| Project/Area Number |
15K15321
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Niigata University |
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Principal Investigator |
NAKATA Koh 新潟大学, 医歯学総合病院, 教授 (80207802)
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| Co-Investigator(Kenkyū-buntansha) |
田澤 立之 新潟大学, 医歯学総合病院, 准教授 (70301041)
北村 信隆 新潟大学, 医歯学総合病院, 特任教授 (90224972)
井上 義一 独立行政法人国立病院機構(近畿中央胸部疾患センター臨床研究センター), 臨床研究センター, 臨床研究センター長 (90240895)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 自己免疫性肺胞蛋白症 / 抗GM-CSF自己抗体 / 内因性GM-CSF / 免疫複合体 / 全肺洗浄法 / 肺胞蛋白症 / 分子細胞呼吸器学 |
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| Outline of Final Research Achievements |
During whole lung lavage, the concentration of GM-CSF autoantibody in the lavage fluid decreased serially to 0.1% of the first lavage fluid, whereas GM-CSF production by alveolar type II cells remained and form immune complex with GM-CSF autoantibody entered into the alveoli from the blood. The complex may be gradually absorbed by macrophages. These reactions can be expressed as a mathematical equations. Here, we noticed that the initial conditions such as GM-CSF production level and number of GM-CSF autoantibody molecules affect the simulation by the equations.
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