Identification of Substances that Relate to Irritable Bowel Syndrome
Project/Area Number |
15K15267
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
General internal medicine(including psychosomatic medicine)
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Research Institution | Tohoku University |
Principal Investigator |
Fukudo Shin 東北大学, 医学系研究科, 教授 (80199249)
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Research Collaborator |
KANAZAWA Motoyori
ENDO Yuka
SHOJI Tomotaka
KANO Michiko
MURATSUBAKI Tomohiko
TANAKA Yukari
SASAKI Ayaka
KOMURO Hazuki
SUGAI Chinami
YAMADA Akiko
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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Keywords | 脳腸相関 / 過敏性腸症候群 / 遺伝子 / ストレス / 炎症 / 消化管運動 / 消化管知覚 / 神経伝達物質 |
Outline of Final Research Achievements |
How to cope with stress-related disorders is a crucial problem to solve in the modern society. Irritable bowel syndrome (IBS) is an appropriate disorder to find a hint to do so. We verified the hypothesis that genetic polymorphism of substances regulating hypothalamic-pituitary-adrenocortical axis may affect the phenotype of IBS via proteins/metabolites. Subjects were IBS patients and healthy controls. DNA was extracted from the blood. Genotyping, phenotyping and psycho-behavioral analyses were performed. These genotypes did not directly relate to IBS phenotypes. However, these genotypes were found to be associated with psycho-behavioral factors relating IBS. The hypothesis was thus supported. Findings in this study have scientific and social significance because they can be expanded to the other stress-related disorders.
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Report
(3 results)
Research Products
(19 results)
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[Presentation] Effect of ramosetron in female patients with irritable bowel syndrome with diarrhea: a randomized, placebo-controlled phase III trial.2015
Author(s)
Fukudo, Shin; Kinoshita, Yoshikazu; Okumura, Toshikatsu; Ida, Motoko; Akiho, Hiraku; Nakashima, Yoshihiro; Nishida, Akito; Haruma, Ken.
Organizer
The 116th Annual Meeting of American Gastroenterological Association (46th Annual Digestive Disease Week)
Place of Presentation
Washington DC, USA
Year and Date
2015-05-16
Related Report
Int'l Joint Research
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