• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Establishment of a diagnostic method of amyloidosis with PET

Research Project

Project/Area Number 15K15268
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field General internal medicine(including psychosomatic medicine)
Research InstitutionTohoku Medical and Pharmaceutical University (2016)
Tohoku University (2015)

Principal Investigator

FURUKAWA Katsutoshi  東北医科薬科大学, 医学部, 教授 (30241631)

Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsアミロイドーシス / PET / アミロイド / アルツハイマー病
Outline of Final Research Achievements

In any of the amyloidgenic disorders, it is surmised that the monomer of the amyloid protein itself is not very toxic, while misfolded oligomers could cause damage to organs. It is, therefore, truly important to detect the accumulation of real amyloid fibrils for early and accurate diagnosis of amyloidosis. In order to visualize amyloid deposition, the patients with amyloidosis (Alzheimer's disease, rheumatoid arthritis, multiple myeloma, etc) underwent a positron emission tomography (PET) study with a amyloid specific PET tracer, [11C]-BF227. The PET images revealed significantly robust retention of [11C]-BF227 in the patients with amyloidosis compared to that of the normal control. To our knowledge, this is the first report showing the usefulness of a beta-pleated sheet structure-specific PET in investing visceral organ amyloidosis. Therefore, we will be continuing the effort to improve this PET technology with BF227 for the diagnosis of amyloidosis.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • Research Products

    (20 results)

All 2017 2016 2015 2014

All Journal Article (13 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 12 results,  Acknowledgement Compliant: 6 results,  Open Access: 3 results) Presentation (7 results) (of which Int'l Joint Research: 3 results)

  • [Journal Article] Accurate quantitation of choline and ethanolamine plasmalogen molecular species in human plasma by liquid chromatography-tandem mass spectrometry.2017

    • Author(s)
      Otoki Y et al.
    • Journal Title

      J Pharm Biomed Anal.

      Volume: 134 Pages: 77-85

    • DOI

      10.1016/j.jpba.2016.11.019

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tau imaging with [18F]THK-5351 in progressive supranuclear palsy.2017

    • Author(s)
      Ishiki A, Harada R, Okamura N, Tomita N, Rowe CC, Villemagne VL, Yanai K, Kudo Y, Arai H, Furumoto S, Tashiro M, Furukawa K.
    • Journal Title

      Eur J Neurol.

      Volume: 24 Issue: 1 Pages: 130-136

    • DOI

      10.1111/ene.13164

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Subgroup differences in 'brain-type' transferrin and α-synuclein in Parkinson's disease and multiple system atrophy.2016

    • Author(s)
      Yoshihara A, Fukatsu M, Hoshi K, Ito H, Nollet K, Yamaguchi Y, Ishii R, Tokuda T, Miyajima M, Arai H, Kato T, Furukawa K, Arai H, Kikuchi A, Takeda A, Ugawa Y, Hashimoto Y.
    • Journal Title

      J Biochem.

      Volume: 印刷中

    • NAID

      40020914028

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] The trend of developing new disease-modifying drugs in Alzheimer's disease2016

    • Author(s)
      Arai H, Furukawa K, Tomita N, Ishiki A, Okamura N, Kudo Y.
    • Journal Title

      Nihon Rinsho.

      Volume: 74 Pages: 411-416

    • NAID

      40020797227

    • Related Report
      2015 Research-status Report
  • [Journal Article] Introduction and overview of the special issue "Brain imaging and aging": The new era of neuroimaging in aging research.2016

    • Author(s)
      Furukawa K, Ishiki A, Tomita N, Onaka Y, Saito H, Nakamichi T, Hara K, Kusano Y, Ebara M, Arata Y, Sakota M, Miyazawa I, Totsune T, Okinaga S, Okamura N, Kudo Y, Arai H.
    • Journal Title

      Ageing Res Rev

      Volume: - Pages: 1-3

    • DOI

      10.1016/j.arr.2016.02.005

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Advances in the development of tau PET radiotracers and their clinical applications.2016

    • Author(s)
      Okamura N, Harada R, Furukawa K, Furumoto S, Tago T, Yanai K, Arai H, Kudo Y.
    • Journal Title

      Ageing Res Rev.

      Volume: - Pages: 107-113

    • DOI

      10.1016/j.arr.2015.12.010

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Randomized double-blind placebo-controlled multicenter trial of Yokukansan for neuropsychiatric symptoms in Alzheimer's disease.2016

    • Author(s)
      K.Furukawa,N.Tomita,D.Uematsu, K. Okahara, H.Shimada,
    • Journal Title

      Geriatr Gerontol Int.

      Volume: 印刷中 Issue: 2 Pages: 1-8

    • DOI

      10.1111/ggi.12696

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 18F-THK5351: A Novel PET Radiotracer for Imaging Neurofibrillary Pathology in Alzheimer Disease2016

    • Author(s)
      Harada R, Okamura N, Furumoto S, Furukawa K, Ishiki A, Tomita N, Tago T, Hiraoka K, Watanuki S, Shidahara M, Miyake M, Ishikawa Y, Matsuda R, Inami A, Yoshikawa T, Funaki Y, Iwata R, Tashiro M, Yanai K, Arai H, Kudo Y
    • Journal Title

      J Nucl Med

      Volume: 57 Issue: 2 Pages: 208-214

    • DOI

      10.2967/jnumed.115.164848

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Longitudinal Assessment of Tau Pathology in Patients with Alzheimer's Disease Using [18F]THK-5117 Positron Emission Tomography2015

    • Author(s)
      Ishiki, Aiko Okamura, Nobuyuki Furukawa, Katsutoshi Furumoto, Shozo Harada, Ryuichi Tomita, Naoki Hiraoka, Kotaro Watanuki, Shoichi Ishikawa, Yoichi Tago, Tetsuro Funaki, Yoshihito Iwata, Ren Tashiro, Manabu Yanai, Kazuhiko Kudo, Yukitsuka Arai, Hiroyuki
    • Journal Title

      PLoS One

      Volume: 10 Issue: 10 Pages: 1-9

    • DOI

      10.1371/journal.pone.0140311

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Amyloid deposits and response to shunt surgery in idiopathic normal-pressure hydrocephalus2015

    • Author(s)
      Hiraoka, Kotaro Narita, Wataru Kikuchi, Hirokazu Baba, Toru Kanno, Shigenori Iizuka, Osamu Tashiro, Manabu Furumoto, Shozo Okamura, Nobuyuki Furukawa, Katsutoshi Arai, Hiroyuki Iwata, Ren Mori, Etsuro Yanai, Kazuhiko
    • Journal Title

      J Neurol Sci

      Volume: 356 Issue: 1-2 Pages: 124-128

    • DOI

      10.1016/j.jns.2015.06.029

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Quantitative kinetic analysis of PET amyloid imaging agents [(11)C]BF227 and [(18)F]FACT in human brain.2015

    • Author(s)
      Shidahara M, Watabe H, Tashiro M, Okamura N, Furumoto S, Watanuki S, Furukawa K, Arakawa Y, Funaki Y, Iwata R, Gonda K, Kudo Y, Arai H, Ishiwata K, Yanai K.
    • Journal Title

      Nucl Med Biol.

      Volume: 42 Issue: 9 Pages: 734-744

    • DOI

      10.1016/j.nucmedbio.2015.05.001

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Cortical laminar binding of PET amyloid and tau tracers in Alzheimer disease.2015

    • Author(s)
      Li Y, Furukawa K, et al.
    • Journal Title

      J Nucl Med

      Volume: 56 Issue: 2 Pages: 270-273

    • DOI

      10.2967/jnumed.114.149229

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] [18F]THK-5117 PET for assessing neurofibrillary pathology in Alzheimer's disease.2014

    • Author(s)
      Harada R, Furukawa K, et al.
    • Journal Title

      Eur J Nucl Med Mol Imaging

      Volume: 42 Issue: 7 Pages: 1052-1061

    • DOI

      10.1007/s00259-015-3035-4

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] 進行性核上性麻痺におけるタウPETトレーサー[18F]THK-5351画像2015

    • Author(s)
      石木愛子、原田龍一、冨田尚希、岡村信行、古川勝敏、工藤幸司、荒井啓行
    • Organizer
      日本認知症学会学術集会
    • Place of Presentation
      リンクステーションホール青森(青森県・青森市)
    • Year and Date
      2015-10-02
    • Related Report
      2015 Research-status Report
  • [Presentation] 軽度認知障害、アルツハイマー病患者におけるタウPETプローブ[18F]THK-5351の臨床評価2015

    • Author(s)
      大宮佳奈子、岡村信行、原田龍一、古本祥三、古川勝敏、石木愛子、田代学、荒井啓行、谷内一彦、工藤幸司
    • Organizer
      日本認知症学会学術集会
    • Place of Presentation
      リンクステーションホール青森(青森県・青森市)
    • Year and Date
      2015-10-02
    • Related Report
      2015 Research-status Report
  • [Presentation] タウPETプローブ[18F]THK-5351の結合特異性の解析2015

    • Author(s)
      原田龍一、岡村信行、古本祥三、古川勝敏、石木愛子、岩田錬、谷内一彦、荒井啓行、工藤幸司
    • Organizer
      日本認知症学会学術集会
    • Place of Presentation
      リンクステーションホール青森(青森県・青森市)
    • Year and Date
      2015-10-02
    • Related Report
      2015 Research-status Report
  • [Presentation] Tau imaging with PET in Tohoku University2015

    • Author(s)
      古川 勝敏、原田龍一、石木愛子、冨田尚希、古本祥三、岡村信行、田代学、谷内一彦、荒井啓行、工藤幸司
    • Organizer
      日本認知症学会学術集会
    • Place of Presentation
      リンクステーションホール青森(青森県・青森市)
    • Year and Date
      2015-10-02
    • Related Report
      2015 Research-status Report
  • [Presentation] Tau Positron Emission Tomography Images with a Novel Tracer, 18F-THK5351, in a Patient with Progressive Supranuclear Palsy.2015

    • Author(s)
      Aiko Ishiki, Ryuichi Harada, Naoki Tomita, Nobuyuki Okamura, Katsutoshi Furukawa, Yukitsuka Kudo, Hiroyuki Arai.
    • Organizer
      Alzheimer's Association International Conference
    • Place of Presentation
      ワシントンDC (米国)
    • Year and Date
      2015-07-18
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Distribution of Tau Pathology in the Patients with Mild Cognitive Impairment and Alzheimer’s Disease Measured with [18f]Thk-5351 PET.2015

    • Author(s)
      Nobuyuki Okamura, Shozo Furumoto, Katsutoshi Furukawa, Aiko Ishiki, Naoki Tomita, Ryuichi Harada, Manabu Tashiro, Kazuhiko Yanai, Hiroyuki Arai, Yukitsuka Kudo
    • Organizer
      Alzheimer's Association International Conference
    • Place of Presentation
      ワシントンDC (米国)
    • Year and Date
      2015-07-18
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Validation of the Binding Specificity of Tau PET Tracer [18f]Thk-5351 on Postmortem Human Brain Samples2015

    • Author(s)
      Ryuichi Harada, Nobuyuki Okamura, Shozo Furumoto, Katsutoshi Furukawa, Aiko Ishiki, Naoki Tomita, Tetsuro Tago, Ren Iwata, Kazuhiko Yanai, Hiroyuki Arai, Yukitsuka Kudo
    • Organizer
      Alzheimer's Association International Conference
    • Place of Presentation
      ワシントンDC (米国)
    • Year and Date
      2015-07-18
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research

URL: 

Published: 2015-04-16   Modified: 2018-03-22  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi