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Associations between autistic traits induced by dioxin exposure and mirror neuron systems

Research Project

Project/Area Number 15K15244
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Hygiene and public health
Research InstitutionKanazawa Medical University

Principal Investigator

NISHIJO Muneko  金沢医科大学, 医学部, 教授 (40198461)

Co-Investigator(Renkei-kenkyūsha) MORIKAWA Yuko  金沢医科大学, 看護学部, 教授 (20210156)
NISHIJO Hisao  富山大学, 医学(系)研究科(大学院), 教授 (00189284)
Research Collaborator Pham Ngoc Thao  ベトナム軍医科大学
Nghiem Thi Thuy Giang  ベトナム軍医科大学
Pham The Tai  ベトナム軍医科大学
Phoung Van Luong  ベトナム軍医科大学
Tran Hai Anh  ベトナム軍医科大学
Tran Ngoc Nghi  ベトナム厚生省
Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywordsダイオキシン / 視線 / 自閉症傾向 / ミラーニューロン / 小児 / ベトナム / 自閉症 / 脳波 / 脳神経発達
Outline of Final Research Achievements

We investigated effects of dioxins on eye tracking of 167 children aged 3 years old living in heavily exposed area in Vietnam using eye-tracker. At first, we compared location and time of gaze on some pictures with faces and activity of children in autistic children with those in healthy children. For the results, we found that gaze of autistic children on several pictures with faces stayed for shorter time compared with healthy children. Then, we compared frequency of children who focus on pictures only for a short time (25 percentile of gaze time) between high and low TCDD groups. The frequency was higher in high TCDD group in girls when 2 pictures with faces were shown to them.
For 37 children aged 8 years old, we investigated decreasing power of mu-wave in them when video of moving hands were shown to them. We observed decreased mu-wave by watching hand movements, but the degree of decreased power was not associated with dioxin exposure.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • Research Products

    (4 results)

All 2016 Other

All Int'l Joint Research (2 results) Presentation (2 results)

  • [Int'l Joint Research] ベトナム軍医科大学/ベトナム厚生省(ベトナム)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] ベトナム軍医科大学/べトナム厚生省(ベトナム)

    • Related Report
      2015 Research-status Report
  • [Presentation] A case control study of neurotoxic effects of perinatal dioxin exposure on children of 2 years of age in Vietnam2016

    • Author(s)
      Pham Ngoc Thao, Muneko Nishijo, Pham The Tai, Hisao Nishijo, Shinya Nagasawa, Yoshikazu Nishino
    • Organizer
      5th Conference on Prenatal Programming and Toxicity
    • Place of Presentation
      北九州国際会議場(福岡県北九州市)
    • Year and Date
      2016-11-13
    • Related Report
      2016 Annual Research Report
  • [Presentation] Associations of dioxin levels between in maternal breast milk and umbilical cord blood in a dioxin hot spot in Bien Hoa city, Vietnam2016

    • Author(s)
      Tran Ngoc Nghi, Muneko Nishijo, Pham-The Tai, Yoshikazu Nishino,Hoang Van Luong, Tran Hai Anh ,Yuko Morikawa, Pham Ngoc Thao, Nishijo H
    • Organizer
      第86回日本衛生学会総会
    • Place of Presentation
      旭川市民文化会館(北海道旭川市)
    • Year and Date
      2016-05-11
    • Related Report
      2016 Annual Research Report

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Published: 2015-04-16   Modified: 2018-03-22  

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