Development of auto-release system of non-toxic anti-fungal compounds triggered by enzymes produced by fungus itself.

Research Project

Project/Area Number	15K15247
Research Category	Grant-in-Aid for Challenging Exploratory Research
Allocation Type	Multi-year Fund
Research Field	Hygiene and public health
Research Institution	National Institute of Advanced Industrial Science and Technology
Principal Investigator	Yamaguchi Munehiro 国立研究開発法人産業技術総合研究所, 生命工学領域, 研究グループ付 (60358231)
Co-Investigator(Kenkyū-buntansha)	佐々木正秀国立研究開発法人産業技術総合研究所, 生命工学領域, 副研究部門長 (60357126) 清水弘樹国立研究開発法人産業技術総合研究所, 生命工学領域, 主任研究員 (30344716) 西村麻里江国立研究開発法人農業生物資源研究所, その他部局等, 主任研究員 (30370670)
Project Period (FY)	2015-04-01 – 2019-03-31
Project Status	Completed (Fiscal Year 2018)
Budget Amount *help	¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000) Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000) Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords	衛生 / 抗カビシステム、 / 機能性表面 / 酵素反応 / 菌類 / 抗カビシステム
Outline of Final Research Achievements	Fungus in the living circumstance could be caused health problems such as allergies. Marketed fungicides have the effect sterilizing fungus but tend to be overused due to their persistent, and many are chemicals which are harmful to the human body and the environment. In this study, we tried to find non-toxic anti-fungal active natural compounds and release it in suitable area, suitable time and suitable amount automatically triggered by enzymes produced by fungus itself.
Academic Significance and Societal Importance of the Research Achievements	抗カビ活性物質オートリリースシステムが確立できれば、本システムは大規模な施設投資なしに導入可能で、特に、過剰なカビ取り剤の散布が好ましくない老人施設・病院の室内設備や食品加工場・厨房施設など公共衛生施設などに有効と考えられる。