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Study on a differential diagnostic marker for endogenous and exogenous brain injury: Analysis of COX expression property

Research Project

Project/Area Number 15K15260
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Legal medicine
Research InstitutionUniversity of Yamanashi

Principal Investigator

SHOJO Hideki  山梨大学, 大学院総合研究部, 准教授 (60284626)

Co-Investigator(Kenkyū-buntansha) 馬淵 正  山梨大学, 総合研究部, 助教 (80150308)
Co-Investigator(Renkei-kenkyūsha) ADACHI Noboru  山梨大学, 大学院総合研究部, 教授 (60282125)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords頭部外傷 / シクロオキシゲナーゼ / 内因性・外因性脳損傷診断マーカー
Outline of Final Research Achievements

The goal of current study was to determine whether cyclooxygenase (COX) is useful as a molecular marker for endogenous and extrinsic brain injury differential diagnosis. Here, we elucidated the molecular dynamics of COX1 and 2, which are involved in inflammation and anti-inflammation of the central nervous system in the damaged brain after trauma. In the brain after trauma, COX1 was predominantly in degenerative neurons, while COX2 was expressed in neurons and macrophages. In addition, COX expression patterns reflect the pathological characteristics of various brain diseases, suggesting that COX may be useful as a molecular marker for endogenous and exogenous brain injury differential diagnosis.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (9 results)

All 2018 2017 2015 Other

All Int'l Joint Research (1 results) Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (3 results) (of which Int'l Joint Research: 1 results) Remarks (4 results)

  • [Int'l Joint Research] 南フロリダ大学老化・脳修復研究所(米国)

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Genetic and Histological Alterations Reveal Key Role of Prostaglandin Synthase and Cyclooxygenase 1 and 2 in Traumatic Brain Injury-Induced Neuroinflammation in the Cerebral Cortex of Rats Exposed to Moderate Fluid Percussion Injury.2017

    • Author(s)
      Shojo H, Borlongan CV, Mabuchi T.
    • Journal Title

      Cell Transplant.

      Volume: 26 Issue: 7 Pages: 1301-1313

    • DOI

      10.1177/0963689717715169

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Develppment of forensic biomarker for brain ischemia: Analyses of mitochondrial function and morphology in the brain ischemia model neurons2018

    • Author(s)
      Shojo H, Adachi N
    • Organizer
      24th Congress of the International Academy of Legal Medicine, Fukuoka International Congress Center (Fukuoka, Japan)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 脳虚血モデル神経培養細胞を用いたミトコンドリアの形態解析2017

    • Author(s)
      猩々英紀、安達登
    • Organizer
      第101次日本法医学会学術全国集会,長良川国際会議場(岐阜県・岐阜市)
    • Related Report
      2017 Annual Research Report
  • [Presentation] 頭部外傷によるシクロオキシゲナーゼの発現変化2015

    • Author(s)
      猩々英紀、馬淵正
    • Organizer
      第38回分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド(兵庫県・神戸市)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Research-status Report
  • [Remarks] 山梨大学大学院総合研究部法医学講座猩々英紀

    • URL

      https://www.med.yamanashi.ac.jp/social/legal0me/classroom_member/shohjoh.html

    • Related Report
      2017 Annual Research Report
  • [Remarks] 山梨大学大学院総合研究部法医学講座猩々英紀

    • URL

      http://www.med.yamanashi.ac.jp/social/legal0me/classroom_member/shohjoh.html

    • Related Report
      2016 Research-status Report
  • [Remarks] 山梨大学研究者総覧―猩々英紀

    • URL

      http://erdb.yamanashi.ac.jp/rdb/A_DispInfo.Scholar/3_61/F8AD215DD10A64A4.html

    • Related Report
      2016 Research-status Report 2015 Research-status Report
  • [Remarks] 山梨大学大学院総合研究部法医学講座 猩々英紀

    • URL

      http://www.med.yamanashi.ac.jp/social/legal0me/classroom_member/shohjoh.html

    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2022-06-07  

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