In body signals of next generation Lactobaccillus and their clinical application
| Project/Area Number |
15K15274
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
General internal medicine(including psychosomatic medicine)
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| Research Institution | The University of Tokushima |
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Principal Investigator |
ROKUTAN Kazuhito 徳島大学, 大学院医歯薬学研究部(医学系), 教授 (10230898)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 次世代乳酸菌 / ストレス緩和 / 睡眠 / 脳腸軸 / 生体内シグナル |
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| Outline of Final Research Achievements |
The bidirectional communication between the brain and the gut, called “the gut-brain axis”, plays a potential role in the maintenance of the brain function and the gut homeostasis. Recently, orally administered probiotics have been shown to modify the gut-brain axis and control the stress response. We reported that a unique Lactobacillus gasseri strain CP2305 (CP2305) could relieve stress-associated behaviors in healthy young adults and improve clinical symptoms of IBS. This study aimed to reveal the communication between CP2305 and the gut-brain axis. We tested whether heat-killed, washed CP2305 could exert beneficial effects on medical students under chronically stressful conditions. Administration of paraprobiotic CP2305 significantly ameliorated their stress-related adverse behaviours and improved sleep disturbance. Our results suggest that CP2305 may bind a responsible receptor(s) on intestinal epithelial cells and promote the dispatch of a signal(s) driving the HPA axis.
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Report
(3 results)
Research Products
(13 results)
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[Journal Article] Beneficial effects of the probiotic Lactobacillus casei strain Shirota on academic stress-induced sleep disturbance in healthy adults in a double-blind, randomized, placebo-controlled trial2017
Author(s)
Takada M, Nishida K, Gondo Y, Kikuchi-Hayakawa H, Ishikawa H, Suda K, Kawai M, Hoshi R, Kuwano Y, Miyazaki K, Rokutan K
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Journal Title
Benef Microbes
Volume: 8
Pages: 153-162
Related Report
Peer Reviewed
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[Journal Article] Fermented Milk Containing Lactobacillus casei Strain Shirota Preserves the Diversity of the Gut Microbiota and Relieves Abdominal Dysfunction in Healthy Medical Students Exposed to Academic Stress2016
Author(s)
Kato-Kataoka A, Nishida K, Takada M, Kawai M, Kikuchi-Hayakawa H, Suda K, Ishikawa H, Gondo Y, Shimizu K, Matsuki T, Kushiro A, Hoshi R, Watanabe O, Igarashi T, Miyazaki K, Kuwano Y, Rokutan K
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Journal Title
Appl Environ Microbiol
Volume: 82
Issue: 12
Pages: 3649-3658
DOI
Related Report
Peer Reviewed
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[Journal Article] Probiotic Lactobacillus casei strain Shirota relieves stress-associated symptoms by modulating the gut-brain interaction in human and animal models2016
Author(s)
Takada M, Nishida K, Kataoka-Kato A, Gondo Y, Ishikawa H, Suda K, Kawai M, Hoshi R, Watanabe O, Igarashi T, Kuwano Y, Miyazaki K, Rokutan K
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Journal Title
Neurogastroenterol Motil
Volume: 28
Issue: 7
Pages: 1027-1036
DOI
Related Report
Peer Reviewed
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[Journal Article] Fermented milk containing Lactobacillus casei strain Shirota prevents the onset of physical symptoms in medical students under academic examination stress2016
Author(s)
Kato-Kataoka A, Nishida K, Takada M, Suda K, Kawai M, Shimizu K, Kushiro A, Hoshi R, Watanabe O, Igarashi T, Miyazaki K, Kuwano Y, Rokutan K
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Journal Title
Benef Microbes
Volume: 7
Issue: 2
Pages: 153-156
DOI
Related Report
Peer Reviewed
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[Journal Article] Fermented milk containing Lactobacillus casei strain Shirota preserves the diversity of the gut microbiota and relieves abdominal dysfunction in healthy medical students exposed to academic stress2016
Author(s)
Kato-Kataoka A, Nishida K, Takada M, Kawai M, Kikuchi-Hayakawa H, Suda K, Ishikawa H, Gondo Y, Shimizu K, Matsuki T, Kushiro A, Hoshi R, Watanabe O, Igarashi T, Miyazaki K, Kuwano Y, Rokutan K
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Journal Title
Applied and Environmental Microbiology
Volume: in press
Related Report
Peer Reviewed
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