| Project/Area Number |
15K15274
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
General internal medicine(including psychosomatic medicine)
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| Research Institution | The University of Tokushima |
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Principal Investigator |
ROKUTAN Kazuhito 徳島大学, 大学院医歯薬学研究部(医学系), 教授 (10230898)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 次世代乳酸菌 / ストレス緩和 / 睡眠 / 脳腸軸 / 生体内シグナル |
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| Outline of Final Research Achievements |
The bidirectional communication between the brain and the gut, called “the gut-brain axis”, plays a potential role in the maintenance of the brain function and the gut homeostasis. Recently, orally administered probiotics have been shown to modify the gut-brain axis and control the stress response. We reported that a unique Lactobacillus gasseri strain CP2305 (CP2305) could relieve stress-associated behaviors in healthy young adults and improve clinical symptoms of IBS. This study aimed to reveal the communication between CP2305 and the gut-brain axis. We tested whether heat-killed, washed CP2305 could exert beneficial effects on medical students under chronically stressful conditions. Administration of paraprobiotic CP2305 significantly ameliorated their stress-related adverse behaviours and improved sleep disturbance. Our results suggest that CP2305 may bind a responsible receptor(s) on intestinal epithelial cells and promote the dispatch of a signal(s) driving the HPA axis.
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