本酸化ストレス学会東海支部第7回学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 軽度認知障害患者を対象としたアルツハイマー病の早期診断に関する血漿プロテオミクス解析2018

    • Author(s)
      森有利絵、本城貴志、北村祐貴、山嶋哲盛、村田真理子、及川伸二
    • Organizer
      第64回日本薬学会東海支部大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 虚血再灌流後のサル海馬CA1とDGにおけるプロテオミクス解析2018

    • Author(s)
      有利絵、栗本将多、北村祐貴、及川(多田)佐枝子、村田真理子、山嶋哲盛、及川伸二
    • Organizer
      71回日本酸化ストレス学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Taurine induces Apoptosis in Human Nasopharyngeal Carcinoma Cells through PTEN-mediated inhibition of Akt pathway in Vitro2018

    • Author(s)
      He, Ning Ma, Kaoru Midorikawa, Yusuke Hiraku, Shinji Oikawa, Kazuhiko Takeuchi, Mariko Murata
    • Organizer
      The 21st International Taurine Meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] GDF10 is a candidate tumor suppressor gene inactivated by promoter hypermethylation in human nasopharyngeal carcinoma2018

    • Author(s)
      Feng He, Ning Ma, Kaoru Midorikawa, Yusuke Hiraku, Shinji Oikawa, Zhe Zhang, Guangwu Huang, Kazuhiko Takeuchi, Mariko Murata
    • Organizer
      第77回日本癌学会学術総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] A novel cancer stem cell biomarker CD44v9 in liver fluke-related cholangiocarcinoma2018

    • Author(s)
      Nattawan Suwannakul, Ning Ma, Raynoo Thanan, Somchai Pinlaor, Kaoru Midorikawa, Yusuke Hiraku, Shinji Oikawa, Shosuke Kawanishi, Mariko Murata
    • Organizer
      第77回日本癌学会学術総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] DNA methylation in circulating cell-free DNA of nasopharyngeal carcinoma2018

    • Author(s)
      Yifei Xu, Ning Ma, Kaoru Midorikawa, Yusuke Hiraku, Shinji Oikawa, Zhe Zhang, Guangwu Huang, Kazuhiko Takeuchi, Mariko Murata
    • Organizer
      第77回日本癌学会学術総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 銅イオン及び鉄イオン存在下におけるフラボノイド類MorinによるDNA損傷機構2018

    • Author(s)
      森有利絵、加藤信哉、川西正祐、村田真理子、及川伸二
    • Organizer
      日本環境変異原学会第47回大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 金属イオン存在下Morinによる酸化的DNA損傷機構の解明.2018

    • Author(s)
      森有利絵、加藤信哉、川西正祐、村田真理子、及川伸二
    • Organizer
      第88回日本衛生学会総会
    • Related Report
      2017 Research-status Report
  • [Presentation] 早期アルツハイマー病患者における血液バイオマーカーの探索2018

    • Author(s)
      舩山華奈子、森有利絵、小嶋みどり、北村祐貴、佐藤正之、市原佐保子、埜村智之、石川雅一、村田真理子、冨本秀和、及川伸二.
    • Organizer
      日本酸化ストレス学会東海支部第6回学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] 膀胱がん患者組織における炎症関連DNA損傷とCOX2.2018

    • Author(s)
      大西志保、馬寧、村田真理子、平工雄介、及川伸二、川西正祐.
    • Organizer
      日本薬学会第138年会
    • Related Report
      2017 Research-status Report
  • [Presentation] Taurine inhibits proliferation and colony formation in nasopharyngeal carcinoma cells.2018

    • Author(s)
      Feng He , Ning Ma, Kaoru Midorikawa, Yusuke Hiraku, Shinji Oikawa, Mariko Murata.
    • Organizer
      第88 回日本衛生学会学術総会
    • Related Report
      2017 Research-status Report
  • [Presentation] Novel epigenetic markers for Epstein-Barr virus-associated nasopharyngeal carcinoma.2018

    • Author(s)
      Yifei Xu, Ning Ma, Kaoru Midorikawa, Yusuke Hiraku, Shinji Oikawa, Mariko Murata.
    • Organizer
      第88回日本衛生学会総会
    • Related Report
      2017 Research-status Report
  • [Presentation] Expression of a novel cancer stem cell biomarker, CD44 variant 9, in human cholangiocarcinoma.2018

    • Author(s)
      Nattawan Suwannakul, Ning Ma, Kaoru Midorikawa, Yusuke Hiraku, Shinji Oikawa, Shosuke Kawanishi,Mariko Murata.
    • Organizer
      第88回日本衛生学会総会
    • Related Report
      2017 Research-status Report
  • [Presentation] 膀胱がん患者組織における炎症関連因子とDNA損傷.2018

    • Author(s)
      大西志保、馬寧、村田真理子、平工雄介、及川伸二、川西正祐.
    • Organizer
      第88回日本衛生学会総会
    • Related Report
      2017 Research-status Report
  • [Presentation] 軽度認知障害の診断バイオマーカーの探索2017

    • Author(s)
      北村祐貴、近藤志織、本城貴志、山嶋哲盛、村田真理子、及川伸二
    • Organizer
      第87回日本衛生学会総会
    • Place of Presentation
      宮崎市、フェニックス・シーガイア・リゾート
    • Year and Date
      2017-03-26
    • Related Report
      2016 Research-status Report
  • [Presentation] Quantitative comparison of DNA methylation for biomarker in Epstein-Barr virus-associated nasopharyngeal carcinoma.2017

    • Author(s)
      Weilin Zhao, Kaoru Midorikawa, Ning Ma, Yusuke Hiraku, Shinji Oikawa, Mariko Murata.
    • Organizer
      第 87回 日本衛生学会学術総会
    • Place of Presentation
      宮崎市、フェニックス・シーガイア・リゾート
    • Year and Date
      2017-03-26
    • Related Report
      2016 Research-status Report
  • [Presentation] Let-7c inhibits migration and epithelial-mesenchymal transition by targeting IGF1R and HMGA2 in head and neck cancer cells.2017

    • Author(s)
      Bo Hou, Kaoru Midorikawa, Yusuke Hiraku, Shinji Oikawa, Ning Ma, Mariko Murata.
    • Organizer
      第 87回 日本衛生学会学術総会
    • Place of Presentation
      宮崎市、フェニックス・シーガイア・リゾート
    • Year and Date
      2017-03-26
    • Related Report
      2016 Research-status Report
  • [Presentation] 寄生虫感染による膀胱癌患者組織における炎症関連DNA損傷とCOX2発現.2017

    • Author(s)
      大西志保、馬寧、村田真理子、平工雄介・及川伸二、小林果、川西正祐.
    • Organizer
      第87 回日本衛生学会学術総会
    • Place of Presentation
      宮崎市、フェニックス・シーガイア・リゾート
    • Year and Date
      2017-03-26
    • Related Report
      2016 Research-status Report
  • [Presentation] Increased expression of Glutaredoxin 3 promotes the proliferation and metastasis of nasopharyngeal carcinoma.2017

    • Author(s)
      Feng He, Kaoru Midorikawa, Yusuke Hiraku, Shinji Oikawa, Ning Ma, Mariko Murata.
    • Organizer
      第87 回日本衛生学会学術総会
    • Place of Presentation
      宮崎市、フェニックス・シーガイア・リゾート
    • Year and Date
      2017-03-26
    • Related Report
      2016 Research-status Report
  • [Presentation] 2D-DIGE 法を用いた軽度認知障害患者の血漿タンパク質のプロファイリング2017

    • Author(s)
      近藤志織、北村祐貴、本城貴志、山嶋哲盛、村田真理子、及川伸二
    • Organizer
      日本酸化ストレス学会東海支部第 5 回学術集会
    • Place of Presentation
      名古屋市、愛知学院大学名城公園キャンパス
    • Year and Date
      2017-02-18
    • Related Report
      2016 Research-status Report
  • [Presentation] アントラキノン系天然色素Purpurinによる塩基配列特異的DNA損傷2017

    • Author(s)
      森有利絵、加藤信哉、村田真理子、川西正祐、及川伸二
    • Organizer
      日本環境変異原学会第46回大会
    • Related Report
      2017 Research-status Report
  • [Presentation] RERG suppresses cell proliferation and angiogenesis by inhibiting the ERK/NF-κB/MMPs signaling pathway in nasopharyngeal carcinoma.2017

    • Author(s)
      Weilin Zhao, Ning Ma, Kaoru Midorikawa, Yingxi Mo, Zhe Zhang, Guangwu Huang, Yusuke Hiraku, Shinji Oikawa, Kazuhiko Takeuchi, Mariko Murata.
    • Organizer
      第76回日本癌学会学術総会
    • Related Report
      2017 Research-status Report
  • [Presentation] Inhibitory effects of taurine on the proliferation in nasopharyngeal carcinoma cells.2017

    • Author(s)
      Feng He, Kaoru Midorikawa, Yusuke Hiraku, Shinji Oikawa, Ning Ma, Kazuhiko Takeuchi, Mariko Murata.
    • Organizer
      第76回日本癌学会学術総会
    • Related Report
      2017 Research-status Report
  • [Presentation] Inflammation-related DNA damage and COX-2 in bladder cancer tissues from patients infected with Schistosoma haematobium.2017

    • Author(s)
      大西志保、馬寧、村田真理子、平工雄介、及川伸二、川西正祐.
    • Organizer
      第76回日本癌学会学術総会
    • Related Report
      2017 Research-status Report
  • [Presentation] アルツハイマー病患者血漿エクソソーム内タンパク質の発現量解析2017

    • Author(s)
      小嶋みどり、北村裕貴、森有利絵、木田博隆、佐藤正之、市原佐保子、埜村智之、石川雅一、村田真理子、冨本秀和、及川伸二.
    • Organizer
      日本プロテオーム学会2017大会
    • Related Report
      2017 Research-status Report
  • [Presentation] アルツハイマー病患者の血漿中カルボニル化タンパク質のプロテオミクス解析2017

    • Author(s)
      辻本佳世、北村裕貴、森有利絵、木田博隆、佐藤正之、市原佐保子、埜村智之、石川雅一、村田真理子、冨本秀和、及川伸二.
    • Organizer
      日本プロテオーム学会2017大会
    • Related Report
      2017 Research-status Report
  • [Presentation] 軽度認知障害の診断バイオマーカーの探索2017

    • Author(s)
      近藤志織、北村祐貴、本城貴志、山嶋哲盛、村田真理子、及川伸二.
    • Organizer
      日本プロテオーム学会2017大会
    • Related Report
      2017 Research-status Report
  • [Presentation] Nitrative DNA damage in cultured cwells exposed to indium compounds2017

    • Author(s)
      Sharif Ahmed, Tahmina Afroz、馬寧、及川伸二、川西正祐、村田真理子、平工雄介.
    • Organizer
      第63回東海公衆衛生学会学術大会
    • Related Report
      2017 Research-status Report
  • [Presentation] NNKが誘導したマウス肺がんに対するヤマブドウ抽出画分の肺発がん抑制効果に関与するタンパク質の同定2016

    • Author(s)
      北村祐貴、三宅直子、有元佐賀惠、村田真理子、及川伸二
    • Organizer
      第45回日本環境変異原学会
    • Place of Presentation
      つくば市、つくば国際会議場
    • Year and Date
      2016-11-17
    • Related Report
      2016 Research-status Report
  • [Presentation] Let-7c functions as a tumor suppressor by targeting HMGA2 in head and neck cancer.2016

    • Author(s)
      Bo Hou, Kaoru Midorikawa, Hajime Ishinaga, Ning Ma, Shinji Oikawa, Yusuke Hiraku, Kazuhiko Takeuchi, Mariko Murata.
    • Organizer
      第75回日本癌学会総会
    • Place of Presentation
      横浜市、パシフィコ横浜
    • Year and Date
      2016-10-06
    • Related Report
      2016 Research-status Report
  • [Presentation] PRKCB, a tumor suppressor, is epigenetically inactivated in nasopharyngeal carcinoma2016

    • Author(s)
      Weilin Zhao, Shumin Wang, Kaoru Midorikawa, Zhe Zhang, Yingxi Mo, Guangwu Huang, Ning Ma, Yusuke Hiraku, Shinji Oikawa, Kazuhiko Takeuchi, Mariko Murata
    • Organizer
      第75回日本癌学会学術総会
    • Place of Presentation
      横浜市、パシフィコ横浜
    • Year and Date
      2016-10-06
    • Related Report
      2016 Research-status Report
  • [Presentation] Tumor suppressing roles of let-7c in head and neck cancer.2016

    • Author(s)
      Bo Hou, Hajime Ishinaga, Kaoru Midorikawa, Ning Ma, Weilin Zhao, Shinji Oikawa, Yusuke Hiraku, Kazuhiko Takeuchi, Mariko Murata
    • Organizer
      The 7th EMBO meeting 2016
    • Place of Presentation
      Congress Center Rosengarten Mannheim, Germany
    • Year and Date
      2016-09-10
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] パーキンソン病患者血漿中のカルボニル化タンパク質の解析2016

    • Author(s)
      北村祐貴、佐々木良元、市原佐保子、埜村智之、石川雅一、水野章、村田真理子、冨本秀和、及川伸二
    • Organizer
      69回日本酸化ストレス学会学術集会
    • Place of Presentation
      仙台市、仙台国際センター
    • Year and Date
      2016-08-30
    • Related Report
      2016 Research-status Report
  • [Presentation] タバコ煙中発がん物質による肺がんマウスに対するサルナシ果汁の発がん抑制効果における比較プロテオミクス解析2016

    • Author(s)
      北村祐貴、三宅直子、有元佐賀惠、村田真理子、及川伸二
    • Organizer
      第62回東海公衆衛生学会学術大会
    • Place of Presentation
      豊橋市、穂の国とよはし芸術劇場プラット
    • Year and Date
      2016-07-16
    • Related Report
      2016 Research-status Report
  • [Presentation] タバコ特異的ニトロサミンNNK誘導マウス肺がんに対するヤマブドウ成分の発がん抑制効果における比較プロテオミクス解析2016

    • Author(s)
      北村祐貴、有元佐賀惠、谷本雄亮、久保寿夫、木浦勝行、村田真理子、及川伸二
    • Organizer
      第23回日本がん予防学会総会
    • Place of Presentation
      名古屋市、名古屋大学鶴舞キャンパス
    • Year and Date
      2016-07-01
    • Related Report
      2016 Research-status Report
  • [Presentation] 筋萎縮性側索硬化症の脳脊髄液における酸化損傷タンパク質の同定2016

    • Author(s)
      北村祐貴、菰田淳、二本松綾乃、佐々木良元、村田真理子、冨本秀和、及川伸二
    • Organizer
      第80回日本生化学会中部支部例会・シンポジウム
    • Place of Presentation
      津市、三重大学講堂
    • Year and Date
      2016-05-21
    • Related Report
      2016 Research-status Report
  • [Presentation] パーキンソン病の血漿中エクソソームのプロテオミクス解析2016

    • Author(s)
      北村祐貴、佐々木良元、市原佐保子、埜村智之、石川雅一、水野章、村田真理子、冨本秀和、及川伸二
    • Organizer
      第86回日本衛生学会学術総会
    • Place of Presentation
      旭川市、旭川市民文化会館
    • Year and Date
      2016-05-11
    • Related Report
      2016 Research-status Report
  • [Presentation] Let-7c functions as a tumor suppressor by targeting IGF1R in head and neck cancer.2016

    • Author(s)
      Bo Hou, Kaoru Midorikawa, Yusuke Hiraku, Shinji Oikawa, Ning Ma, Mariko Murata
    • Organizer
      第86 回日本衛生学会学術総会
    • Place of Presentation
      旭川市、旭川市民文化会館
    • Year and Date
      2016-05-11
    • Related Report
      2016 Research-status Report
  • [Presentation] Hypermethylation of RERG promoter in nasopharyngeal carcinoma.2016

    • Author(s)
      Weilin Zhao, Shumin Wang, Kaoru Midorikawa, Ning Ma, Yusuke Hiraku , Shinji Oikawa, Mariko Murata
    • Organizer
      第86 回日本衛生学会学術総会
    • Place of Presentation
      旭川市、旭川市民文化会館
    • Year and Date
      2016-05-11
    • Related Report
      2016 Research-status Report
  • [Presentation] パーキンソン病患者血漿中の酸化損傷タンパク質の解析2016

    • Author(s)
      北村祐貴、佐々木良元、市原佐保子、埜村智之、石川雅一、水野章、村田真理子、冨本秀和、及川伸二
    • Organizer
      日本酸化ストレス学会東海支部第4回学術大会
    • Place of Presentation
      鈴鹿市、鈴鹿医療科学大学
    • Year and Date
      2016-02-06
    • Related Report
      2015 Research-status Report
  • [Presentation] NNK誘導マウス肺がんに対するサルナシ果汁の肺発がん抑制効果における比較プロテオミクス解析2015

    • Author(s)
      北村祐貴、三宅直子、有元佐賀惠、村田真理子、及川伸二
    • Organizer
      第44回日本環境変異原学会
    • Place of Presentation
      福岡市、九州大学馬出キャンパス
    • Year and Date
      2015-11-27
    • Related Report
      2015 Research-status Report
  • [Presentation] 早期アルツハイマー病患者の血漿中バイオマーカーの探索2015

    • Author(s)
      北村祐貴、本城貴志、山嶋哲盛、及川伸二
    • Organizer
      第24回海馬と高次脳機能学会
    • Place of Presentation
      岐阜市、岐阜大学サテライトキャンパス
    • Year and Date
      2015-10-10
    • Related Report
      2015 Research-status Report
  • [Presentation] 頭頸部扁平上皮癌におけるマイクロRNA let-7c とその標的遺伝子の役割2015

    • Author(s)
      侯波、石永一、翠川薫、王淑民、趙蔚林、及川伸二、平工雄介、馬寧、竹内万彦、村田真理子
    • Organizer
      第74 回日本癌学会学術総会
    • Place of Presentation
      名古屋市、名古屋国際会議場
    • Year and Date
      2015-10-08
    • Related Report
      2015 Research-status Report
  • [Presentation] 上咽頭癌における癌抑制遺伝子候補のプロモーター領域DNA の高度メチル化2015

    • Author(s)
      趙蔚林、王淑民、翠川薫、張哲、莫頴禧、黄光武、馬寧、平工雄介、及川伸二、村田真理子
    • Organizer
      第74 回日本癌学会学術総会
    • Place of Presentation
      名古屋市、名古屋国際会議場
    • Year and Date
      2015-10-08
    • Related Report
      2015 Research-status Report
  • [Presentation] Inflammation-related DNA damage in relation to the expression of cancer stemness markers in human nasopharyngeal carcinoma.2015

    • Author(s)
      Wang S, Ma N, Kawanishi S, Zhao W, Midorikawa K, Hiraku Y, Oikawa S, Zhang Z, Huang G, Murata M.
    • Organizer
      SFRR-E/SNFS Meeting Stuttgart 2015: Redox Biology Meets Nutrition,
    • Place of Presentation
      ホ-エンハイム大学,ドイツ・シュトゥットガルト
    • Year and Date
      2015-09-01
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 筋萎縮性側索硬化症の脳脊髄液におけるカルボニル化タンパク質の解析2015

    • Author(s)
      北村祐貴、菰田淳、二本松綾乃、佐々木良元、村田真理子、冨本秀和、及川伸二
    • Organizer
      日本プロテオーム学会2015年会
    • Place of Presentation
      熊本市、熊本森都心プラザ
    • Year and Date
      2015-07-23
    • Related Report
      2015 Research-status Report
  • [Remarks] 三重大学大学院医学系研究科 環境分子医学 HP

    • URL

      http://www.medic.mie-u.ac.jp/eiseigaku/

    • Related Report
      2017 Research-status Report
  • [Remarks] 三重大学大学院医学系研究科 環境分子医学

    • URL

      http://www.medic.mie-u.ac.jp/eiseigaku/

    • Related Report
      2016 Research-status Report
  • [Patent(Industrial Property Rights)] 脳アミロイド血管症の末梢血バイオマーカー2017

    • Inventor(s)
      冨本 秀和、他
    • Industrial Property Rights Holder
      国立大学法人三重大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2017
    • Related Report
      2017 Research-status Report

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Published: 2015-04-16   Modified: 2020-03-30  

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