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Production of human induced bronchiolar progenitors

Research Project

Project/Area Number 15K15316
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Respiratory organ internal medicine
Research InstitutionNiigata University

Principal Investigator

KIKUCHI Toshiaki  新潟大学, 医歯学系, 教授 (10280926)

Co-Investigator(Renkei-kenkyūsha) KANEHIRA Masahiko  東北大学, 大学病院, 助教 (90374941)
Research Collaborator SUZUKI Takuji  自治医科大学, 医学部, 准教授 (80344670)
GOMI Kazunori  コーネル大学 (20400335)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords前駆細胞
Outline of Final Research Achievements

The aim of this study is to establish the method of preparing mouse induced bronchiolar progenitor cells (referred to in the text as “iBP cells”), which will be applied to that of preparing human iBP cells. The achievement of this study is expected not only to provide mechanistic insights into the cell dedifferentiation specific to respiratory tract epithelial cells, but also to contribute to development of innovative medical technology by offering biomaterial indispensable for regenerative medicine. This grant support for 3 years enabled us to elucidate the characteristic feature of iBP cells and the molecular mechanism controlling the dedifferentiation step toward iBP cells.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report

Research Products

(56 results)

All 2018 2017 2016 2015 Other

All Journal Article Presentation Book Remarks Patent(Industrial Property Rights)

  • [Journal Article] Peripheral alveolar nitric oxide concentration reflects alveolar inflammation in autoimmune pulmonary alveolar proteinosis.2018

    • Author(s)
      Hirano T, Ohkouchi S, Tode N, Kobayashi M, Ono M, Satoh T, Mitsuishi Y, Watanabe A, Tabata M, Irokawa T, Ogawa H, Sugiura H, Kikuchi T, Akasaka K, Tazawa R, Inoue Y, Nakata K, Kurosawa H, Ichinose M.
    • Journal Title

      ERJ Open Research.

      Volume: 4 Pages: 00071-2017

    • DOI
      10.1183/23120541.00071-2017
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] In vitro activity of various antibiotics against clinical strains of Legionella species isolated in Japan.2018

    • Author(s)
      Miyashita N, Kobayashi I, Higa F, Aoki Y, Kikuchi T, Seki M, Tateda K, Maki N, Uchino K, Ogasawara K, Kurachi S, Ishikawa T, Ishimura Y, Kanesaka I, Kiyota H, Watanabe A.
    • Journal Title

      J Infect Chemother.

      Volume: 24 Pages: 325-329

    • DOI
      10.1016/j.jiac.2018.01.018
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Clinical significance of interferon-γ neutralizing autoantibodies against disseminated nontuberculous mycobacterial disease.2018

    • Author(s)
      Aoki A, Sakagami T, Yoshizawa K, Shima K, Toyama M, Tanabe Y, Moro H, Aoki N, Watanabe S, Koya T, Hasegawa T, Morimoto K, Kurashima A, Hoshino Y, Trapnell BC, Kikuchi T.
    • Journal Title

      Clin Infect Dis.

      Volume: 66 Pages: 1239-1245

    • DOI
      10.1093/cid/cix996
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Endobronchial topical amphotericin B instillation for pulmonary chromomycosis after lung transplantation: A case report.2018

    • Author(s)
      Mitomo H, Sakurada A, Matsuda Y, Notsuda H, Watanabe T, Oishi H, Niikawa H, Maeda S, Noda M, Sado T, Amemiya T, Yoshida Y, Kikuchi T, Kamei K, Okada Y.
    • Journal Title

      Transplant Proc.

      Volume: 50 Pages: 939-942

    • DOI
      10.1016/j.transproceed.2017.12.028
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A Cluster Analysis of Bronchial Asthma Patients with Depressive Symptoms2018

    • Author(s)
      Seino Y, Hasegawa T, Koya T, Sakagami T, Mashima I, Shimizu N, Muramatsu Y, Muramatsu K, Suzuki E, Kikuchi T.
    • Journal Title

      Intern. Med.

      Volume: 印刷中 Issue: 14 Pages: 1967-1975

    • DOI
      10.2169/internalmedicine.9073-17
    • NAID
      130006464153
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Clinical and genetic implications of mutation burden in squamous cell carcinoma of the lung.2018

    • Author(s)
      Okamoto Tatsuro、Takada Kazuki、Sato Seijiro、Toyokawa Gouji、Tagawa Tetsuzo、Shoji Fumihiro、Nakanishi Ryota、Oki Eiji、Koike Terumoto、Nagahashi Masayuki、Ichikawa Hiroshi、Shimada Yoshifumi、Watanabe Satoshi、Kikuchi Toshiaki、Akazawa Kouhei、Lyle Stephen、Takabe Kazuaki、Okuda Shujiro、Sugio Kenji
    • Journal Title

      Ann Surg Oncol.

      Volume: 25 Pages: 1564-1571

    • DOI
      10.1245/s10434-018-6401-1
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Natural course and potential prognostic factors for sleep-disordered breathing in multiple system atrophy.2017

    • Author(s)
      Ohshima Y, Nakayama H, Matsuyama N, Hokari S, Sakagami T, Sato T, Koya T, Takahashi T, Kikuchi T, Nishizawa M, Shimohata T
    • Journal Title

      Sleep Med.

      Volume: 34 Pages: 13-17

    • DOI
      10.1016/j.sleep.2017.01.020
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Megalin blockade with cilastatin suppresses drug-induced nephrotoxicity.2017

    • Author(s)
      Hori Y, Aoki N, Kuwahara S, Hosojima M, Kaseda R, Goto S, Iida T, De S, Kabasawa H, Kaneko R, Aoki H, Tanabe Y, Kagamu H, Narita I, Kikuchi T, Saito A
    • Journal Title

      J Am Soc Nephrol.

      Volume: 未定 Pages: 1783-1791

    • DOI
      10.1681/asn.2016060606
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Exome sequencing deciphers a germline MET mutation in familial epidermal growth factor receptor-mutant lung cancer2017

    • Author(s)
      Tode N, Kikuchi T, Sakakibara T, Hirano T, Inoue A, Ohkouchi S, Tamada T, Okazaki T, Koarai A, Sugiura H, Niihori T, Aoki Y, Nakayama K, Matsumoto K, Matsubara Y, Yamamoto M, Watanabe A, Nukiwa T, Ichinose M.
    • Journal Title

      Cancer Science

      Volume: 印刷中 Pages: 1263-1270

    • DOI
      10.1111/cas.13233
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] A-DROP system for prognostication of NHCAP inpatients.2017

    • Author(s)
      Koizumi T, Tsukada H, Ito K, Shibata S, Hokari S, Tetsuka T, Aoki N, Moro H, Tanabe Y, Kikuchi T
    • Journal Title

      J Infect Chemother.

      Volume: 23 Pages: 523-530

    • DOI
      10.1016/j.jiac.2017.04.013
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Transfer of in vitro-expanded naïve T cells after lymphodepletion enhances antitumor immunity through the induction of polyclonal antitumor effector T cells.2017

    • Author(s)
      Tanaka Tomohiro、Watanabe Satoshi、Takahashi Miho、Sato Ko、Saida Yu、Baba Junko、Arita Masashi、Sato Miyuki、Ohtsubo Aya、Shoji Satoshi、Nozaki Koichiro、Ichikawa Kosuke、Kondo Rie、Aoki Nobumasa、Ohshima Yasuyoshi、Sakagami Takuro、Abe Tetsuya、Moro Hiroshi、Koya Toshiyuki、Tanaka Junta
    • Journal Title

      PLoS One.

      Volume: 12

    • DOI
      10.1371/journal.pone.0183976
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Phenotypic analysis of asthma in Japanese athletes2017

    • Author(s)
      Tsukioka K, Koya T, Ueno H, Hayashi M, Sakagami T, Hasegawa T, Arakawa M, Suzuki E, Kikuchi T.
    • Journal Title

      Allergol. Int.

      Volume: 66 Issue: 4 Pages: 550-556

    • DOI
      10.1016/j.alit.2017.02.009
    • NAID
      130006179506
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Clinical presentation of Legionella pneumonia: Evaluation of clinical scoring systems and therapeutic efficacy.2017

    • Author(s)
      Miyashita N, Higa F, Aoki Y, Kikuchi T, Seki M, Tateda K, Maki N, Uchino K, Ogasawara K, Kiyota H, Watanabe A.
    • Journal Title

      J Infect Chemother.

      Volume: 23 Pages: 727-732

    • DOI
      10.1016/j.jiac.2017.09.001
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effect of lymphodepletion on donor T cells and the role of recipient cells persisting after cytotoxic treatments in cancer Immunotherapies.2017

    • Author(s)
      Watanabe Satoshi、Arita Masashi、Takahashi Miho、Saida Yu、Koya Toshiyuki、Kikuchi Toshiaki
    • Journal Title

      Crit Rev Immunol.

      Volume: 37 Pages: 59-73

    • DOI
      10.1615/critrevimmunol.2018019497
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Cytokine profiles of amyopathic dermatomyositis with interstitial lung diseases treated with mycophenolate.2017

    • Author(s)
      Masachika Hayashi, Ami Aoki, Katsuaki Asakawa, Takuro Sakagami, Toshiaki Kikuchi, and Toshinori Takada
    • Journal Title

      Respirol Case Rep

      Volume: 5 Pages: 1-4

    • DOI
      10.1002/rcr2.235
    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Effects of sublingual immunotherapy in a murine asthma model sensitized by intranasal administration of house dust mite extracts2017

    • Author(s)
      Shima K, Koya T, Tsukioka K, Sakagami T, Hasegawa T, Fukano C, Ohashi-Doi K, Watanabe S, Suzuki E, Kikuchi T.
    • Journal Title

      Allergol. Int.

      Volume: 66 Issue: 1 Pages: 89-96

    • DOI
      10.1016/j.alit.2016.05.012
    • NAID
      130005308448
    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Mycophenolate mofetil for the patients with interstitial lung diseases in amyopathic dermatomyositis with anti-MDA-5 antibodies.2017

    • Author(s)
      Masachika Hayashia, Toshiaki Kikuchia, and Toshinori Takada
    • Journal Title

      Clin Rheumatol

      Volume: 36 Pages: 239-240

    • DOI
      10.1007/s10067-016-3443-2
    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Two cases of pseudo-achalasia with lung cancer: a case report and short literature review.2016

    • Author(s)
      Hirano T, Miyauchi E, Inoue A, Igusa R, Chiba S, Sakamoto K, Sugiura H, Kikuchi T, Ichinose M.
    • Journal Title

      Respir Investig

      Volume: 54 Pages: 494-499

    • DOI
      10.1016/j.resinv.2016.04.006
    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Extracellular ATP is involved in dsRNA-induced MUC5AC production via P2Y2R in human airway epithelium.2016

    • Author(s)
      Shishikura Y, Koarai A, Aizawa H, Yamaya M, Sugiura H, Watanabe M, Hashimoto Y, Numakura T, Makiguti T, Abe K, Yamada M, Kikuchi T, Hoshikawa Y, Okada Y, Ichinose M.
    • Journal Title

      Respir Res

      Volume: 17 Pages: 121-121

    • DOI
      10.1186/s12931-016-0438-0
    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] OX40 ligand newly expressed on bronchiolar progenitors mediates infection and further exacerbates pneumoria.2016

    • Author(s)
      Hirano T, Kikuchi T, Tode N, Santoso A, Yamada M, Mitsuhashi Y, Komatsu R, Kawabe T, Tanimoto T, Ishii N, Tanaka Y, Nishimura H, Nukiwa T, Watanabe A, Ichinose M.
    • Journal Title

      EMBO Mol Med

      Volume: 8 Pages: 422-436

    • DOI
      10.15252/emmm.201506154
    • Related Report
      2016 Research-status Report 2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Syndecan 4 mediates Nrf2-dependent expansion of bronchiolar progenitors that protect against lung inflammation.2016

    • Author(s)
      Santoso A, Kikuchi T, Tode N, Hirano T, Komatsu R, Damayanti T, Motohashi H, Yamamoto M, Kojima T, Uede T, Nukiwa T, Ichinose M
    • Journal Title

      Mol Ther

      Volume: 24 Pages: 41-52

    • DOI
      10.1038/mt.2015.153
    • Related Report
      2016 Research-status Report 2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] 27-Hydroxycholesterol accelerates cellular senescence in human lung resident cells.2016

    • Author(s)
      Hashimoto Y, Sugiura H, Togo S, Koarai A, Abe K, Yamada M, Ichikawa T, Kikuchi T, Numakura T, Onodera K, Tanaka R, Sato K, Yanagisawa S, Okazaki T, Tamada T, Kikuchi T, Hoshikawa Y, Okada Y, Ichinose M.
    • Journal Title

      Am J Physiol Lung Cell Mol Physiol.

      Volume: 310

    • DOI
      10.1152/ajplung.00351.2015
    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Possible role of Kruppel-like factor 5 in the remodeling of small airways and pulmonary vessels in chronic obstructive pulmonary disease.2016

    • Author(s)
      Abe. K., H. Sugiura, Y. Hashimoto, T. Ichikawa, A. Koarai, M. Yamada, T. Numakura, K. Onodera, R. Tanaka, K. Sato, S. Yanagisawa, T. Okazaki, T. Tamada, T. Kikuchi and M. Ichinose.
    • Journal Title

      Respir Res.

      Volume: 17 Pages: 7-7

    • DOI
      10.1186/s12931-016-0322-y
    • Related Report
      2016 Research-status Report 2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Two cases of endobronchial aspergilloma complicated with primary and metastatic lung cancer: A case report and literature review.2016

    • Author(s)
      Hirano T, Yamada M, Igusa R, Tanno A, Numakura T, Sakamoto K, Kikuchi T, Ichinose M.
    • Journal Title

      Respir Investig

      Volume: 54

    • DOI
      10.1016/j.resinv.2015.12.005
    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Simultaneous development of sarcoidosis and cutaneous vasculitis in a patient with refractory Crohn’s disease during infliximab therapy.2016

    • Author(s)
      Numakura T, Tamada T, Nara M, Muramatsu S, Murakami K, Kikuchi T, Kobayashi M, Muroi M, Okazaki T, Takagi S, Eishi Y, Ichinose M.
    • Journal Title

      BMC Pulm Med

      Volume: 16 Pages: 30-30

    • DOI
      10.1186/s12890-016-0193-5
    • Related Report
      2016 Research-status Report 2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Chronic inflammation, lymphangiogenesis, and effect of an anti-VEGFR therapy in a mouse model and in human patients with aspiration pneumonia2015

    • Author(s)
      Nihei M, Okazaki T, Ebihara S, Kobayashi M, Niu K, Gui P, Tamai T, Nukiwa T, Yamaya M, Kikuchi T, Nagatomi R, Ebihara T, Ichinose M.
    • Journal Title

      J Pathology

      Volume: ;235 Pages: 632-45

    • DOI
      10.1002/path.4473
    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] 肺MAC症の病態と菌側因子2017

    • Author(s)
      菊地利明
    • Organizer
      第92回日本結核病学会総会
    • Place of Presentation
      東京国際フォーラム、千代田区、東京都
    • Year and Date
      2017-03-23
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] ゲノム医学からみた肺感染症2017

    • Author(s)
      菊地利明
    • Organizer
      第57回日本呼吸器学会学術講演会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Autoimmune Nontuberculous Mycobacterial Disease:Characteristic Phenotypes of Cases with Anti-Interferon-g Neutralizing Autoantibodies.2017

    • Author(s)
      A. Aoki, T. Sakagami, K. Yoshizawa, K. Shima, N. Aoki, H. Moro, Y. Tanabe, T. Koya, T. Hasegawa, T. Kikuchi.
    • Organizer
      2017 American Thoracic Society International Conference
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The Risk of Exacerbation for Asthma from Questionnaire Survey in Japanese Population.2017

    • Author(s)
      H. Ueno, T. Koya, K. Yoshizawa, A. Aoki, Y. Kimura, H. Takeuchi, M. Hayashi, T. Sakagami, T. Kikuchi, T. Hasegawa, E. Suzuki.
    • Organizer
      2017 American Thoracic Society International Conference
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Comparison Between Ventilator-Associated Events and Conventional Ventilator Associated Pneumonia Surveillance in Japan.2017

    • Author(s)
      M. Sato, Y. Tanabe, M. Uchiyama, A. Sakagami, C. Tsubata, H. Cho, N. Aoki, H. Moro, H. Endoh, T. Kikuchi, A. Saitoh.
    • Organizer
      2017 American Thoracic Society International Conference
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Establishment of a Web-Based Inquiry System for Elemental Analysis of Lung Tissue of Occupational Lung Diseases.2017

    • Author(s)
      H. Moriyama, M. Kobayashi, A. Aoki, K. Asakawa, T. Sakagami, T. Koya, T. Ohdaira, T. Takada, T. Kikuchi.
    • Organizer
      2017 American Thoracic Society International Conference
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Anti-BPIFB1 Autoantibodies Were Identified in Three Cases with Idiopathic Interstitial Lung Disease.2017

    • Author(s)
      K. Yoshizawa, T. Sakagami, A. Aoki, K. Asakawa, T. Koya, T. Takada, T. Kikuchi.
    • Organizer
      2017 American Thoracic Society International Conference
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Involvement of Extracellular ATP in Mucus Production During Rhinovirus Infection.2017

    • Author(s)
      H. Aizawa, A. Koarai, Y. Shishikura, M. Yamaya, H. Sugiura, M. Watanabe, Y. Hashimoto, T. Numakura, T. Makiguchi, K. Abe, M. Yamada, T. Kikuchi, Y. Hoshikawa, Y. Okada, M. Ichinose.
    • Organizer
      2017 American Thoracic Society International Conference
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Mycophenolate Mofetil for Japanese Patients with Interstitial Lung Diseases in Amyopathic Dermatomyositis with Anti-MDA-5 Antibody.2017

    • Author(s)
      T. Takada, K. Asakawa, A. Aoki, M. Hayashi, T. Sakagami, T. Kikuchi.
    • Organizer
      2017 American Thoracic Society International Conference
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 気道上皮前駆細胞による抗炎症応答2017

    • Author(s)
      菊地利明
    • Organizer
      第48回ヒューマンサイエンス総合研究セミナー
    • Place of Presentation
      砂防会館別館、千代田区、東京都
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] 呼吸器感染症を斬る─新世代に託される課題─2016

    • Author(s)
      菊地利明
    • Organizer
      第65回日本感染症学会東日本地方会学術集会 第63回日本化学療法学会東日本支部総会 合同学会
    • Place of Presentation
      朱鷺メッセ、新潟市、新潟県
    • Year and Date
      2016-10-26
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] インフルエンザ感染2016

    • Author(s)
      菊地利明
    • Organizer
      第31回日本糖尿病合併症学会
    • Place of Presentation
      仙台国際センター、仙台市、宮城県
    • Year and Date
      2016-10-07
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] The pulmonary OX40 ligand expression induced by the influenza infection plays a potential role in the pathogenesis.2016

    • Author(s)
      T. Hirano, T. Kikuchi, N. Tode, H. Sugiura, M. Ichinose,
    • Organizer
      American Thoracic Society International Conference
    • Place of Presentation
      Moscone Center, San Francisco, CA, USA
    • Year and Date
      2016-05-13
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 抗酸菌感染症の現状と将来展望2016

    • Author(s)
      菊地利明
    • Organizer
      第90回日本感染症学会総会・学術講演会
    • Place of Presentation
      仙台国際センター、仙台市、宮城県
    • Year and Date
      2016-04-15
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] 非結核性抗酸菌症2016

    • Author(s)
      菊地利明
    • Organizer
      第56回日本呼吸器学会学術講演会
    • Place of Presentation
      国立京都国際会館、京都市、京都府
    • Year and Date
      2016-04-08
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] Bronchial progenitor cells function as antigen presenting cells.2015

    • Author(s)
      T Hirano, T Kikuchi, T Tode, M Ichinose.
    • Organizer
      American Thoracic Society International Conference
    • Place of Presentation
      Denver(米国)
    • Year and Date
      2015-05-15
    • Related Report
      2015 Research-status Report
  • [Presentation] Whole-exome sequencing of familial non-small cell lung cancer patients with the EGFR gene mutations.2015

    • Author(s)
      .N. Tode, T Kikuchi, T Hirano, A Santoso, M Ichinose.
    • Organizer
      American Thoracic Society International Conference
    • Place of Presentation
      Denver(米国)
    • Year and Date
      2015-05-15
    • Related Report
      2015 Research-status Report
  • [Presentation] シンデカン4による細気管支前駆細胞への脱分化機構を介した肺炎症に対する新規治療法2015

    • Author(s)
      小松理世、菊地利明、アリフ サントソ、平野泰三、東出直樹、一ノ瀬正和
    • Organizer
      第55回日本呼吸器学会学術講演会
    • Place of Presentation
      東京国際フォーラム(東京都・千代田区)
    • Year and Date
      2015-04-17
    • Related Report
      2015 Research-status Report
  • [Presentation] 気道上皮前駆細胞はインフルエンザウイルスの細胞感受性が最も高い2015

    • Author(s)
      平野泰三、菊地利明、東出直樹、一ノ瀬正和
    • Organizer
      第55回日本呼吸器学会学術講演会
    • Place of Presentation
      東京国際フォーラム(東京都・千代田区)
    • Year and Date
      2015-04-17
    • Related Report
      2015 Research-status Report
  • [Presentation] EGFR遺伝子変異を伴う家族性肺腺癌患者における遺伝学的機序の解明2015

    • Author(s)
      東出直樹, 菊地利明, 平野泰三, Arif Santoso, 一ノ瀬正和,
    • Organizer
      第55回日本呼吸器学会学術講演会
    • Place of Presentation
      東京国際フォーラム(東京都・千代田区)
    • Year and Date
      2015-04-17
    • Related Report
      2015 Research-status Report
  • [Book] Lung Disease Associated with Rheumatioid Arthritis.2018

    • Author(s)
      Moro H, Kikuchi T.
    • Total Pages
      199
    • Publisher
      Springer Nature Singapore Pte
    • Related Report
      2017 Annual Research Report
  • [Book] 診療ガイドライン UP-TO-DATE 2018-20192017

    • Author(s)
      茂呂寛、菊地利明
    • Total Pages
      1037
    • Publisher
      メディカルレビュー社
    • Related Report
      2017 Annual Research Report
  • [Book] 抗菌薬パーフェクトガイド2016

    • Author(s)
      菊地利明
    • Total Pages
      359
    • Publisher
      ヴァン メディカル
    • Related Report
      2016 Research-status Report
  • [Book] 咳の診かた、止めかた2016

    • Author(s)
      黒川允、菊地利明
    • Total Pages
      246
    • Publisher
      羊土社
    • Related Report
      2016 Research-status Report
  • [Book] 診療ガイドライン UP-TO-DATE 2016-20172016

    • Author(s)
      菊地利明
    • Total Pages
      942
    • Publisher
      メディカルレビュー社
    • Related Report
      2015 Research-status Report
  • [Book] 最新透析医療 先端技術との融合2016

    • Author(s)
      三浦理、各務博、風間順一郎、成田一衛、菊地利明
    • Total Pages
      859
    • Publisher
      医薬ジャーナル社
    • Related Report
      2015 Research-status Report
  • [Remarks] 新潟大学大学院医歯学総合研究科 呼吸器・感染症内科学分野

    • URL
      http://www.med.niigata-u.ac.jp/resp/welcome.html
    • Related Report
      2017 Annual Research Report
  • [Remarks] 新潟大学大学院医歯学総合研究科呼吸器・感染症内科学分野

    • URL
      http://www.med.niigata-u.ac.jp/resp/welcome.html
    • Related Report
      2016 Research-status Report
  • [Remarks] 新潟大学大学院医歯学総合研究科 呼吸器・感染症内科学分野

    • URL
      http://www.med.niigata-u.ac.jp/resp/welcome.html
    • Related Report
      2015 Research-status Report
  • [Patent(Industrial Property Rights)] 抗ヒトOX40リガンド抗体を用いたインフルエンザの新規治療法2015

    • Inventor(s)
      菊地利明、平野泰三、一ノ瀬正和、石井直人、田中勇悦
    • Industrial Property Rights Holder
      菊地利明、平野泰三、一ノ瀬正和、石井直人、田中勇悦
    • Industrial Property Rights Type
      特許
    • Filing Date
      2015-06-30
    • Application Year
      2015
    • Related Report
      2015 Research-status Report
    • Overseas

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Published: 2015-04-16   Modified: 2019-03-29  

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