Reconstitution of renal vasculature based on its development

Research Project

Project/Area Number	15K15332
Research Category	Grant-in-Aid for Challenging Exploratory Research
Allocation Type	Multi-year Fund
Research Field	Kidney internal medicine
Research Institution	Kumamoto University
Principal Investigator	NISHINAKAMURA Ryuichi 熊本大学, 発生医学研究所, 教授 (70291309)
Project Period (FY)	2015-04-01 – 2017-03-31
Project Status	Completed (Fiscal Year 2016)
Budget Amount *help	¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000) Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000) Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords	腎臓発生 / 血管発生 / 血管内皮
Outline of Final Research Achievements	While we previously succeeded in inducing kidney tissues from stem cells, integration of vasculature is necessary for the renal functions.The purpose of this project is to understand the origin and developmental processes of renal vasculature and apply the knowledge to the vascular reconstitution. We first described the development of extra- and intra-renal arteries/veins. We then identified the molecular profiles of renal vasculature. We also transplanted the embryonic mouse kidneys to the host animals to analyze the development of the vasculature.