| Project/Area Number |
15K15283
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
General internal medicine(including psychosomatic medicine)
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| Research Institution | National Center of Neurology and Psychiatry |
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Principal Investigator |
Honda Manabu 国立研究開発法人国立精神・神経医療研究センター, 神経研究所 疾病研究第七部, 部長 (40321608)
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| Co-Investigator(Renkei-kenkyūsha) |
YAMASHITA Yuichi 国立研究開発法人 国立精神・神経医療研究センター, 神経研究所 疾病研究第七部, 室長 (40584131)
UENO Osamu 国立研究開発法人 国立精神・神経医療研究センター, 神経研究所 疾病研究第七部, 研究員 (90261130)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 脳神経疾患 / トランスレーショナルリサーチ / 神経科学 / 脳・神経 / 情報環境 |
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| Outline of Final Research Achievements |
In order to explore underlying biological mechanism of acoustic enrichment therapy which we are developing, we examined the effects of enrichment of acoustic environment on lifespan and voluntary movements in mice. Mice were assigned to two groups with different acoustic environments throughout the experiment: (1) acoustically enriched environment with sounds of tropical rain forest (AEE group), and (2) standard environment without any exposure to stimulation (CNT group). The mice of AEE group lived significantly longer than those of CNT group. In addition, the voluntary movements of AEE group significantly increased compared to those of CNT group. However, no correlation between the lifespan and voluntary movements was observed. The results showed that additional acoustic stimuli with standard rearing condition prolonged natural lifespan of the mice.
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