| Project/Area Number |
15K15243
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Hygiene and public health
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | カドミウム / 銅 / ラット / 腎障害 / 貧血 / メタロチオネイン |
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| Outline of Final Research Achievements |
To consider the effect of cupper in the body on the development of chronic cadmium toxicity, rats were injected with cadmium at 2mg/kg once a week for 3 months (saline to control rats) fed by cupper deficient diets. Cadmium induced an elevation of hepatic cupper concentration, renal tubular dysfunction, renal anemia accompanied with a decrease of serum iron, etc. Feeding cupper deficient diets in addition to cadmium injection, an increase in renal excretion of protein and slight enhancement of anemia were observed. These results suggest that cupper deficiency, although only slightly, have an effect to enhance cadmium toxicity.
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