| Project/Area Number |
15K15335
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurology
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| Research Institution | Niigata University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
KASUGA Kensaku 新潟大学, 脳研究所, 助教 (70547546)
TOKUTAKE Takayoshi 新潟大学, 医歯学総合病院, 助教 (00707838)
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|---|
| Research Collaborator |
KAWAI Nobuhiro 味の素株式会社, 研究員
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| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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|---|
| Keywords | アミノ酸 / 認知症 |
|---|
| Outline of Final Research Achievements |
There is a strong need for blood-based biomarker for the diagnosis of dementia including Alzheimer’s disease (AD). Plasma free amino acids and amines are potent metabolites, and different patterns of plasma free amino acid have shown to be associated with various disease conditions in previous studies. We here determine the plasma free amino acids in patients with AD (n=36) and cognitively normal controls (n=34). Five metabolites showed significant changes in AD patients. Among them, the level of the amino acid was significantly correlated with the MMSE scores. These results suggest that measurement of the plasma free amino acids and amines may offer a potential blood-based diagnostic tool for AD.
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