| Project/Area Number |
15K15308
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cardiovascular medicine
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| Research Institution | Nagoya University |
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Principal Investigator |
OUCHI NORIYUKI 名古屋大学, 医学(系)研究科(研究院), 寄附講座教授 (00595514)
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| Co-Investigator(Kenkyū-buntansha) |
OHASHI Koji 名古屋大学, 医学系研究科, 寄附講座助教 (10595515)
SHIBATA Rei 名古屋大学, 医学系研究科, 寄附講座准教授 (70343689)
MUROHARA Toyoaki 名古屋大学, 医学系研究科, 教授 (90299503)
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| Project Period (FY) |
2015-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
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| Keywords | 分子心臓病態学 / 虚血性心疾患 / 心臓分子病態学 |
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| Outline of Final Research Achievements |
We found that the adipokine C1q/TNF-related protein (CTRP) 1 is protective against acute cardiac injury following ischemia-reperfusion (I/R). CTRP1 knockout mice showed increased infarct size after I/R compared with control mice, which were accompanied by enhanced apoptosis and inflammatory response in ischemic heart. Administration of CTRP1 to wild-type mice led to reduction of myocardial infarct size following I/R. Furthermore, CTRP1 attenuated apoptosis and inflammatory reaction in cardiac myocytes by its ability to promote cyclic AMP-dependent pathway.
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