| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
In any of the amyloidgenic disorders, it is surmised that the monomer of the amyloid protein itself is not very toxic, while misfolded oligomers could cause damage to organs. It is, therefore, truly important to detect the accumulation of real amyloid fibrils for early and accurate diagnosis of amyloidosis. In order to visualize amyloid deposition, the patients with amyloidosis (Alzheimer's disease, rheumatoid arthritis, multiple myeloma, etc) underwent a positron emission tomography (PET) study with a amyloid specific PET tracer, [11C]-BF227. The PET images revealed significantly robust retention of [11C]-BF227 in the patients with amyloidosis compared to that of the normal control. To our knowledge, this is the first report showing the usefulness of a beta-pleated sheet structure-specific PET in investing visceral organ amyloidosis. Therefore, we will be continuing the effort to improve this PET technology with BF227 for the diagnosis of amyloidosis.
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