Gene-microbiota interaction of inflammatory bowel disease
Project/Area Number |
15K15284
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Gastroenterology
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Research Institution | Tohoku University |
Principal Investigator |
|
Project Period (FY) |
2015-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | 炎症性腸疾患 / 腸内細菌叢 / 疾患感受性遺伝子 |
Outline of Final Research Achievements |
To see the interaction between the genetic background and gut microbiota in Japanese patients with inflammatory bowel disease (IBD), we investigated the ‘typical’ signature of genetics and microbiota of IBD. The genetic background was known to be associated with IBD, but we found that it was associated with abnormal Paneth cells in Japanese CD. We also investigated the gut microbiota from 16 Japanese patients with ulcerative colitis, the diversity of microbiota was significantly different between the involved region and non-involved region even in the same patient. From the above, further analysis will be needed to prepare the model to see the gene-environmental interaction in IBD.
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Report
(3 results)
Research Products
(3 results)
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[Journal Article] LRRK2 but not ATG16L1 is associated with Paneth cell defect in Japanese Crohn's disease patients2017
Author(s)
Liu TC, Naito T, Liu Z, VanDussen KL, Haritunians T, Li D, Endo K, Kawai Y, Nagasaki M, Kinouchi Y, McGovern DP, Shimosegawa T, Kakuta Y, Stappenbeck TS
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Journal Title
JCI Insight
Volume: 印刷中
Issue: 6
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Presentation] Paneth Cell Phenotype is Associated with Novel Genetic Determinants and Clinical Outcome in Japanese Crohn's Disease Patients2016
Author(s)
Takeo Naito, Ta-Chiang Liu, Yoichi Kakuta, Richard Head, Zhenqiu Liu, Talin Haritunians, Dalin Li, Katsuya Endo, Yoshitaka Kinouchi, Dermot P.B. McGovern, Thaddeus S. Stappenbeck, Tooru Shimosegawa
Organizer
Digestive Disease Week 2016
Place of Presentation
San Diego, USA
Related Report
Int'l Joint Research