| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Outline of Final Research Achievements |
How to cope with stress-related disorders is a crucial problem to solve in the modern society. Irritable bowel syndrome (IBS) is an appropriate disorder to find a hint to do so. We verified the hypothesis that genetic polymorphism of substances regulating hypothalamic-pituitary-adrenocortical axis may affect the phenotype of IBS via proteins/metabolites. Subjects were IBS patients and healthy controls. DNA was extracted from the blood. Genotyping, phenotyping and psycho-behavioral analyses were performed. These genotypes did not directly relate to IBS phenotypes. However, these genotypes were found to be associated with psycho-behavioral factors relating IBS. The hypothesis was thus supported. Findings in this study have scientific and social significance because they can be expanded to the other stress-related disorders.
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