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Development of metal nano particle-based infection control system

Research Project

Project/Area Number 15K15253
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Medical and hospital managemen
Research InstitutionJuntendo University

Principal Investigator

SEKINE MIWA  順天堂大学, 医学(系)研究科(研究院), 助教 (10398670)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywordsナノ粒子 / 黄色ブドウ球菌 / 院内感染 / 感染対策 / 細胞毒性 / 殺菌活性
Outline of Final Research Achievements

The goal of this research is to develop simpler and more effective infection prevention system for the prevalence of widespread nosocomial infection and expansion of drug resistant Staphylococcus aureus such as VISA (Methicillin-resistant strain with vancomycin-intermediate resistance) infection.
The main achievements are as follows; 1) Confirming the bactericidal effect and bacteriostatic effect of platinum nanoparticles, 2) Discovering the platinum nanoparticle dispersion has little or no cytotoxicity on conventional cultured human cells, 3) Finding that platinum nanoparticle dispersion does not induce inflammatory cytokine secretion. These results revealed that it is highly possible that protection against infection by platinum nanoparticles can be effective.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (2 results)

All 2018 2016

All Presentation (2 results)

  • [Presentation] Investigation into bactericidal effect of Platinum nano particles2018

    • Author(s)
      Miwa Sekine, Kyoko Kuwahara, Teruo Kirikae, Keiichi Hiramatsu
    • Organizer
      第91回日本細菌学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 黄色ブドウ球菌に対する金属ナノ粒 子の殺菌効果の検討2016

    • Author(s)
      関根美和
    • Organizer
      第31回日本環境感染学会総会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2016-02-19
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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