Establishment of a diagnostic method of amyloidosis with PET

• Project/Area Number: 15K15268
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: General internal medicine(including psychosomatic medicine)
• Research Institution: Tohoku Medical and Pharmaceutical University (2016); Tohoku University (2015)
• Principal Investigator: FURUKAWA Katsutoshi 東北医科薬科大学, 医学部, 教授 (30241631)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: アミロイドーシス / PET / アミロイド / アルツハイマー病

Outline of Final Research Achievements

In any of the amyloidgenic disorders, it is surmised that the monomer of the amyloid protein itself is not very toxic, while misfolded oligomers could cause damage to organs. It is, therefore, truly important to detect the accumulation of real amyloid fibrils for early and accurate diagnosis of amyloidosis. In order to visualize amyloid deposition, the patients with amyloidosis (Alzheimer's disease, rheumatoid arthritis, multiple myeloma, etc) underwent a positron emission tomography (PET) study with a amyloid specific PET tracer, [11C]-BF227. The PET images revealed significantly robust retention of [11C]-BF227 in the patients with amyloidosis compared to that of the normal control. To our knowledge, this is the first report showing the usefulness of a beta-pleated sheet structure-specific PET in investing visceral organ amyloidosis. Therefore, we will be continuing the effort to improve this PET technology with BF227 for the diagnosis of amyloidosis.

Research Products

• [Journal Article] Accurate quantitation of choline and ethanolamine plasmalogen molecular species in human plasma by liquid chromatography-tandem mass spectrometry. (2017)
  • Author(s): Otoki Y et al.
  • Journal Title: J Pharm Biomed Anal. Volume: 134 Pages: 77-85
  • DOI: 10.1016/j.jpba.2016.11.019
  • Peer Reviewed
• [Journal Article] Tau imaging with [18F]THK-5351 in progressive supranuclear palsy. (2017)
  • Author(s): Ishiki A, Harada R, Okamura N, Tomita N, Rowe CC, Villemagne VL, Yanai K, Kudo Y, Arai H, Furumoto S, Tashiro M, Furukawa K.
  • Journal Title: Eur J Neurol. Volume: 24 Issue: 1 Pages: 130-136
  • DOI: 10.1111/ene.13164
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Subgroup differences in 'brain-type' transferrin and α-synuclein in Parkinson's disease and multiple system atrophy. (2016)
  • Author(s): Yoshihara A, Fukatsu M, Hoshi K, Ito H, Nollet K, Yamaguchi Y, Ishii R, Tokuda T, Miyajima M, Arai H, Kato T, Furukawa K, Arai H, Kikuchi A, Takeda A, Ugawa Y, Hashimoto Y.
  • Journal Title: J Biochem. Volume: 印刷中
  • NAID: 40020914028
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] The trend of developing new disease-modifying drugs in Alzheimer's disease (2016)
  • Author(s): Arai H, Furukawa K, Tomita N, Ishiki A, Okamura N, Kudo Y.
  • Journal Title: Nihon Rinsho. Volume: 74 Pages: 411-416
  • NAID: 40020797227
• [Journal Article] Introduction and overview of the special issue "Brain imaging and aging": The new era of neuroimaging in aging research. (2016)
  • Author(s): Furukawa K, Ishiki A, Tomita N, Onaka Y, Saito H, Nakamichi T, Hara K, Kusano Y, Ebara M, Arata Y, Sakota M, Miyazawa I, Totsune T, Okinaga S, Okamura N, Kudo Y, Arai H.
  • Journal Title: Ageing Res Rev Volume: - Pages: 1-3
  • DOI: 10.1016/j.arr.2016.02.005
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Advances in the development of tau PET radiotracers and their clinical applications. (2016)
  • Author(s): Okamura N, Harada R, Furukawa K, Furumoto S, Tago T, Yanai K, Arai H, Kudo Y.
  • Journal Title: Ageing Res Rev. Volume: - Pages: 107-113
  • DOI: 10.1016/j.arr.2015.12.010
  • Peer Reviewed
• [Journal Article] Randomized double-blind placebo-controlled multicenter trial of Yokukansan for neuropsychiatric symptoms in Alzheimer's disease. (2016)
  • Author(s): K.Furukawa,N.Tomita,D.Uematsu, K. Okahara, H.Shimada,
  • Journal Title: Geriatr Gerontol Int. Volume: 印刷中 Issue: 2 Pages: 1-8
  • DOI: 10.1111/ggi.12696
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] 18F-THK5351: A Novel PET Radiotracer for Imaging Neurofibrillary Pathology in Alzheimer Disease (2016)
  • Author(s): Harada R, Okamura N, Furumoto S, Furukawa K, Ishiki A, Tomita N, Tago T, Hiraoka K, Watanuki S, Shidahara M, Miyake M, Ishikawa Y, Matsuda R, Inami A, Yoshikawa T, Funaki Y, Iwata R, Tashiro M, Yanai K, Arai H, Kudo Y
  • Journal Title: J Nucl Med Volume: 57 Issue: 2 Pages: 208-214
  • DOI: 10.2967/jnumed.115.164848
  • Peer Reviewed
• [Journal Article] Longitudinal Assessment of Tau Pathology in Patients with Alzheimer's Disease Using [18F]THK-5117 Positron Emission Tomography (2015)
  • Author(s): Ishiki, Aiko Okamura, Nobuyuki Furukawa, Katsutoshi Furumoto, Shozo Harada, Ryuichi Tomita, Naoki Hiraoka, Kotaro Watanuki, Shoichi Ishikawa, Yoichi Tago, Tetsuro Funaki, Yoshihito Iwata, Ren Tashiro, Manabu Yanai, Kazuhiko Kudo, Yukitsuka Arai, Hiroyuki
  • Journal Title: PLoS One Volume: 10 Issue: 10 Pages: 1-9
  • DOI: 10.1371/journal.pone.0140311
  • Peer Reviewed / Open Access
• [Journal Article] Amyloid deposits and response to shunt surgery in idiopathic normal-pressure hydrocephalus (2015)
  • Author(s): Hiraoka, Kotaro Narita, Wataru Kikuchi, Hirokazu Baba, Toru Kanno, Shigenori Iizuka, Osamu Tashiro, Manabu Furumoto, Shozo Okamura, Nobuyuki Furukawa, Katsutoshi Arai, Hiroyuki Iwata, Ren Mori, Etsuro Yanai, Kazuhiko
  • Journal Title: J Neurol Sci Volume: 356 Issue: 1-2 Pages: 124-128
  • DOI: 10.1016/j.jns.2015.06.029
  • Peer Reviewed
• [Journal Article] Quantitative kinetic analysis of PET amyloid imaging agents [(11)C]BF227 and [(18)F]FACT in human brain. (2015)
  • Author(s): Shidahara M, Watabe H, Tashiro M, Okamura N, Furumoto S, Watanuki S, Furukawa K, Arakawa Y, Funaki Y, Iwata R, Gonda K, Kudo Y, Arai H, Ishiwata K, Yanai K.
  • Journal Title: Nucl Med Biol. Volume: 42 Issue: 9 Pages: 734-744
  • DOI: 10.1016/j.nucmedbio.2015.05.001
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Cortical laminar binding of PET amyloid and tau tracers in Alzheimer disease. (2015)
  • Author(s): Li Y, Furukawa K, et al.
  • Journal Title: J Nucl Med Volume: 56 Issue: 2 Pages: 270-273
  • DOI: 10.2967/jnumed.114.149229
  • Peer Reviewed
• [Journal Article] [18F]THK-5117 PET for assessing neurofibrillary pathology in Alzheimer's disease. (2014)
  • Author(s): Harada R, Furukawa K, et al.
  • Journal Title: Eur J Nucl Med Mol Imaging Volume: 42 Issue: 7 Pages: 1052-1061
  • DOI: 10.1007/s00259-015-3035-4
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] 進行性核上性麻痺におけるタウPETトレーサー[18F]THK-5351画像 (2015)
  • Author(s): 石木愛子、原田龍一、冨田尚希、岡村信行、古川勝敏、工藤幸司、荒井啓行
  • Organizer: 日本認知症学会学術集会
  • Place of Presentation: リンクステーションホール青森(青森県・青森市)
  • Year and Date: 2015-10-02
• [Presentation] 軽度認知障害、アルツハイマー病患者におけるタウPETプローブ[18F]THK-5351の臨床評価 (2015)
  • Author(s): 大宮佳奈子、岡村信行、原田龍一、古本祥三、古川勝敏、石木愛子、田代学、荒井啓行、谷内一彦、工藤幸司
  • Organizer: 日本認知症学会学術集会
  • Place of Presentation: リンクステーションホール青森(青森県・青森市)
  • Year and Date: 2015-10-02
• [Presentation] タウPETプローブ[18F]THK-5351の結合特異性の解析 (2015)
  • Author(s): 原田龍一、岡村信行、古本祥三、古川勝敏、石木愛子、岩田錬、谷内一彦、荒井啓行、工藤幸司
  • Organizer: 日本認知症学会学術集会
  • Place of Presentation: リンクステーションホール青森(青森県・青森市)
  • Year and Date: 2015-10-02
• [Presentation] Tau imaging with PET in Tohoku University (2015)
  • Author(s): 古川 勝敏、原田龍一、石木愛子、冨田尚希、古本祥三、岡村信行、田代学、谷内一彦、荒井啓行、工藤幸司
  • Organizer: 日本認知症学会学術集会
  • Place of Presentation: リンクステーションホール青森(青森県・青森市)
  • Year and Date: 2015-10-02
• [Presentation] Tau Positron Emission Tomography Images with a Novel Tracer, 18F-THK5351, in a Patient with Progressive Supranuclear Palsy. (2015)
  • Author(s): Aiko Ishiki, Ryuichi Harada, Naoki Tomita, Nobuyuki Okamura, Katsutoshi Furukawa, Yukitsuka Kudo, Hiroyuki Arai.
  • Organizer: Alzheimer's Association International Conference
  • Place of Presentation: ワシントンDC (米国)
  • Year and Date: 2015-07-18
  • Int'l Joint Research
• [Presentation] Distribution of Tau Pathology in the Patients with Mild Cognitive Impairment and Alzheimer’s Disease Measured with [18f]Thk-5351 PET. (2015)
  • Author(s): Nobuyuki Okamura, Shozo Furumoto, Katsutoshi Furukawa, Aiko Ishiki, Naoki Tomita, Ryuichi Harada, Manabu Tashiro, Kazuhiko Yanai, Hiroyuki Arai, Yukitsuka Kudo
  • Organizer: Alzheimer's Association International Conference
  • Place of Presentation: ワシントンDC (米国)
  • Year and Date: 2015-07-18
  • Int'l Joint Research
• [Presentation] Validation of the Binding Specificity of Tau PET Tracer [18f]Thk-5351 on Postmortem Human Brain Samples (2015)
  • Author(s): Ryuichi Harada, Nobuyuki Okamura, Shozo Furumoto, Katsutoshi Furukawa, Aiko Ishiki, Naoki Tomita, Tetsuro Tago, Ren Iwata, Kazuhiko Yanai, Hiroyuki Arai, Yukitsuka Kudo
  • Organizer: Alzheimer's Association International Conference
  • Place of Presentation: ワシントンDC (米国)
  • Year and Date: 2015-07-18
  • Int'l Joint Research