| Project/Area Number |
15K15264
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Legal medicine
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
野坂 みずほ 和歌山県立医科大学, 医学部, 助教 (00244731)
石田 裕子 和歌山県立医科大学, 医学部, 講師 (10364077)
木村 章彦 和歌山県立医科大学, 医学部, 准教授 (60136611)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | autophagy / 体内時計 / 創傷治癒 / 損傷の生活反応 / 法医診断 / オートファジー / 損傷診断 |
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| Outline of Final Research Achievements |
We found that autophagy was quickly suppressed in the skin wound tissue after infliction, which might be a useful marker for wound vitality in the forensic practice. Conversely, we found that Rev-erb-alpha and ROR-gamma of clock genes markedly increased at the protein level in the wound tissue. Since suppression of autophagy by treatment with 3-Methyladenine increased ROR-gamma, autophagy suppression seemed to induce an increase of ROR-gamma protein in the wound tissue.
These changes in the wound tissue revealed that they act on Keap 1/Nrf 2 system and induce the expression of antioxidant genes, thereby contributing to promotion of wound healing.
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