Amino acid profile in plasma of Alzheimer's disease
Project/Area Number |
15K15335
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Neurology
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Research Institution | Niigata University |
Principal Investigator |
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Co-Investigator(Renkei-kenkyūsha) |
KASUGA Kensaku 新潟大学, 脳研究所, 助教 (70547546)
TOKUTAKE Takayoshi 新潟大学, 医歯学総合病院, 助教 (00707838)
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Research Collaborator |
KAWAI Nobuhiro 味の素株式会社, 研究員
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
Keywords | アミノ酸 / 認知症 |
Outline of Final Research Achievements |
There is a strong need for blood-based biomarker for the diagnosis of dementia including Alzheimer’s disease (AD). Plasma free amino acids and amines are potent metabolites, and different patterns of plasma free amino acid have shown to be associated with various disease conditions in previous studies. We here determine the plasma free amino acids in patients with AD (n=36) and cognitively normal controls (n=34). Five metabolites showed significant changes in AD patients. Among them, the level of the amino acid was significantly correlated with the MMSE scores. These results suggest that measurement of the plasma free amino acids and amines may offer a potential blood-based diagnostic tool for AD.
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Report
(4 results)
Research Products
(12 results)
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[Journal Article] Adult-onset leukoencephalopathy with axonal spheroids and pigmented glia associated with CSF1R mutation2017
Author(s)
Konno T, Yoshida K, Mizuno T, Kawarai T, Tada M, Nozaki H, Ikeda S, Nishizawa M, Onodera O, Wszolek ZK, Ikeuchi T
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Journal Title
European Journal of Neurology
Volume: 24
Issue: 1
Pages: 37-45
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Elevated C-reactive protein is associated with cognitive decline in outpatients of a general hospital: The Project in Sato for Total Health (PROST).2016
Author(s)
Watanabe Y, Kitamura K, Nakamura K, Sanpei K, Wakasugi M, Yokoseki A, Onodera O, Ikeuchi T, Kuwano R, Momotsu T, Narita I, Endo N
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Journal Title
Dementia Geriatric Cognitive Disorder EXTRA
Volume: 6
Issue: 1
Pages: 10-16
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Plasma desmosterol is associated with longitudinal cognitive decline in Alzheimer’s disease.2015
Author(s)
Sato Y, Bernier F, Yamanaka Y, Aoshima K, Oda Y, Ingelsson M, Lannfelt L, Miyashita A, Kuwano R, Ikeuchi T
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Journal Title
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring
Volume: 1
Issue: 1
Pages: 67-74
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] Age-weighted polygenic risk model effectively predicts the onset of Alzheimer disease.2017
Author(s)
Lee JJ, Kang S, Lee W, Gunasekaran TI, Park JE, Seo H, Park M, Rhee S, Kim H, Kim BC, Choo IH, Ikeuchi T, Choi KY, Lee KH
Organizer
Alzheimer's Association International Conference
Related Report
Int'l Joint Research
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