| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
To see the interaction between the genetic background and gut microbiota in Japanese patients with inflammatory bowel disease (IBD), we investigated the ‘typical’ signature of genetics and microbiota of IBD. The genetic background was known to be associated with IBD, but we found that it was associated with abnormal Paneth cells in Japanese CD. We also investigated the gut microbiota from 16 Japanese patients with ulcerative colitis, the diversity of microbiota was significantly different between the involved region and non-involved region even in the same patient. From the above, further analysis will be needed to prepare the model to see the gene-environmental interaction in IBD.
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