Production of human induced bronchiolar progenitors
Project/Area Number |
15K15316
|
Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
Allocation Type | Multi-year Fund |
Research Field |
Respiratory organ internal medicine
|
Research Institution | Niigata University |
Principal Investigator |
|
Co-Investigator(Renkei-kenkyūsha) |
KANEHIRA Masahiko 東北大学, 大学病院, 助教 (90374941)
|
Research Collaborator |
SUZUKI Takuji 自治医科大学, 医学部, 准教授 (80344670)
GOMI Kazunori コーネル大学 (20400335)
|
Project Period (FY) |
2015-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
|
Keywords | 前駆細胞 |
Outline of Final Research Achievements |
The aim of this study is to establish the method of preparing mouse induced bronchiolar progenitor cells (referred to in the text as “iBP cells”), which will be applied to that of preparing human iBP cells. The achievement of this study is expected not only to provide mechanistic insights into the cell dedifferentiation specific to respiratory tract epithelial cells, but also to contribute to development of innovative medical technology by offering biomaterial indispensable for regenerative medicine. This grant support for 3 years enabled us to elucidate the characteristic feature of iBP cells and the molecular mechanism controlling the dedifferentiation step toward iBP cells.
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Report
(4 results)
Research Products
(56 results)
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[Journal Article] A Cluster Analysis of Bronchial Asthma Patients with Depressive Symptoms2018
Author(s)
Seino Y, Hasegawa T, Koya T, Sakagami T, Mashima I, Shimizu N, Muramatsu Y, Muramatsu K, Suzuki E, Kikuchi T.
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Journal Title
Internal Medicine
Volume: 57
Issue: 14
Pages: 1967-1975
DOI
NAID
ISSN
0918-2918, 1349-7235
Year and Date
2018-07-15
Related Report
Peer Reviewed / Open Access
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[Journal Article] Peripheral alveolar nitric oxide concentration reflects alveolar inflammation in autoimmune pulmonary alveolar proteinosis.2018
Author(s)
Hirano T, Ohkouchi S, Tode N, Kobayashi M, Ono M, Satoh T, Mitsuishi Y, Watanabe A, Tabata M, Irokawa T, Ogawa H, Sugiura H, Kikuchi T, Akasaka K, Tazawa R, Inoue Y, Nakata K, Kurosawa H, Ichinose M.
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Journal Title
ERJ open research
Volume: 4
Issue: 1
Pages: 00071-2017
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] In vitro activity of various antibiotics against clinical strains of Legionella species isolated in Japan.2018
Author(s)
Miyashita N, Kobayashi I, Higa F, Aoki Y, Kikuchi T, Seki M, Tateda K, Maki N, Uchino K, Ogasawara K, Kurachi S, Ishikawa T, Ishimura Y, Kanesaka I, Kiyota H, Watanabe A.
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Journal Title
J Infect Chemother.
Volume: 24
Issue: 5
Pages: 325-329
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Clinical significance of interferon-γ neutralizing autoantibodies against disseminated nontuberculous mycobacterial disease.2018
Author(s)
Aoki A, Sakagami T, Yoshizawa K, Shima K, Toyama M, Tanabe Y, Moro H, Aoki N, Watanabe S, Koya T, Hasegawa T, Morimoto K, Kurashima A, Hoshino Y, Trapnell BC, Kikuchi T.
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Journal Title
Clin Infect Dis.
Volume: 66
Issue: 8
Pages: 1239-1245
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Endobronchial topical amphotericin B instillation for pulmonary chromomycosis after lung transplantation: A case report.2018
Author(s)
Mitomo H, Sakurada A, Matsuda Y, Notsuda H, Watanabe T, Oishi H, Niikawa H, Maeda S, Noda M, Sado T, Amemiya T, Yoshida Y, Kikuchi T, Kamei K, Okada Y.
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Journal Title
Transplant Proc.
Volume: 50
Issue: 3
Pages: 939-942
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Natural course and potential prognostic factors for sleep-disordered breathing in multiple system atrophy2017
Author(s)
Ohshima Y, Nakayama H, Matsuyama N, Hokari S, Sakagami T, Sato T, Koya T, Takahashi T, Kikuchi T, Nishizawa M, Shimohata T
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Journal Title
Sleep Medicine
Volume: 34
Pages: 13-17
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Megalin Blockade with Cilastatin Suppresses Drug-Induced Nephrotoxicity2017
Author(s)
Hori Y, Aoki N, Kuwahara S, Hosojima M, Kaseda R, Goto S, Iida T, De S, Kabasawa H, Kaneko R, Aoki H, Tanabe Y, Kagamu H, Narita I, Kikuchi T, Saito A.
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Journal Title
J Am Soc Nephrol
Volume: in press
Issue: 6
Pages: 1783-1791
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Exome sequencing deciphers a germline MET mutation in familial epidermal growth factor receptor-mutant lung cancer.2017
Author(s)
Tode N, Kikuchi T, Sakakibara T, Hirano T, Inoue A, Ohkouchi S, Tamada T, Okazaki T, Koarai A, Sugiura H, Niihori T, Aoki Y, Nakayama K, Matsumoto K, Matsubara Y, Yamamoto M, Watanabe A, Nukiwa T, Ichinose M.
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Journal Title
Cancer Sci
Volume: 印刷中
Issue: 6
Pages: 1263-1270
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Clinical presentation of Legionella pneumonia: Evaluation of clinical scoring systems and therapeutic efficacy.2017
Author(s)
Miyashita N, Higa F, Aoki Y, Kikuchi T, Seki M, Tateda K, Maki N, Uchino K, Ogasawara K, Kiyota H, Watanabe A.
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Journal Title
J Infect Chemother.
Volume: 23
Issue: 11
Pages: 727-732
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Effects of sublingual immunotherapy in a murine asthma model sensitized by intranasal administration of house dust mite extracts2017
Author(s)
Shima K, Koya T, Tsukioka K, Sakagami T, Hasegawa T, Fukano C, Ohashi-Doi K, Watanabe S, Suzuki E, Kikuchi T.
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Journal Title
Allergology International
Volume: 66
Issue: 1
Pages: 89-96
DOI
NAID
ISSN
1323-8930, 1440-1592
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Extracellular ATP is involved in dsRNA-induced MUC5AC production via P2Y2R in human airway epithelium.2016
Author(s)
Shishikura Y, Koarai A, Aizawa H, Yamaya M, Sugiura H, Watanabe M, Hashimoto Y, Numakura T, Makiguti T, Abe K, Yamada M, Kikuchi T, Hoshikawa Y, Okada Y, Ichinose M.
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Journal Title
Respir Res
Volume: 17
Issue: 1
Pages: 121-121
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] OX40 ligand newly expressed on bronchiolar progenitors mediates influenza infection and further exacerbates pneumonia.2016
Author(s)
Hirano T, Kikuchi T, Tode N, Santoso A, Yamada M, Mitsuhashi Y, Komatsu R, Kawabe T, Tanimoto T, Ishii N, Tanaka Y, Nishimura H, Nukiwa T, Watanabe A, Ichinose M.
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Journal Title
EMBO Mol Med.
Volume: 8
Issue: 4
Pages: 422-436
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Syndecan 4 Mediates Nrf2-dependent Expansion of Bronchiolar Progenitors That Protect Against Lung Inflammation.2016
Author(s)
Santoso A, Kikuchi T, Tode N, Hirano T, Komatsu R, Damayanti T, Motohashi H, Yamamoto M, Kojima T, Uede T, Nukiwa T, Ichinose M.
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Journal Title
Mol Ther.
Volume: 24
Issue: 1
Pages: 41-52
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] 27-hydroxycholesterol accelerates cellular senescence in human lung resident cells.2016
Author(s)
Hashimoto Y, Sugiura H, Togo S, Koarai A, Abe K, Yamada M, Ichikawa T, Kikuchi T, Numakura T, Onodera K, Tanaka R, Sato K, Yanagisawa S, Okazaki T, Tamada T, Kikuchi T, Hoshikawa Y, Okada Y, Ichinose M.
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Journal Title
Am J Physiol Lung Cell Mol Physiol
Volume: 310
Issue: 11
Pages: L1028-L1041
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Possible role of Krüppel-like factor 5 in the remodeling of small airways and pulmonary vessels in chronic obstructive pulmonary disease.2016
Author(s)
Abe. K., H. Sugiura, Y. Hashimoto, T. Ichikawa, A. Koarai, M. Yamada, T. Numakura, K. Onodera, R. Tanaka, K. Sato, S. Yanagisawa, T. Okazaki, T. Tamada, T. Kikuchi and M. Ichinose.
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Journal Title
Respir Res
Volume: 17
Issue: 1
Pages: 7-7
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Simultaneous development of sarcoidosis and cutaneous vasculitis in a patient with refractory Crohn's disease during infliximab therapy.2016
Author(s)
Numakura T, Tamada T, Nara M, Muramatsu S, Murakami K, Kikuchi T, Kobayashi M, Muroi M, Okazaki T, Takagi S, Eishi Y, Ichinose M.
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Journal Title
BMC Pulm Med.
Volume: 16
Issue: 1
Pages: 30-30
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Chronic inflammation, lymphangiogenesis, and effect of an anti-VEGFR therapy in a mouse model and in human patients with aspiration pneumonia.2015
Author(s)
Nihei M, Okazaki T, Ebihara S, Kobayashi M, Niu K, Gui P, Tamai T, Nukiwa T, Yamaya M, Kikuchi T, Nagatomi R, Ebihara T, Ichinose M.
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Journal Title
J Pathol
Volume: ;235
Issue: 4
Pages: 632-45
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] The Risk of Exacerbation for Asthma from Questionnaire Survey in Japanese Population.2017
Author(s)
H. Ueno, T. Koya, K. Yoshizawa, A. Aoki, Y. Kimura, H. Takeuchi, M. Hayashi, T. Sakagami, T. Kikuchi, T. Hasegawa, E. Suzuki.
Organizer
2017 American Thoracic Society International Conference
Related Report
Int'l Joint Research
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[Presentation] Comparison Between Ventilator-Associated Events and Conventional Ventilator Associated Pneumonia Surveillance in Japan.2017
Author(s)
M. Sato, Y. Tanabe, M. Uchiyama, A. Sakagami, C. Tsubata, H. Cho, N. Aoki, H. Moro, H. Endoh, T. Kikuchi, A. Saitoh.
Organizer
2017 American Thoracic Society International Conference
Related Report
Int'l Joint Research
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[Presentation] Involvement of Extracellular ATP in Mucus Production During Rhinovirus Infection.2017
Author(s)
H. Aizawa, A. Koarai, Y. Shishikura, M. Yamaya, H. Sugiura, M. Watanabe, Y. Hashimoto, T. Numakura, T. Makiguchi, K. Abe, M. Yamada, T. Kikuchi, Y. Hoshikawa, Y. Okada, M. Ichinose.
Organizer
2017 American Thoracic Society International Conference
Related Report
Int'l Joint Research
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[Presentation] インフルエンザ感染2016
Author(s)
菊地利明
Organizer
第31回日本糖尿病合併症学会
Place of Presentation
仙台国際センター、仙台市、宮城県
Year and Date
2016-10-07
Related Report
Invited
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[Presentation] 非結核性抗酸菌症2016
Author(s)
菊地利明
Organizer
第56回日本呼吸器学会学術講演会
Place of Presentation
国立京都国際会館、京都市、京都府
Year and Date
2016-04-08
Related Report
Invited
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