Investigation of key molecules involved in bidirectional interactions between diabetes and dementia
| Project/Area Number |
15K15272
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
General internal medicine(including psychosomatic medicine)
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| Research Institution | National Center for Geriatrics and Gerontology (2016-2017)
Osaka University (2015) |
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Principal Investigator |
SATO Naoyuki 国立研究開発法人国立長寿医療研究センター, 分子基盤研究部, 部長 (70372612)
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| Co-Investigator(Kenkyū-buntansha) |
長野 清一 国立研究開発法人国立精神・神経医療研究センター, 神経研究所 疾病研究第五部, 室長 (40362727)
竹屋 泰 大阪大学, 医学系研究科, 助教 (70590339)
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| Research Collaborator |
TAKEYA Miyuki
MUKOUZONO Masahiro
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | アルツハイマー病 / 糖尿病 / 遺伝子 / ゲノム編集 / 認知症 / βアミロイド / タウ |
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| Outline of Final Research Achievements |
Alzheimer's disease (AD) is one of the major causes of dementia. In addition to APOE4, non-genetic risk factors such as diabetes have also emerged. However, mechanisms by which diabetes increases AD have not been fully understood. To investigate the interactions between AD and diabetes, we generated a novel model with AD and diabetes by crossing amyloid precursor protein (APP) mice and ob/ob mice. These mice show cognitive dysfunction even in young age. We performed gene expression analysis of APP+ob/ob mice. There are genes upregulated only in APP+ob/ob mice. These genes include 37 genes such as Factor X1, a secreted protein, and Factor X2, a transcriptional factor. We are generating gene knockout mice from the genes with the highest changes. Using these knockout mice, we will assess whether these genes could be targets for novel therapeutics for dementia.
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Report
(4 results)
Research Products
(22 results)
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[Presentation] 糖尿病と認知症2016
Author(s)
里 直行
Organizer
第56回 近畿理学療法学術大会
Place of Presentation
和歌山
Year and Date
2016-11-27
Related Report
Invited
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