The role of Helicobacter Pylori in heart failure and effect of eradiation of Helicobacter Pylori
| Project/Area Number |
15K15302
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cardiovascular medicine
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| Research Institution | Hokkaido University |
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Principal Investigator |
Tsutsui Hiroyuki 北海道大学, 医学(系)研究科(研究院), 教授 (70264017)
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| Co-Investigator(Kenkyū-buntansha) |
絹川 真太郎 北海道大学, 医学研究科, 講師 (60399871)
松島 将士 九州大学, 大学病院, 助教 (80552869)
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| Co-Investigator(Renkei-kenkyūsha) |
KINUKAWA Shintaro 北海道大学, 大学院医学研究科, 講師 (60399871)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 心不全 / 心筋リモデリング / ヘリコバクターピロリ / 感染 / 心機能 |
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| Outline of Final Research Achievements |
To elucidate the incidence rate of Helicobacter Pylori (HP) infection, serum HP antibody level in 152 patients with chronic heart failure (CHF) (107 men, 45 women, Age 64.6±14.4 y.o., LVEF 41.4±15.7%) and 32 control subjects (28 men, 4 women, Age 52.4±8.6 y.o., LVEF 61.4±6.0%) was investigated (cut-off point of the test for the diagnosis of Hp infection:10U/ml). The incident rate of HP infection in CHF was significantly higher than that in control subjects (49% v.s. 28%, P<0.05). CHF patients and control subjects among 50 to 69 year olds were investigated. The incident rate of HP infection in CHF was significantly higher than that in control subjects among 50 to 69 year olds (57% v.s. 29%, P<0.05). CHF with HP infection showed greater LV end-diastolic dimension (LVDd) than those without HP infection. Multivariate analysis demonstrated that age, history of atrial fibrillation, triglyceride, and LVDd were independently related to HP infection.
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Report
(3 results)
Research Products
(13 results)
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[Journal Article] Heart Rate Control With If Inhibitor, Ivabradine, in Japanese Patients With Chronic Heart Failure - A Randomized, Double-Blind, Placebo-Controlled Phase II Study.2016
Author(s)
Tsutsui H, Momomura S, Yamashina A, Ogawa H, Shimokawa H, Kihara Y, Saito Y, Hagiwara N, Ito H, Ako J, Inomata T, Tanaka T, Kawasaki Y; study investigators.
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Journal Title
Circ J.
Volume: 80(3)
Pages: 668-76
NAID
Related Report
Peer Reviewed
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[Journal Article] Myocardial shortening in 3 orthogonal directions and its transmural variation in patients with nonobstructive hypertrophic cardiomyopathy.2015
Author(s)
Okada K, Yamada S, Iwano H, Nishino H, Nakabachi M, Yokoyama S, Abe A, Ichikawa A, Kaga S, Nishida M, Hayashi T, Murai D, Mikami T, Tsutsui H.
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Journal Title
Circ J.
Volume: 79(11)
Pages: 2471-9
NAID
Related Report
Peer Reviewed
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[Journal Article] Serum brain-derived neurotrophic factor level predicts adverse clinical outcomes in patients with heart failure.2015
Author(s)
Fukushima A, Kinugawa S, Homma T, Masaki Y, Furihata T, Yokota T, Matsushima S, Takada S, Kadoguchi T, Oba K, Okita K, Tsutsui H
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Journal Title
J Card Fail.
Volume: 21(4)
Pages: 300-306
Related Report
Peer Reviewed
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