How do short-chain fatty acid affect host behaviors?
| Project/Area Number |
15K15276
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
General internal medicine(including psychosomatic medicine)
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
吉原 一文 九州大学, 大学病院, 講師 (20444854)
須藤 信行 九州大学, 医学研究院, 教授 (60304812)
波夛 伴和 九州大学, 大学病院, 助教 (10535983)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 短鎖脂肪酸 / 食物繊維 / 腸内細菌 / 行動特性 / 脳腸相関 / 行動解析 / アイソレーター |
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| Outline of Final Research Achievements |
In this study, we used the diet containing acetylated, propionylated or butyrylated starches in order to increase the level of short-chain fatty acids (SCFA) in the intestinal lumen. As a result, the diet was good for the growth of mice and resulted in the creation of SCFA such as acetic acid, propionic acid or butyric acid in the cecum. We fed SPF mice with the diet and investigated physiological function. However, no definite behavior change was found between the mice group which did have SCFA containing diet and did not. In conclusion, this diet is considered to be useful for elucidating the mechanism by which SCFA derived from gut microbe affect host physiology.
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Report
(3 results)
Research Products
(11 results)
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[Journal Article] QseC inhibition as an antivirulence approach for colitis-associated bacteria.2017
Author(s)
Rooks MG, Veiga P, Reeves AZ, Lavoie S, Yasuda K, Asano Y, Yoshihara K, Michaud M, Wardwell-Scott L, Gallini CA, Glickman JN, Sudo N, Huttenhower C, Lesser CF, Garrett WS.
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Journal Title
Proc Natl Acad Sci U S A
Volume: 3;114(1)
Issue: 1
Pages: 142-147
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Age-associated effect of kestose on Faecalibacterium prausnitzii and symptoms in the atopic dermatitis infants.2016
Author(s)
Koga Y, Tokunaga S, Nagano J, Sato F, Konishi K, Tochio T, Murakami Y, Masumoto N, Tezuka JI, Sudo N, Kubo C, Shibata R.
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Journal Title
Pediatr Res
Volume: 80(6)
Issue: 6
Pages: 844-851
DOI
Related Report
Peer Reviewed / Open Access
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