Estimation of the role of age-associated factors by using experimental aging models

• Project/Area Number: 15K15306
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Cardiovascular medicine
• Research Institution: Niigata University
• Principal Investigator: MINAMINO TOHRU 新潟大学, 医歯学系, 教授 (90328063)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 細胞老化 / 生活習慣病

Outline of Final Research Achievements

Accumulation of senescent vascular endothelial cells impairs the vessel homeostasis and promotes atherosclerotic diseases, however, underlying mechanisms are largely unknown. We identified a novel protein, senescence-associated glycoprotein (SAGP), as a biomarker of endothelial cell senescence. We found that SAGP expression was significantly increased in HUVECs undergoing replicative senescence. SAGP expression was significantly higher in patients with atherosclerotic diseases compared to patients without atherosclerotic diseases. Deletion of SAGP in HUVECs resulted in high mitochondrial ROS level and promoted premature senescence in these cells. The fragmented mitochondria were increased and mitophagy was decreased in SAGP knockdown HUVECs. Our studies suggest that SAGP is critically involved in the maintenance of vascular homeostasis by the suppression of mitochondrial ROS.

Research Products

• [Journal Article] Progerin impairs vascular smooth muscle cell growth via the DNA damage response pathway. (2017)
  • Author(s): Kinoshita D, Nagasawa A, Shimizu I, Ito T, Yohko Y, Tsuchida M, Iwama A, Hayano T and Minamino T.
  • Journal Title: Oncotarget Volume: 印刷中 Issue: 21 Pages: 34045-34056
  • DOI: 10.18632/oncotarget.15973
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Clinical features and predictors of patients with critical limb ischemia who responded to autologous mononuclear cell transplantation for therapeutic angiogenesis. (2017)
  • Author(s): Aoyama N, Nishinari M, Ohtani S, Kanai A, Noda C, Hirata M, Miyamoto A, Watanabe M, Minamino T, Izumi T, Ako J.
  • Journal Title: Heart Vessels. Volume: 印刷中 Issue: 9 Pages: 1099-1108
  • DOI: 10.1007/s00380-017-0968-5
  • Peer Reviewed / Open Access
• [Journal Article] Quantitative analysis of PKP2 and neighbouring genes in a patient with arrhythmogenic right ventricular cardiomyopathy caused by heterozygous PKP2 deletion. (2017)
  • Author(s): Sonoda K, Ohno S, Otuki S, Kato K, Yagihara N, Watanabe H, Makiyama T, Minamino T, Horie M.
  • Journal Title: Europace. Volume: 19 Pages: 644-650
  • Peer Reviewed / Open Access
• [Journal Article] Inappropriate inhibition of biventricular pacing due to diaphragmatic myopotentials amplified by the selectable sensing filter. (2017)
  • Author(s): Iijima K, Ishida N, Izumi D, Minamino T.
  • Journal Title: Europace. Volume: 印刷中 Issue: 12 Pages: 2014-2014
  • DOI: 10.1093/europace/euw372
  • Peer Reviewed / Open Access
• [Journal Article] Manifestation of Latent Left Ventricular Outflow Tract Obstruction in the Acute Phase of Takotsubo Cardiomyopathy. (2016)
  • Author(s): Otuki S, Hasegawa K, Watanabe H, Katsuumi G, Yagihara N, Iijima K, Sato A, Izumi D, Furushima H,Chinushi M,Aizawa Y, and Minamino T.
  • Journal Title: Journal of Electrocardiology, Volume: - Issue: 3 Pages: 277-281
  • DOI: 10.1016/j.jelectrocard.2016.09.005
  • NAID: 130005171736
  • Peer Reviewed / Open Access
• [Journal Article] Rare Variants in <i>ANK2</i> Associated With Various Inherited Arrhythmia Syndromes (2016)
  • Author(s): Watanabe H, Minamino T.
  • Journal Title: Circulation Journal Volume: 80 Issue: 12 Pages: 2423-2424
  • DOI: 10.1253/circj.CJ-16-1085
  • NAID: 130005285045
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access
• [Journal Article] Manifestation of Latent Left Ventricular Outflow Tract Obstruction in the Acute Phase of Takotsubo Cardiomyopathy (2016)
  • Author(s): Ozaki K, Okubo T, Tanaka K, Hosaka Y, Tsuchida K, Takahashi K, Oda H, Minamino T.
  • Journal Title: Internal Medicine Volume: 55 Issue: 23 Pages: 3413-3420
  • DOI: 10.2169/internalmedicine.55.7119
  • NAID: 130005171736
  • ISSN: 0918-2918, 1349-7235
  • Peer Reviewed / Open Access
• [Journal Article] Early repolarization and risk of arrhythmia events in long QT syndrome. (2016)
  • Author(s): Hasegawa K, Watanabe H, Hisamatsu T, Ohno S, Itoh H, Ashihara T, Hayashi H, Makiyama T, Minamino T, Horie M.
  • Journal Title: Int J Cardiol. Volume: 223 Pages: 540-542
  • DOI: 10.1016/j.ijcard.2016.08.215
  • Peer Reviewed / Open Access
• [Journal Article] Failing Left Ventricles Have an Enhanced Post-Stimulation Potentiation Despite Their Impaired Force Frequency Relationship (2016)
  • Author(s): Watanabe T, *Kashimura T, Kodama M, Tanaka K, Fujiki S, Hayashi Y, Obata H, Hanawa H, Minamino T.
  • Journal Title: International Heart Journal Volume: 57 Issue: 3 Pages: 317-322
  • DOI: 10.1536/ihj.15-374
  • NAID: 130005153698
  • ISSN: 1349-2365, 1349-3299
  • Peer Reviewed / Open Access
• [Journal Article] The first reported case of a transvenous left ventricular pacing lead of cardiac resynchronization therapy causing aggravation of coronary atherosclerosis. (2016)
  • Author(s): *Sato A, Hasegawa Y, Minamino T.
  • Journal Title: Europace. Volume: 18 Issue: 11 Pages: 1734-1734
  • DOI: 10.1093/europace/euw097
  • Peer Reviewed / Open Access
• [Journal Article] Efficacy and Safety of a Novel Endothelin Receptor Antagonist, Macitentan, in Japanese Patients With Pulmonary Arterial Hypertension (2016)
  • Author(s): Tahara N, Dobashi H, Fukuda K, Funauchi M, Hatano M, Ikeda S, Joho S, Kihara Y, Kimura T, Kondo T, Matsushita M, Minamino T, Nakanishi N, Ozaki Y, Saji T, Sakai S, Tanabe N, Watanabe H, Yamada H, Yoshioka K, Sasayama S
  • Journal Title: Circulation Journal Volume: 80 Issue: 6 Pages: 1478-1483
  • DOI: 10.1253/circj.CJ-15-1305
  • NAID: 130005153579
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Quantitative Analysis of PKP2 and Neighboring Genes in a Patient with Arrhythmogenic Right Ventricular Cardiomyopathy Caused by Heterozygous PKP2 Deletion. (2016)
  • Author(s): Sonoda K, Ohno S, Horie M, et al.
  • Journal Title: Europace Volume: 未定 Pages: 644-650
  • DOI: 10.1093/europace/euw038
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Physiological and pathological cardiac hypertrophy. (2016)
  • Author(s): Shimizu I, Minamino T
  • Journal Title: J Mol Cell Cardiol. Volume: 97 Pages: 245-262
  • DOI: 10.1016/j.yjmcc.2016.06.001
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Genetics of Brugada syndrome. (2016)
  • Author(s): Watanabe H, Minamino T
  • Journal Title: Journal of Human Genetics Volume: 61 Issue: 1 Pages: 57-60
  • DOI: 10.1038/jhg.2015.97
  • Peer Reviewed / Open Access
• [Journal Article] A role for circadian clock in metabolic disease.， (2016)
  • Author(s): Shimizu I, Yoshida Y, Minamino T
  • Journal Title: Hypertens Res Volume: Epub ahead of print Issue: 7 Pages: 483-91
  • DOI: 10.1038/hr.2016.12
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] High Frequency of Early Repolarization and Brugada-Type Electrocardiograms in Hypercalcemia. (2016)
  • Author(s): Sonoda K, Watanabe H, Hisamatsu T, Ashihara T, et al.
  • Journal Title: Ann Noninvasive Electrocardiol. Volume: 21 Issue: 1 Pages: 30-40
  • DOI: 10.1111/anec.12303
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Pathological Role of Adipose Tissue Dysfunction in Cardio-Metabolic Disorders. (2015)
  • Author(s): Shimizu I, Yoshida Y, Minamino T.
  • Journal Title: Int Heart J Volume: 56 Pages: 255-9
  • NAID: 130005070025
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Maintenance of Subcutaneous Fat Homeostasis Improves Systemic Metabolic Dysfunction in Obesity. (2015)
  • Author(s): Shimizu I, Yoshida Y, Minamino T.
  • Journal Title: Diabetes Volume: 64 Issue: 12 Pages: 3984-6
  • DOI: 10.2337/dbi15-0013
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Complement C1q-induced activation of β-catenin signalling causes hypertensive arterial remodelling. (2015)
  • Author(s): Sumida T, Naito AT, Nomura S, Nakagawa A, Higo T, Hashimoto A, Okada K, Sakai T, Ito M, Yamaguchi T, Oka T, Akazawa H, Lee JK, Minamino T, Offermanns S, Noda T, Botto M, Kobayashi Y, Morita H, Manabe I, Nagai T, Shiojima I, Komuro I.
  • Journal Title: Nat Commun Volume: 6 Issue: 1 Pages: 6241-6241
  • DOI: 10.1038/ncomms7241
  • Peer Reviewed / Open Access
• [Journal Article] Electrocardiographic abnormalities and risk of developing cardiac events in extracardiac sarcoidosis. (2015)
  • Author(s): Nagao S, Watanabe H, Sobue Y, Kodama M, Tanaka J, Tanabe N, Suzuki E, Narita I, Watanabe E, Aizawa Y, Minamino T.
  • Journal Title: Int J Cardiol Volume: 189 Pages: 1-5
  • DOI: 10.1016/j.ijcard.2015.03.175
  • Peer Reviewed / Open Access
• [Journal Article] Liver Congestion in Heart Failure Contributes to Inappropriately Increased Serum Hepcidin despite Anemia (2015)
  • Author(s): Ohno Y, Hanawa H, Jiao S, Hayashi Y, Yoshida K, Suzuki T, Kashimura T, Obata H, Tanaka K, Watanabe T, Minamino T.
  • Journal Title: The Tohoku Journal of Experimental Medicine Volume: 235 Issue: 1 Pages: 69-79
  • DOI: 10.1620/tjem.235.69
  • NAID: 130004822430
  • ISSN: 0040-8727, 1349-3329
  • Peer Reviewed / Open Access
• [Journal Article] Characteristics of neoplastic cardiac tamponade and prognosis after pericardiocentesis: a single-center study of 113 consecutive cancer patients. (2015)
  • Author(s): Takayama T, Okura Y, Okada Y, Honma K, Nashimoto A, Sato N, Yokoyama A, Minamino T.
  • Journal Title: Int J Clin Oncol Volume: 20 Issue: 5 Pages: 872-7
  • DOI: 10.1007/s10147-015-0794-7
  • Peer Reviewed / Open Access
• [Journal Article] Frequency Characteristics and Associations with the Defibrillation Threshold of Ventricular Fibrillation in Patients with Implantable Cardioverter Defibrillators (2015)
  • Author(s): Iijima K, Chinushi M, Saitoh O, Hasegawa K, Sonoda K, Yagihara N, Sato A, Izumi D, Watanabe H, Furushima H, Aizawa Y, Minamino T.
  • Journal Title: Internal Medicine Volume: 54 Issue: 10 Pages: 1175-1182
  • DOI: 10.2169/internalmedicine.54.3113
  • NAID: 130005069800
  • ISSN: 0918-2918, 1349-7235
  • Peer Reviewed / Open Access
• [Journal Article] p53-Induced inflammation exacerbates cardiac dysfunction during pressure overload. (2015)
  • Author(s): Yoshida Y, Shimizu I, Katsuumi G, Jiao S, Suda M, Hayashi Y, Minamino T.
  • Journal Title: J Mol Cell Cardiol Volume: 85 Pages: 183-98
  • DOI: 10.1016/j.yjmcc.2015.06.001
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Elevated Endomyocardial Biopsy Macrophage-Related Markers in Intractable Myocardial Diseases. (2015)
  • Author(s): Hayashi Y, Hanawa H, Jiao S, Hasegawa G, Ohno Y, Yoshida K, Suzuki T, Kashimura T, Obata H, Tanaka K, Watanabe T, Minamino T.
  • Journal Title: Inflammation Volume: 38 Issue: 6 Pages: 2288-99
  • DOI: 10.1007/s10753-015-0214-1
  • Peer Reviewed / Open Access
• [Journal Article] Effect of a Low-Intensity Pulsed Ultrasound Device, SX-1001, on Clinical Symptoms in Buerger Disease With Limb Ischemia (2015)
  • Author(s): Higashi Y, Azuma N, Takeishi Y, Minamino T, Kihara Y, Node K, Sata M, Fukumoto Y, Origasa H, Matsuo H, Naritomi H, Fujita M, Shimizu W.
  • Journal Title: International Heart Journal Volume: 56 Issue: 6 Pages: 632-638
  • DOI: 10.1536/ihj.15-191
  • NAID: 130005113045
  • ISSN: 1349-2365, 1349-3299
  • Peer Reviewed / Open Access
• [Journal Article] Ventricular Rhythm and Hypotension in a Patient with Pheochromocytoma-induced Myocardial Damage and Reverse Takotsubo Cardiomyopathy (2015)
  • Author(s): Tagawa M, Nanba H, Suzuki H, Nakamura Y, Uchiyama H, Ochiai S, Terunuma M, Yahata K, Minamino T.
  • Journal Title: Internal Medicine Volume: 54 Issue: 18 Pages: 2343-2349
  • DOI: 10.2169/internalmedicine.54.4732
  • NAID: 130005099672
  • ISSN: 0918-2918, 1349-7235
  • Peer Reviewed / Open Access
• [Presentation] Future Perspectives of Basic Research for Cardiovascular and Metabolic Disease (2017)
  • Author(s): Minamino T.
  • Organizer: 第81回日本循環器学会学術集会
  • Place of Presentation: ホテル金沢(石川県金沢市)
  • Invited
• [Presentation] 老化から糖尿病治療方策を考える (2017)
  • Author(s): Minamino T.
  • Organizer: 第81回日本循環器学会学術集会
  • Place of Presentation: ホテル金沢(石川県金沢市)
  • Invited
• [Presentation] Role of cellular senescence in cardio-metabolic disease. (2017)
  • Author(s): Minamino T.
  • Organizer: Inha University Seminar
  • Place of Presentation: National Research Center for Sexual Medicine Dept. of Urology, Inha University School of Medicine(韓国)
  • Int'l Joint Research / Invited
• [Presentation] A Critical Role of Cellular Senescence in Metabolic and Cardiovascular Disease. (2017)
  • Author(s): Minamino T.
  • Organizer: Pulse of Asia Annual Meeting
  • Place of Presentation: Taipei International Convention Center(台北)
  • Int'l Joint Research / Invited
• [Presentation] Hypertension, diabetes, and vascular aging (2017)
  • Author(s): Minamino T.
  • Organizer: The 47th Annual Convention & Scientific Session of the Taiwan Society of Cardiology, 2017
  • Place of Presentation: Taipei International Convention Center(台北)
  • Int'l Joint Research / Invited
• [Presentation] Cellular Senescence and Age-Associated Disease. (2017)
  • Author(s): Minamino T.
  • Organizer: Keystone Sympojia
  • Place of Presentation: パシフィコ横浜 (神奈川県横浜市)
  • Int'l Joint Research / Invited
• [Presentation] 老化シグナルと心血管代謝ネットワーク (2017)
  • Author(s): Minamino T.
  • Organizer: 第17回日本抗加齢医学会総会
  • Place of Presentation: 東京国際フォーラム(東京都千代田区)
  • Invited
• [Presentation] Cellular senescence in cardiovascular disease - The future. (2017)
  • Author(s): Minamino T.
  • Organizer: Symposium, European Society of Cardiology
  • Place of Presentation: Barcelona, (Spain)
  • Int'l Joint Research / Invited
• [Presentation] Pathophysiological mechanisms of heart failure in diabetes. Joint with the Japanese Circulation Society. (2017)
  • Author(s): Minamino T.
  • Organizer: Symposium, European Society of Cardiology
  • Place of Presentation: Barcelona, (Spain)
  • Int'l Joint Research / Invited
• [Presentation] A role of senescence-induced inflammation in metabolic and cardiovascular disease. (2016)
  • Author(s): Minamino T.
  • Organizer: Joint Japan-Korea Young Investigator Conference on Autophagy
  • Place of Presentation: 新潟大学（新潟県新潟市）
  • Year and Date: 2016-02-18
  • Invited
• [Presentation] Roles of cellular aging signaling in lifestyle-related disease. Is anti-senescence therapy feasible? (2016)
  • Author(s): Minamino T.
  • Organizer: Robert and Arlene Kogod Center-Successful Aging Monday Seminar
  • Place of Presentation: Rochester, MN（アメリカ）
  • Year and Date: 2016-02-08
  • Int'l Joint Research / Invited
• [Presentation] 糖尿病血管障害の病態・生理 (2016)
  • Author(s): Minamino T.
  • Organizer: 第59回日本糖尿病学会年次学術集会
  • Place of Presentation: 国立京都国際会館(京都府京都市)
  • Invited
• [Presentation] A critical role of cellular senescence in metabolic and cardiovascular disease. (2016)
  • Author(s): Minamino T.
  • Organizer: The 26th International Conference the Korean Society for Gerontology
  • Place of Presentation: Hotel Laonzena, Daegu, (Korea)
  • Int'l Joint Research / Invited
• [Presentation] A critical role of cellular senescence in metabolic and cardiovascular disease. (2016)
  • Author(s): Minamino T.
  • Organizer: The 1st International Symposium on Stem Cell Aging and Disease
  • Place of Presentation: University of Tokyo, (東京都文京区)
  • Int'l Joint Research / Invited
• [Presentation] 老化シグナルによって制御される心血管代謝ネットワーク (2016)
  • Author(s): Minamino T.
  • Organizer: 循環制御医学会シンポジウム
  • Place of Presentation: ステーションカンファレンス東京(東京都千代田区)
  • Invited
• [Presentation] A critical role of cellular senescence in metabolic and cardiovascular disease. (2016)
  • Author(s): Minamino T.
  • Organizer: International Symposium of the Center for Animal Disease Models 2016-Metabolic disease and Aging-
  • Place of Presentation: 東京ガーデンパレス(東京都文京区)
  • Int'l Joint Research / Invited
• [Presentation] 老化からみた新しい脂質異常症の治療戦略～抗PCSK9交代レパーサへの期待～ (2016)
  • Author(s): Minamino T.
  • Organizer: 第22回日本心臓リハビリテーション学会学術集会
  • Place of Presentation: 東京国際フォーラム(東京都千代田区)
  • Invited
• [Presentation] 老化シグナルによって制御される心血管代謝ネットワーク (2016)
  • Author(s): Minamino T.
  • Organizer: 第7回 日本脳血管・認知症学会学術大会
  • Place of Presentation: 金沢都ホテル（石川県金沢市）
  • Invited
• [Presentation] Future direction for research in metabolism, adipose tissue and cardiovascular disease. Metabolism, adipose tissue and cardiovascular disease. (2016)
  • Author(s): Minamino T.
  • Organizer: European Society of Cardiology
  • Place of Presentation: Rome, (Italy)
  • Int'l Joint Research / Invited
• [Presentation] Cellular senescence and cardio metabolic disease. Joint with the Japanese Circulation Society. (2016)
  • Author(s): Minamino T.
  • Organizer: European Society of Cardiology
  • Place of Presentation: Rome, (Italy)
  • Int'l Joint Research / Invited
• [Presentation] 血管の老化を防ぐには？ (2016)
  • Author(s): Minamino T.
  • Organizer: 日本抗加齢協会アンチエイジングセミナー
  • Place of Presentation: フジテレビ本社屋（東京都江東区）
  • Invited
• [Presentation] 老化からみた生活習慣病の治療方策 (2016)
  • Author(s): Minamino T.
  • Organizer: 第30回日本エイズ学会学術集会・総会
  • Place of Presentation: かごしま県民交流センター（鹿児島県鹿児島市）
  • Invited
• [Presentation] Role of senescence-induced inflammation in lifestyle-related disease. (2016)
  • Author(s): Minamino T.
  • Organizer: The 14th Korea Japan Joint Symposium on Vascular Biology
  • Place of Presentation: 長崎ブリック(長崎県長崎市)
  • Int'l Joint Research / Invited
• [Presentation] 糖尿病の治療方策を老化の観点から考える (2016)
  • Author(s): Minamino T.
  • Organizer: CVEM
  • Place of Presentation: 東京コンベンションホール(東京都中央区)
  • Invited
• [Presentation] 老化シグナルによって制御される加齢関連疾患の発症メカニズムの解明 (2015)
  • Author(s): Minamino T.
  • Organizer: 第23回日本血管生物医学会学術集会
  • Place of Presentation: 神戸国際会議場（兵庫県神戸市）
  • Year and Date: 2015-12-10
  • Invited
• [Presentation] Role of cellular aging in cardiovascular and metabolic disease. (2015)
  • Author(s): Minamino T.
  • Organizer: The 59th Annual Scientific Meeting of The Korean Society of Cardiology
  • Place of Presentation: KIntex（Korea)
  • Year and Date: 2015-10-15
  • Int'l Joint Research / Invited
• [Presentation] Therapeutic angiogenesis in Japan. (2015)
  • Author(s): Minamino T.
  • Organizer: The 59th Annual Scientific Meeting of The Korean Society of Cardiology
  • Place of Presentation: KIntex (Korea)
  • Year and Date: 2015-10-15
  • Int'l Joint Research / Invited
• [Presentation] The functional implication of DNA damage in cardiometabolic disease. (2015)
  • Author(s): Minamino T.
  • Organizer: The 59th Annual Scientific Meeting of The Korean Society of Cardiology
  • Place of Presentation: KIntex (Korea)
  • Year and Date: 2015-10-15
  • Int'l Joint Research / Invited
• [Presentation] 心血管代謝老化制御による生活習慣病の治療方策 (2015)
  • Author(s): Minamino T.
  • Organizer: 第38回日本高血圧学会総会
  • Place of Presentation: ひめぎんホール（愛媛県松山市）
  • Year and Date: 2015-10-12
  • Invited
• [Presentation] Role of senescence-associated inflammation in lifestyle-related disease. (2015)
  • Author(s): Minamino T.
  • Organizer: 2015 International Cell Senescence Association
  • Place of Presentation: Santiago de Compostela (Spain)
  • Year and Date: 2015-07-19
  • Int'l Joint Research / Invited
• [Presentation] Role of senescence-associated inflammation in lifestyle-related disease (2015)
  • Author(s): Minamino T.
  • Organizer: 第15回日本抗加齢医学会総会
  • Place of Presentation: 福岡国際会議場（福岡県福岡市）
  • Year and Date: 2015-05-30
  • Invited
• [Presentation] 血圧変動からみた高血圧治療 (2015)
  • Author(s): Minamino T.
  • Organizer: 第56回日本神経学会学術集会ランチョンセミナー
  • Place of Presentation: ホテル日航新潟（新潟県新潟市）
  • Year and Date: 2015-05-23
  • Invited
• [Presentation] Molecular mechanisms of cardiovascular aging. (2015)
  • Author(s): Minamino T.
  • Organizer: 第79回日本循環器学会 Asian Session
  • Place of Presentation: リーガロイヤル大阪（大阪府大阪市）
  • Year and Date: 2015-04-24
  • Invited
• [Book] AGING SCIENCE MEDICINE (2016)
  • Author(s): 南野 徹
  • Publisher: メディカルレビュー
• [Book] 特集Men’sHealth (2016)
  • Author(s): 須田将吉、清水逸平、南野徹
  • Publisher: 日本医師会雑誌
• [Book] 女性医療のすべて (2016)
  • Author(s): 若杉崇幸、清水逸平、南野 徹
  • Publisher: メディカルレビュー
• [Book] medicina (2016)
  • Author(s): 萱森裕美、清水逸平、南野 徹
  • Total Pages: 1812
  • Publisher: 医学書院
• [Book] 特集 老化制御と疾患―エイジング研究の進歩― (2016)
  • Author(s): 勝海悟郎、清水逸平、吉田陽子、南野 徹
  • Publisher: 日本臨床
• [Book] 最新医学 (2016)
  • Author(s): 南場一美、清水逸平、吉田陽子、南野 徹
  • Publisher: 最新医学社
• [Book] 特集 老化制御と疾患―エイジング研究の進歩― (2016)
  • Author(s): 清水逸平、南野 徹
  • Publisher: 日本臨床
• [Book] 実験医学 (2016)
  • Author(s): 池上龍太郎、清水逸平、吉田陽子、南野徹
  • Publisher: 羊土社
• [Book] レスベラトロールの基礎 (2016)
  • Author(s): 池上龍太郎、清水逸平、吉田陽子、南野 徹
  • Publisher: メディカルレビュー
• [Book] nature REVIEWS CARDIOLOGY (2016)
  • Author(s): 南野 徹
  • Publisher: シュプリンガーヘルスケア
• [Book] 重症心不全診療マニュアル (2016)
  • Author(s): 藤木伸也、小幡裕明、南野徹
  • Publisher: 中外医学社
• [Book] 加齢のメカニズム (2016)
  • Author(s): 清水逸平、南野徹
  • Publisher: 日本臨床
• [Book] 心不全や肥満、糖尿病における白色・褐色脂肪不全の意義 (2016)
  • Author(s): 清水逸平、吉田陽子、南野徹
  • Publisher: Biomedical Gerontology
• [Book] 早期診断・治療のための～肺高血圧症Q&A (2015)
  • Author(s): 萱森裕美、小幡裕明、伊藤正洋、南野 徹
  • Publisher: 先端医学社
• [Book] 糖尿病・代謝・内分泌 (2015)
  • Author(s): 清水逸平、吉田陽子、南野徹
  • Publisher: Annual review
• [Book] 第3版アンチエイジング医学の基礎と臨床 (2015)
  • Author(s): 吉田陽子、南野 徹
  • Publisher: メジカルビュー社
• [Book] 脂質代謝異常と関連疾患 (2015)
  • Author(s): 須田将吉, 吉田陽子, 清水逸平, 南野徹
  • Publisher: LIC
• [Book] 新・血栓止血血管学 (2015)
  • Author(s): 須田将吉, 南野徹
  • Publisher: 金芳堂
• [Book] 第3版アンチエイジング医学の基礎と臨床 (2015)
  • Author(s): 須田将吉、南野 徹
  • Publisher: メジカルビュー社
• [Book] 機能性表示食品DATA BOOK (2015)
  • Author(s): 南野徹
  • Publisher: メディカルレビュー社
• [Book] 不整脈治療update (2015)
  • Author(s): 渡部裕、南野徹
  • Publisher: 医薬ジャーナル社
• [Book] 不整脈症候群～遺伝子変異から不整脈治療を捉える (2015)
  • Author(s): 渡部 裕、南野徹
  • Publisher: 南光堂
• [Book] 遺伝子変異から不整脈治療を捉える (2015)
  • Author(s): 佐藤光希、南野徹
  • Publisher: 南光堂
• [Book] 再生医療用語ハンドブック (2015)
  • Author(s): 南野徹、須田将吉
  • Total Pages: 85
  • Publisher: メディカルトリビューン
• [Book] 新薬展望2015治療における最近の新薬の位置づけ（薬効別）新薬の広場 (2015)
  • Author(s): 和泉 大輔，南野 徹
  • Publisher: 医薬ジャーナル
• [Book] 褐色脂肪とアンチエイジング (2015)
  • Author(s): 清水逸平、南野徹
  • Publisher: Anti Aging Medicine
• [Book] 血管医学 (2015)
  • Author(s): 清水逸平、南野徹
  • Publisher: 老化疾患における血管代謝ニッシェの変容と臓器記憶の形成
• [Book] 細胞老化・炎症と心臓のアンチエイジング (2015)
  • Author(s): 若杉嵩幸、吉田陽子、清水逸平、南野徹
  • Publisher: Anti Aging Medicine
• [Book] 細胞 (2015)
  • Author(s): 勝海悟郎、清水逸平、吉田陽子、南野徹
  • Publisher: ニューサイエンス社
• [Book] 細胞工学 (2015)
  • Author(s): 勝海悟郎、清水逸平、南野徹
  • Publisher: 秀潤社
• [Book] Angiology Frontier (2015)
  • Author(s): 勝海悟郎、清水逸平、南野徹
  • Publisher: メジカルレビュー社
• [Book] 別冊 診断と治療のABC 106 (2015)
  • Author(s): 池上龍太郎、清水逸平、吉田陽子、南野徹
  • Publisher: 最新医学社
• [Book] AGING SCIENCE (2015)
  • Author(s): 池上龍太郎、南野徹
  • Publisher: Anti Aging Medicine
• [Book] 末梢循環障害 (2015)
  • Author(s): 池上龍太郎、小澤拓也、南野徹
  • Publisher: Angiology Frontier
• [Book] 治療高血圧治療update-最新の治療動向- 合併症・ライフステージ別高血圧治療 (2015)
  • Author(s): 田中孔明、南野徹
  • Publisher: 日本臨床
• [Book] 別冊Bio Clinica:慢性炎症と疾患 (2015)
  • Author(s): 南野徹
  • Publisher: 北隆館
• [Book] 老化による炎症と心血管疾患 (2015)
  • Author(s): 萱森裕美、清水逸平、吉田陽子、南野徹
  • Publisher: 科学評論社
• [Book] 脂肪老化とバイオマーカー (2015)
  • Author(s): 林 由香、吉田陽子、清水逸平、南野徹
  • Publisher: Anti-aging Science
• [Book] メディカル・サイエンス・ダイジェスト (2015)
  • Author(s): 南野徹
  • Publisher: ニューサイエンス社
• [Book] Angiology Frontier (2015)
  • Author(s): 萱森裕美、南野徹
  • Publisher: メディカルレビュー社
• [Book] 月刊誌血圧 (2015)
  • Author(s): 小澤拓也、南野 徹
  • Publisher: 先端医学社
• [Remarks] 新潟大学大学院医歯学研究院循環器内科
  • URL: http://www.med.niigata-u.ac.jp/car/
• [Patent(Industrial Property Rights)] 心不全患者に対する内科的治療が有効であるか否かを予測するためのデータを収集する方法 (2016)
  • Inventor(s): 南野徹、清水逸平
  • Industrial Property Rights Holder: 南野徹、清水逸平
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2016-160569
  • Filing Date: 2016-08-18
• [Patent(Industrial Property Rights)] 老化細胞除去薬及び医薬組成物 (2016)
  • Inventor(s): 南野 徹
  • Industrial Property Rights Holder: 南野 徹
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2016-167679
  • Filing Date: 2016-08-30
• [Patent(Industrial Property Rights)] 老化マーカー及びその使用 (2015)
  • Inventor(s): 南野徹
  • Industrial Property Rights Holder: 南野徹
  • Industrial Property Rights Type: 特許
  • Filing Date: 2015-12-21