Role of C1q/TNF-related protein 1 in ischemic heart disease
Project/Area Number |
15K15308
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Cardiovascular medicine
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Research Institution | Nagoya University |
Principal Investigator |
OUCHI NORIYUKI 名古屋大学, 医学(系)研究科(研究院), 寄附講座教授 (00595514)
|
Co-Investigator(Kenkyū-buntansha) |
OHASHI Koji 名古屋大学, 医学系研究科, 寄附講座助教 (10595515)
SHIBATA Rei 名古屋大学, 医学系研究科, 寄附講座准教授 (70343689)
MUROHARA Toyoaki 名古屋大学, 医学系研究科, 教授 (90299503)
|
Project Period (FY) |
2015-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
|
Keywords | 分子心臓病態学 / 虚血性心疾患 / 心臓分子病態学 |
Outline of Final Research Achievements |
We found that the adipokine C1q/TNF-related protein (CTRP) 1 is protective against acute cardiac injury following ischemia-reperfusion (I/R). CTRP1 knockout mice showed increased infarct size after I/R compared with control mice, which were accompanied by enhanced apoptosis and inflammatory response in ischemic heart. Administration of CTRP1 to wild-type mice led to reduction of myocardial infarct size following I/R. Furthermore, CTRP1 attenuated apoptosis and inflammatory reaction in cardiac myocytes by its ability to promote cyclic AMP-dependent pathway.
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Report
(2 results)
Research Products
(6 results)
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[Journal Article] C1q/TNF-related protein-1 functions to protect against acute ischemic injury in the heart2016
Author(s)
Yuasa D.,Ohashi K.,Shibata R.,Mizutani N.,Kataoka Y.,Kambara T.,Uemura Y.,Matsuo K.,Kanemura N.,Hayakawa S.,Hiramatsu-Ito M.,Ito M.,Ogawa H.,Murate T.,Murohara T. and Ouchi N.
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Journal Title
FASEB J
Volume: 30
Issue: 3
Pages: 1065-1075
DOI
Related Report
Peer Reviewed
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[Journal Article] Omentin attenuates atherosclerotic lesion formation in apolipoprotein E-deficient mice.2016
Author(s)
Hiramatsu-Ito M, Shibata R, Ohashi K, Uemura Y, Kanemura N, Kambara T, Enomoto T, Yuasa D, Matsuo K, Ito M, Hayakawa S, Ogawa H, Otaka N, Kihara S, Murohara T and Ouchi N.
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Journal Title
Cardiovasc Res.
Volume: 110
Issue: 1
Pages: 107-117
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] FGF21 attenuates pathological myocardial remodeling following myocardial infarction through the adiponectin-dependent mechanism.2015
Author(s)
Joki Y, Ohashi K, Yuasa D, Shibata R, Ito M, Matsuo K, Kambara T, Uemura Y, Hayakawa S, Hiramatsu-Ito M, Kanemura N, Ogawa H, Daida H, Murohara T, Ouchi N.
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Journal Title
Biochem Biophys Res Commun.
Volume: 459
Issue: 1
Pages: 124-30
DOI
Related Report
Peer Reviewed
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[Journal Article] C1q/TNF-related protein 9 protects against acute myocardial injury through an AdipoR1-AMPK dependent mechanism.2015
Author(s)
Kambara T, Shibata R, Ohashi K, Matsuo K, Hiramatsu-Ito M, Enomoto T, Yuasa D, Ito M, Hayakawa S, Ogawa H, Aprahamian T, Walsh K, Murohara T, Ouchi N.
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Journal Title
Mol Cell Biol.
Volume: 35
Issue: 12
Pages: 2173-85
DOI
Related Report
Peer Reviewed
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