Production of human induced bronchiolar progenitors

• Project/Area Number: 15K15316
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Respiratory organ internal medicine
• Research Institution: Niigata University
• Principal Investigator: KIKUCHI Toshiaki 新潟大学, 医歯学系, 教授 (10280926)
• Co-Investigator(Renkei-kenkyūsha): KANEHIRA Masahiko 東北大学, 大学病院, 助教 (90374941)
• Research Collaborator: SUZUKI Takuji 自治医科大学, 医学部, 准教授 (80344670) ; GOMI Kazunori コーネル大学 (20400335)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 前駆細胞

Outline of Final Research Achievements

The aim of this study is to establish the method of preparing mouse induced bronchiolar progenitor cells (referred to in the text as “iBP cells”), which will be applied to that of preparing human iBP cells. The achievement of this study is expected not only to provide mechanistic insights into the cell dedifferentiation specific to respiratory tract epithelial cells, but also to contribute to development of innovative medical technology by offering biomaterial indispensable for regenerative medicine. This grant support for 3 years enabled us to elucidate the characteristic feature of iBP cells and the molecular mechanism controlling the dedifferentiation step toward iBP cells.

Research Products

• [Journal Article] Peripheral alveolar nitric oxide concentration reflects alveolar inflammation in autoimmune pulmonary alveolar proteinosis. (2018)
  • Author(s): Hirano T, Ohkouchi S, Tode N, Kobayashi M, Ono M, Satoh T, Mitsuishi Y, Watanabe A, Tabata M, Irokawa T, Ogawa H, Sugiura H, Kikuchi T, Akasaka K, Tazawa R, Inoue Y, Nakata K, Kurosawa H, Ichinose M.
  • Journal Title: ERJ Open Research. Volume: 4 Pages: 00071-2017
  • DOI: 10.1183/23120541.00071-2017
  • Peer Reviewed / Open Access
• [Journal Article] In vitro activity of various antibiotics against clinical strains of Legionella species isolated in Japan. (2018)
  • Author(s): Miyashita N, Kobayashi I, Higa F, Aoki Y, Kikuchi T, Seki M, Tateda K, Maki N, Uchino K, Ogasawara K, Kurachi S, Ishikawa T, Ishimura Y, Kanesaka I, Kiyota H, Watanabe A.
  • Journal Title: J Infect Chemother. Volume: 24 Pages: 325-329
  • DOI: 10.1016/j.jiac.2018.01.018
  • Peer Reviewed / Open Access
• [Journal Article] Clinical significance of interferon-γ neutralizing autoantibodies against disseminated nontuberculous mycobacterial disease. (2018)
  • Author(s): Aoki A, Sakagami T, Yoshizawa K, Shima K, Toyama M, Tanabe Y, Moro H, Aoki N, Watanabe S, Koya T, Hasegawa T, Morimoto K, Kurashima A, Hoshino Y, Trapnell BC, Kikuchi T.
  • Journal Title: Clin Infect Dis. Volume: 66 Pages: 1239-1245
  • DOI: 10.1093/cid/cix996
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Endobronchial topical amphotericin B instillation for pulmonary chromomycosis after lung transplantation: A case report. (2018)
  • Author(s): Mitomo H, Sakurada A, Matsuda Y, Notsuda H, Watanabe T, Oishi H, Niikawa H, Maeda S, Noda M, Sado T, Amemiya T, Yoshida Y, Kikuchi T, Kamei K, Okada Y.
  • Journal Title: Transplant Proc. Volume: 50 Pages: 939-942
  • DOI: 10.1016/j.transproceed.2017.12.028
  • Peer Reviewed / Open Access
• [Journal Article] A Cluster Analysis of Bronchial Asthma Patients with Depressive Symptoms (2018)
  • Author(s): Seino Y, Hasegawa T, Koya T, Sakagami T, Mashima I, Shimizu N, Muramatsu Y, Muramatsu K, Suzuki E, Kikuchi T.
  • Journal Title: Intern. Med. Volume: 印刷中 Issue: 14 Pages: 1967-1975
  • DOI: 10.2169/internalmedicine.9073-17
  • NAID: 130006464153
  • Peer Reviewed / Open Access
• [Journal Article] Clinical and genetic implications of mutation burden in squamous cell carcinoma of the lung. (2018)
  • Author(s): Okamoto Tatsuro、Takada Kazuki、Sato Seijiro、Toyokawa Gouji、Tagawa Tetsuzo、Shoji Fumihiro、Nakanishi Ryota、Oki Eiji、Koike Terumoto、Nagahashi Masayuki、Ichikawa Hiroshi、Shimada Yoshifumi、Watanabe Satoshi、Kikuchi Toshiaki、Akazawa Kouhei、Lyle Stephen、Takabe Kazuaki、Okuda Shujiro、Sugio Kenji
  • Journal Title: Ann Surg Oncol. Volume: 25 Pages: 1564-1571
  • DOI: 10.1245/s10434-018-6401-1
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Natural course and potential prognostic factors for sleep-disordered breathing in multiple system atrophy. (2017)
  • Author(s): Ohshima Y, Nakayama H, Matsuyama N, Hokari S, Sakagami T, Sato T, Koya T, Takahashi T, Kikuchi T, Nishizawa M, Shimohata T
  • Journal Title: Sleep Med. Volume: 34 Pages: 13-17
  • DOI: 10.1016/j.sleep.2017.01.020
  • Peer Reviewed / Open Access
• [Journal Article] Megalin blockade with cilastatin suppresses drug-induced nephrotoxicity. (2017)
  • Author(s): Hori Y, Aoki N, Kuwahara S, Hosojima M, Kaseda R, Goto S, Iida T, De S, Kabasawa H, Kaneko R, Aoki H, Tanabe Y, Kagamu H, Narita I, Kikuchi T, Saito A
  • Journal Title: J Am Soc Nephrol. Volume: 未定 Pages: 1783-1791
  • DOI: 10.1681/asn.2016060606
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Exome sequencing deciphers a germline MET mutation in familial epidermal growth factor receptor-mutant lung cancer (2017)
  • Author(s): Tode N, Kikuchi T, Sakakibara T, Hirano T, Inoue A, Ohkouchi S, Tamada T, Okazaki T, Koarai A, Sugiura H, Niihori T, Aoki Y, Nakayama K, Matsumoto K, Matsubara Y, Yamamoto M, Watanabe A, Nukiwa T, Ichinose M.
  • Journal Title: Cancer Science Volume: 印刷中 Pages: 1263-1270
  • DOI: 10.1111/cas.13233
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] A-DROP system for prognostication of NHCAP inpatients. (2017)
  • Author(s): Koizumi T, Tsukada H, Ito K, Shibata S, Hokari S, Tetsuka T, Aoki N, Moro H, Tanabe Y, Kikuchi T
  • Journal Title: J Infect Chemother. Volume: 23 Pages: 523-530
  • DOI: 10.1016/j.jiac.2017.04.013
  • Peer Reviewed / Open Access
• [Journal Article] Transfer of in vitro-expanded naïve T cells after lymphodepletion enhances antitumor immunity through the induction of polyclonal antitumor effector T cells. (2017)
  • Author(s): Tanaka Tomohiro、Watanabe Satoshi、Takahashi Miho、Sato Ko、Saida Yu、Baba Junko、Arita Masashi、Sato Miyuki、Ohtsubo Aya、Shoji Satoshi、Nozaki Koichiro、Ichikawa Kosuke、Kondo Rie、Aoki Nobumasa、Ohshima Yasuyoshi、Sakagami Takuro、Abe Tetsuya、Moro Hiroshi、Koya Toshiyuki、Tanaka Junta
  • Journal Title: PLoS One. Volume: 12
  • DOI: 10.1371/journal.pone.0183976
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Phenotypic analysis of asthma in Japanese athletes (2017)
  • Author(s): Tsukioka K, Koya T, Ueno H, Hayashi M, Sakagami T, Hasegawa T, Arakawa M, Suzuki E, Kikuchi T.
  • Journal Title: Allergol. Int. Volume: 66 Issue: 4 Pages: 550-556
  • DOI: 10.1016/j.alit.2017.02.009
  • NAID: 130006179506
  • Peer Reviewed / Open Access
• [Journal Article] Clinical presentation of Legionella pneumonia: Evaluation of clinical scoring systems and therapeutic efficacy. (2017)
  • Author(s): Miyashita N, Higa F, Aoki Y, Kikuchi T, Seki M, Tateda K, Maki N, Uchino K, Ogasawara K, Kiyota H, Watanabe A.
  • Journal Title: J Infect Chemother. Volume: 23 Pages: 727-732
  • DOI: 10.1016/j.jiac.2017.09.001
  • Peer Reviewed / Open Access
• [Journal Article] Effect of lymphodepletion on donor T cells and the role of recipient cells persisting after cytotoxic treatments in cancer Immunotherapies. (2017)
  • Author(s): Watanabe Satoshi、Arita Masashi、Takahashi Miho、Saida Yu、Koya Toshiyuki、Kikuchi Toshiaki
  • Journal Title: Crit Rev Immunol. Volume: 37 Pages: 59-73
  • DOI: 10.1615/critrevimmunol.2018019497
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Cytokine profiles of amyopathic dermatomyositis with interstitial lung diseases treated with mycophenolate. (2017)
  • Author(s): Masachika Hayashi, Ami Aoki, Katsuaki Asakawa, Takuro Sakagami, Toshiaki Kikuchi, and Toshinori Takada
  • Journal Title: Respirol Case Rep Volume: 5 Pages: 1-4
  • DOI: 10.1002/rcr2.235
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Effects of sublingual immunotherapy in a murine asthma model sensitized by intranasal administration of house dust mite extracts (2017)
  • Author(s): Shima K, Koya T, Tsukioka K, Sakagami T, Hasegawa T, Fukano C, Ohashi-Doi K, Watanabe S, Suzuki E, Kikuchi T.
  • Journal Title: Allergol. Int. Volume: 66 Issue: 1 Pages: 89-96
  • DOI: 10.1016/j.alit.2016.05.012
  • NAID: 130005308448
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Mycophenolate mofetil for the patients with interstitial lung diseases in amyopathic dermatomyositis with anti-MDA-5 antibodies. (2017)
  • Author(s): Masachika Hayashia, Toshiaki Kikuchia, and Toshinori Takada
  • Journal Title: Clin Rheumatol Volume: 36 Pages: 239-240
  • DOI: 10.1007/s10067-016-3443-2
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Two cases of pseudo-achalasia with lung cancer: a case report and short literature review. (2016)
  • Author(s): Hirano T, Miyauchi E, Inoue A, Igusa R, Chiba S, Sakamoto K, Sugiura H, Kikuchi T, Ichinose M.
  • Journal Title: Respir Investig Volume: 54 Pages: 494-499
  • DOI: 10.1016/j.resinv.2016.04.006
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Extracellular ATP is involved in dsRNA-induced MUC5AC production via P2Y2R in human airway epithelium. (2016)
  • Author(s): Shishikura Y, Koarai A, Aizawa H, Yamaya M, Sugiura H, Watanabe M, Hashimoto Y, Numakura T, Makiguti T, Abe K, Yamada M, Kikuchi T, Hoshikawa Y, Okada Y, Ichinose M.
  • Journal Title: Respir Res Volume: 17 Pages: 121-121
  • DOI: 10.1186/s12931-016-0438-0
  • Peer Reviewed / Open Access
• [Journal Article] OX40 ligand newly expressed on bronchiolar progenitors mediates infection and further exacerbates pneumoria. (2016)
  • Author(s): Hirano T, Kikuchi T, Tode N, Santoso A, Yamada M, Mitsuhashi Y, Komatsu R, Kawabe T, Tanimoto T, Ishii N, Tanaka Y, Nishimura H, Nukiwa T, Watanabe A, Ichinose M.
  • Journal Title: EMBO Mol Med Volume: 8 Pages: 422-436
  • DOI: 10.15252/emmm.201506154
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Syndecan 4 mediates Nrf2-dependent expansion of bronchiolar progenitors that protect against lung inflammation. (2016)
  • Author(s): Santoso A, Kikuchi T, Tode N, Hirano T, Komatsu R, Damayanti T, Motohashi H, Yamamoto M, Kojima T, Uede T, Nukiwa T, Ichinose M
  • Journal Title: Mol Ther Volume: 24 Pages: 41-52
  • DOI: 10.1038/mt.2015.153
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] 27-Hydroxycholesterol accelerates cellular senescence in human lung resident cells. (2016)
  • Author(s): Hashimoto Y, Sugiura H, Togo S, Koarai A, Abe K, Yamada M, Ichikawa T, Kikuchi T, Numakura T, Onodera K, Tanaka R, Sato K, Yanagisawa S, Okazaki T, Tamada T, Kikuchi T, Hoshikawa Y, Okada Y, Ichinose M.
  • Journal Title: Am J Physiol Lung Cell Mol Physiol. Volume: 310
  • DOI: 10.1152/ajplung.00351.2015
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Possible role of Kruppel-like factor 5 in the remodeling of small airways and pulmonary vessels in chronic obstructive pulmonary disease. (2016)
  • Author(s): Abe. K., H. Sugiura, Y. Hashimoto, T. Ichikawa, A. Koarai, M. Yamada, T. Numakura, K. Onodera, R. Tanaka, K. Sato, S. Yanagisawa, T. Okazaki, T. Tamada, T. Kikuchi and M. Ichinose.
  • Journal Title: Respir Res. Volume: 17 Pages: 7-7
  • DOI: 10.1186/s12931-016-0322-y
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Two cases of endobronchial aspergilloma complicated with primary and metastatic lung cancer: A case report and literature review. (2016)
  • Author(s): Hirano T, Yamada M, Igusa R, Tanno A, Numakura T, Sakamoto K, Kikuchi T, Ichinose M.
  • Journal Title: Respir Investig Volume: 54
  • DOI: 10.1016/j.resinv.2015.12.005
  • Peer Reviewed / Open Access
• [Journal Article] Simultaneous development of sarcoidosis and cutaneous vasculitis in a patient with refractory Crohn’s disease during infliximab therapy. (2016)
  • Author(s): Numakura T, Tamada T, Nara M, Muramatsu S, Murakami K, Kikuchi T, Kobayashi M, Muroi M, Okazaki T, Takagi S, Eishi Y, Ichinose M.
  • Journal Title: BMC Pulm Med Volume: 16 Pages: 30-30
  • DOI: 10.1186/s12890-016-0193-5
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Chronic inflammation, lymphangiogenesis, and effect of an anti-VEGFR therapy in a mouse model and in human patients with aspiration pneumonia (2015)
  • Author(s): Nihei M, Okazaki T, Ebihara S, Kobayashi M, Niu K, Gui P, Tamai T, Nukiwa T, Yamaya M, Kikuchi T, Nagatomi R, Ebihara T, Ichinose M.
  • Journal Title: J Pathology Volume: ;235 Pages: 632-45
  • DOI: 10.1002/path.4473
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] 肺MAC症の病態と菌側因子 (2017)
  • Author(s): 菊地利明
  • Organizer: 第92回日本結核病学会総会
  • Place of Presentation: 東京国際フォーラム、千代田区、東京都
  • Year and Date: 2017-03-23
  • Invited
• [Presentation] ゲノム医学からみた肺感染症 (2017)
  • Author(s): 菊地利明
  • Organizer: 第57回日本呼吸器学会学術講演会
  • Invited
• [Presentation] Autoimmune Nontuberculous Mycobacterial Disease:Characteristic Phenotypes of Cases with Anti-Interferon-g Neutralizing Autoantibodies. (2017)
  • Author(s): A. Aoki, T. Sakagami, K. Yoshizawa, K. Shima, N. Aoki, H. Moro, Y. Tanabe, T. Koya, T. Hasegawa, T. Kikuchi.
  • Organizer: 2017 American Thoracic Society International Conference
  • Int'l Joint Research
• [Presentation] The Risk of Exacerbation for Asthma from Questionnaire Survey in Japanese Population. (2017)
  • Author(s): H. Ueno, T. Koya, K. Yoshizawa, A. Aoki, Y. Kimura, H. Takeuchi, M. Hayashi, T. Sakagami, T. Kikuchi, T. Hasegawa, E. Suzuki.
  • Organizer: 2017 American Thoracic Society International Conference
  • Int'l Joint Research
• [Presentation] Comparison Between Ventilator-Associated Events and Conventional Ventilator Associated Pneumonia Surveillance in Japan. (2017)
  • Author(s): M. Sato, Y. Tanabe, M. Uchiyama, A. Sakagami, C. Tsubata, H. Cho, N. Aoki, H. Moro, H. Endoh, T. Kikuchi, A. Saitoh.
  • Organizer: 2017 American Thoracic Society International Conference
  • Int'l Joint Research
• [Presentation] Establishment of a Web-Based Inquiry System for Elemental Analysis of Lung Tissue of Occupational Lung Diseases. (2017)
  • Author(s): H. Moriyama, M. Kobayashi, A. Aoki, K. Asakawa, T. Sakagami, T. Koya, T. Ohdaira, T. Takada, T. Kikuchi.
  • Organizer: 2017 American Thoracic Society International Conference
  • Int'l Joint Research
• [Presentation] Anti-BPIFB1 Autoantibodies Were Identified in Three Cases with Idiopathic Interstitial Lung Disease. (2017)
  • Author(s): K. Yoshizawa, T. Sakagami, A. Aoki, K. Asakawa, T. Koya, T. Takada, T. Kikuchi.
  • Organizer: 2017 American Thoracic Society International Conference
  • Int'l Joint Research
• [Presentation] Involvement of Extracellular ATP in Mucus Production During Rhinovirus Infection. (2017)
  • Author(s): H. Aizawa, A. Koarai, Y. Shishikura, M. Yamaya, H. Sugiura, M. Watanabe, Y. Hashimoto, T. Numakura, T. Makiguchi, K. Abe, M. Yamada, T. Kikuchi, Y. Hoshikawa, Y. Okada, M. Ichinose.
  • Organizer: 2017 American Thoracic Society International Conference
  • Int'l Joint Research
• [Presentation] Mycophenolate Mofetil for Japanese Patients with Interstitial Lung Diseases in Amyopathic Dermatomyositis with Anti-MDA-5 Antibody. (2017)
  • Author(s): T. Takada, K. Asakawa, A. Aoki, M. Hayashi, T. Sakagami, T. Kikuchi.
  • Organizer: 2017 American Thoracic Society International Conference
  • Int'l Joint Research
• [Presentation] 気道上皮前駆細胞による抗炎症応答 (2017)
  • Author(s): 菊地利明
  • Organizer: 第48回ヒューマンサイエンス総合研究セミナー
  • Place of Presentation: 砂防会館別館、千代田区、東京都
  • Invited
• [Presentation] 呼吸器感染症を斬る─新世代に託される課題─ (2016)
  • Author(s): 菊地利明
  • Organizer: 第65回日本感染症学会東日本地方会学術集会 第63回日本化学療法学会東日本支部総会 合同学会
  • Place of Presentation: 朱鷺メッセ、新潟市、新潟県
  • Year and Date: 2016-10-26
  • Invited
• [Presentation] インフルエンザ感染 (2016)
  • Author(s): 菊地利明
  • Organizer: 第31回日本糖尿病合併症学会
  • Place of Presentation: 仙台国際センター、仙台市、宮城県
  • Year and Date: 2016-10-07
  • Invited
• [Presentation] The pulmonary OX40 ligand expression induced by the influenza infection plays a potential role in the pathogenesis. (2016)
  • Author(s): T. Hirano, T. Kikuchi, N. Tode, H. Sugiura, M. Ichinose,
  • Organizer: American Thoracic Society International Conference
  • Place of Presentation: Moscone Center, San Francisco, CA, USA
  • Year and Date: 2016-05-13
  • Int'l Joint Research
• [Presentation] 抗酸菌感染症の現状と将来展望 (2016)
  • Author(s): 菊地利明
  • Organizer: 第90回日本感染症学会総会・学術講演会
  • Place of Presentation: 仙台国際センター、仙台市、宮城県
  • Year and Date: 2016-04-15
  • Invited
• [Presentation] 非結核性抗酸菌症 (2016)
  • Author(s): 菊地利明
  • Organizer: 第56回日本呼吸器学会学術講演会
  • Place of Presentation: 国立京都国際会館、京都市、京都府
  • Year and Date: 2016-04-08
  • Invited
• [Presentation] Bronchial progenitor cells function as antigen presenting cells. (2015)
  • Author(s): T Hirano, T Kikuchi, T Tode, M Ichinose.
  • Organizer: American Thoracic Society International Conference
  • Place of Presentation: Denver（米国）
  • Year and Date: 2015-05-15
• [Presentation] Whole-exome sequencing of familial non-small cell lung cancer patients with the EGFR gene mutations. (2015)
  • Author(s): .N. Tode, T Kikuchi, T Hirano, A Santoso, M Ichinose.
  • Organizer: American Thoracic Society International Conference
  • Place of Presentation: Denver（米国）
  • Year and Date: 2015-05-15
• [Presentation] シンデカン4による細気管支前駆細胞への脱分化機構を介した肺炎症に対する新規治療法 (2015)
  • Author(s): 小松理世、菊地利明、アリフ サントソ、平野泰三、東出直樹、一ノ瀬正和
  • Organizer: 第55回日本呼吸器学会学術講演会
  • Place of Presentation: 東京国際フォーラム（東京都・千代田区）
  • Year and Date: 2015-04-17
• [Presentation] 気道上皮前駆細胞はインフルエンザウイルスの細胞感受性が最も高い (2015)
  • Author(s): 平野泰三、菊地利明、東出直樹、一ノ瀬正和
  • Organizer: 第55回日本呼吸器学会学術講演会
  • Place of Presentation: 東京国際フォーラム（東京都・千代田区）
  • Year and Date: 2015-04-17
• [Presentation] EGFR遺伝子変異を伴う家族性肺腺癌患者における遺伝学的機序の解明 (2015)
  • Author(s): 東出直樹, 菊地利明, 平野泰三, Arif Santoso, 一ノ瀬正和,
  • Organizer: 第55回日本呼吸器学会学術講演会
  • Place of Presentation: 東京国際フォーラム（東京都・千代田区）
  • Year and Date: 2015-04-17
• [Book] Lung Disease Associated with Rheumatioid Arthritis. (2018)
  • Author(s): Moro H, Kikuchi T.
  • Total Pages: 199
  • Publisher: Springer Nature Singapore Pte
• [Book] 診療ガイドライン UP-TO-DATE 2018-2019 (2017)
  • Author(s): 茂呂寛、菊地利明
  • Total Pages: 1037
  • Publisher: メディカルレビュー社
• [Book] 抗菌薬パーフェクトガイド (2016)
  • Author(s): 菊地利明
  • Total Pages: 359
  • Publisher: ヴァン メディカル
• [Book] 咳の診かた、止めかた (2016)
  • Author(s): 黒川允、菊地利明
  • Total Pages: 246
  • Publisher: 羊土社
• [Book] 診療ガイドライン UP-TO-DATE 2016-2017 (2016)
  • Author(s): 菊地利明
  • Total Pages: 942
  • Publisher: メディカルレビュー社
• [Book] 最新透析医療 先端技術との融合 (2016)
  • Author(s): 三浦理、各務博、風間順一郎、成田一衛、菊地利明
  • Total Pages: 859
  • Publisher: 医薬ジャーナル社
• [Remarks] 新潟大学大学院医歯学総合研究科 呼吸器・感染症内科学分野
  • URL: http://www.med.niigata-u.ac.jp/resp/welcome.html
• [Remarks] 新潟大学大学院医歯学総合研究科呼吸器・感染症内科学分野
  • URL: http://www.med.niigata-u.ac.jp/resp/welcome.html
• [Remarks] 新潟大学大学院医歯学総合研究科 呼吸器･感染症内科学分野
  • URL: http://www.med.niigata-u.ac.jp/resp/welcome.html
• [Patent(Industrial Property Rights)] 抗ヒトOX40リガンド抗体を用いたインフルエンザの新規治療法 (2015)
  • Inventor(s): 菊地利明、平野泰三、一ノ瀬正和、石井直人、田中勇悦
  • Industrial Property Rights Holder: 菊地利明、平野泰三、一ノ瀬正和、石井直人、田中勇悦
  • Industrial Property Rights Type: 特許
  • Filing Date: 2015-06-30
  • Application Year: 2015
  • Overseas