| Project/Area Number |
15K15325
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | National Institute of Infectious Diseases |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 衛生仮説 / RSV / アレルギー / Th1/Th2 |
|---|
| Outline of Final Research Achievements |
The hygiene hypothesis is a hypothesis that states a lack of early childhood exposure to infectious agents increases susceptibility to allergic diseases by suppressing the development of Th1-based immunity. In this study, we investigated whether respiratory syncytial virus (RSV) infection in infancy affects allergic responses in adult mice. As a result, mice that infected with RSV at a week old significantly increased susceptibility to house dust mite-induced allergic responses at 8 weeks old. These results suggest that RSV infection in infancy leads to enhanced susceptibility to allergic diseases.
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