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Large molecular complex of cell surface in malignant pleural mesotheliom as a novel treatment target

Research Project

Project/Area Number 15K15324
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Respiratory organ internal medicine
Research InstitutionJuntendo University

Principal Investigator

OHNUMA Kei  順天堂大学, 医学(系)研究科(研究院), 准教授 (10396872)

Co-Investigator(Kenkyū-buntansha) 岩田 哲史  順天堂大学, 医学(系)研究科(研究院), 非常勤講師 (00396871)
岩尾 憲明  順天堂大学, 医学部, 准教授 (00309139)
Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords悪性中皮腫 / CD26 / ソマトスタチン受容体 / ペリオスチン / CD26抗体療法 / dipeptydil peptidase 4 / ソマトスタチン
Outline of Final Research Achievements

Malignant pleural mesothelioma (MPM) is a rare and aggressive neoplasm deriving from the pleural mesothelial lining. Despite the modest clinical benefit of a multimodality treatment approach including surgery, combination chemotherapy and radiation, prognosis remains grim with poor overall survival. New approaches based on deregulated pathways and targeted therapies are required to improve survival of MPM patients. We have had a long-standing interest in the role of CD26 in cancer biology and its suitability as a novel therapeutic target in selected neoplasms. Our previous work demonstrated that CD26 is preferentially expressed in MPM cells but not in normal mesothelial cells. Recently, we reported robust in vivo data on the anti-tumor activity of anti-CD26 monoclonal antibody in mouse xenograft models. We herein showed significant novel findings and the early clinical development of a CD26-targeted therapy for MPM, advances that can lead to a more hopeful future for MPM patients.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • Research Products

    (14 results)

All 2017 2016 2015 Other

All Int'l Joint Research (2 results) Journal Article (11 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 10 results,  Open Access: 6 results,  Acknowledgement Compliant: 6 results) Book (1 results)

  • [Int'l Joint Research] フロリダ大学/ヴァンダービルト大学(米国)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] フロリダ大学(米国)

    • Related Report
      2015 Research-status Report
  • [Journal Article] First-in-human phase 1 of YS110, a monoclonal antibody directed against CD26 in advanced CD26-expressing cancers2017

    • Author(s)
      Angevin, E. Isambert, N. Trillet-Lenoir, V. You, B. Alexandre, J. Zalcman, G. Vielh, P. Farace, F. Valleix, F. Podoll, T. Kuramochi, Y. Miyashita, I. Hosono, O. Dang, N. H. Ohnuma, K. Yamada, T. Kaneko, Y. Morimoto, C.
    • Journal Title

      Br J Cancer

      Volume: 印刷中 Issue: 9 Pages: 1-9

    • DOI

      10.1038/bjc.2017.62

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A possible role for CD26/DPPIV enzyme activity in the regulation of psoriatic pruritus2017

    • Author(s)
      Komiya, E. Hatano, R. Otsuka, H. Itoh, T. Yamazaki, H. Yamada, T. Dang, N. H. Tominaga, M. Suga, Y. Kimura, U. Takamori, K. Morimoto, C. Ohnuma, K.
    • Journal Title

      J Dermatol Sci

      Volume: 印刷中 Issue: 3 Pages: 212-221

    • DOI

      10.1016/j.jdermsci.2017.03.005

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Development of New Therapy for Malignant Mesothelioma Based on CD26 Molecule2016

    • Author(s)
      Morimoto, C. Ohnuma, K.
    • Journal Title

      Gan To Kagaku Ryoho

      Volume: 43 Pages: 855-62

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Inhibition of VEGF-dependent angiogenesis by the anti-CD82 monoclonal antibody 4F9 through regulation of lipid raft microdomains2016

    • Author(s)
      Nomura, S. Iwata, S. Hatano, R. Komiya, E. Dang, N. H. Iwao, N. Ohnuma, K. Morimoto, C.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 474 Issue: 1 Pages: 111-7

    • DOI

      10.1016/j.bbrc.2016.04.081

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Role of IL-26+CD26+CD4 T Cells in Pulmonary Chronic Graft-Versus-Host Disease and Treatment with Caveolin-1-Ig Fc Conjugate2016

    • Author(s)
      Ohnuma, K. Hatano, R. Itoh, T. Iwao, N. Dang, N. H. Morimoto, C.
    • Journal Title

      Crit Rev Immunol

      Volume: 36 Issue: 3 Pages: 239-267

    • DOI

      10.1615/critrevimmunol.2016018772

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Remission of remitting seronegative symmetrical synovitis with pitting edema after unrelated cord blood transplantation for myelodysplastic syndrome.2015

    • Author(s)
      Ishii H, Konuma T, Ohnuma K, Hosono O, Tanaka H, Kato S, Tojo A, Takahashi S.
    • Journal Title

      Ann Hematol.

      Volume: 95 Issue: 3 Pages: 523-524

    • DOI

      10.1007/s00277-015-2555-0

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CD26-mediated induction of EGR2 and IL-10 as potential regulatory mechanism for CD26 costimulatory pathway.2015

    • Author(s)
      Hatano R, Ohnuma K, Otsuka H, Komiya E, Taki I, Iwata S, Dang NH, Okumura K, Morimoto C.
    • Journal Title

      J Immunol.

      Volume: Vol 194 Issue: 3 Pages: 960-72

    • DOI

      10.4049/jimmunol.1402143

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Deep venous thrombosis was not detected after total knee arthroplasty in Japanese patients with haemophilia.2015

    • Author(s)
      Takedani H, Ohnuma K, Hirose J.
    • Journal Title

      Haemophilia

      Volume: 21 Issue: 5 Pages: 585-588

    • DOI

      10.1111/hae.12643

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Regulation of Pulmonary Graft-versus-Host Disease by IL-26+CD26+CD4 T Lymphocytes.2015

    • Author(s)
      Ohnuma K, Hatano R, Aune TM, Otsuka H, Iwata S, Dang NH, Yamada T, Morimoto C.
    • Journal Title

      J Immunol

      Volume: 194(8) Issue: 8 Pages: 3697-712

    • DOI

      10.4049/jimmunol.1402785

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Modulation of immunological responses and amelioration of collagen-induced arthritis by the novel roxithromycin derivative 5-I.2015

    • Author(s)
      Otsuki N, Iwata S, Yamada T, Hosono O, Dang NH, Hatano R, Ohnuma K, Morimoto C.
    • Journal Title

      Modern Rheumatology

      Volume: 25 Pages: 562-570

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] The Role of Cas-L/NEDD9 as a Regulator of Collagen-induced Arthritis in a Murine Model2015

    • Author(s)
      Tomoki Katayose, Satoshi Iwata, Naoki Oyaizu, Osamu Hosono, Taketo Yamada, Nam H Dang, Ryo Hatano, Hirotoshi Tanaka, Kei Ohnuma, Chikao Morimoto
    • Journal Title

      Biochem Bilphys Res Commun

      Volume: 印刷中 Issue: 4 Pages: 1069-75

    • DOI

      10.1016/j.bbrc.2015.03.156

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Book] Horizons in Cancer Research2017

    • Author(s)
      Ohnuma, K. Hatano, R. Yamazaki, H. Kaneko, Y. Dang, N. H. Morimoto, C.
    • Total Pages
      212
    • Publisher
      Nova Science Publishers, Inc.
    • Related Report
      2016 Annual Research Report

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Published: 2015-04-16   Modified: 2022-02-16  

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